# US 8,569,449 B2 · Synthetic peptides and peptide mimetics

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- Number: US 8,569,449 B2
- Document ID: US8569449B2
- Status: Granted
- Kind: B2
- Application number: 12/599,021
- Filed: 2008-05-08
- Published: 2012-03-08
- Granted: 2013-10-29
- Earliest claimed: 2007-05-08
- Assignees: University of Louisville Research Foundation, Inc.
- Applicants: Sven-Ulrik Gorr
- Inventors: Sven-Ulrik Gorr
- Web page: https://patentgrep.com/patent/US8569449B2

## CPC

- C07K 7/08: having 12 to 20 amino acids (gastrins C07K14/595; somatostatins C07K14/655; melanotropins C07K14/68)
- A61P 5/00: Drugs for disorders of the endocrine system
- C07K 14/47: from mammals
- A61K 38/00: Medicinal preparations containing peptides (peptides containing beta-lactam rings A61K31/00; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, A61K31/00; ergot alkaloids of the cyclic peptide type A61K31/48; containing macromolecular compounds having statistically distributed amino acid units A61K31/74; medicinal preparations containing antigens or antibodies A61K39/00; medicinal preparations characterised by the non-active ingredients, e.g. peptides as drug carriers, A61K47/00)
- C07K: PEPTIDES (peptides in foodstuffs A23; obtaining protein compositions for foodstuffs, working-up proteins for foodstuffs A23J; preparations for medicinal purposes A61K; peptides containing beta-lactam rings C07D; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, C07D; ergot alkaloids of the cyclic peptide type C07D519/02; macromolecular compounds having statistically distributed amino acid units in their molecules, i.e. when the preparation does not provide for a specific; but for a random sequence of the amino acid units, homopolyamides and block copolyamides derived from amino acids C08G69/00; macromolecular products derived from proteins C08H1/00; preparation of glue or gelatine C09H; single cell proteins, enzymes C12N; genetic engineering processes for obtaining peptides C12N15/00; compositions for measuring or testing processes involving enzymes C12Q; investigation or analysis of biological material G01N33/00)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)

## Abstract

The present invention provides Parotid Secretory Protein peptides, nucleic acids encoding the peptides, and methods of using the peptides, and methods of screening GL13 mimetics.

## Claims

### Claim 1

An isolated and purified Parotid Secretory Protein (PSP) peptide of 13 to 50 amino acids in length comprising the amino acid sequence of SEQ ID NO: 8, SEQ ID NO: 11, SEQ ID NO: 12, or SEQ ID NO: 13.

### Claim 2 (depends on 1)

The isolated and purified Parotid Secretory Protein (PSP) peptide of claim 1, wherein the peptide is amidated at its C-terminal end.

### Claim 3 (depends on 1)

The PSP peptide of claim 1, wherein the peptide is between 13 and 20 amino acids in length.

### Claim 4 (depends on 1)

The PSP peptide of claim 1, wherein the peptide is between 13 and 15 amino acids in length.

### Claim 5 (depends on 1)

The PSP peptide of claim 1, wherein the peptide is 13 amino acids in length.

### Claim 6 (depends on 1)

The PSP peptide of claim 1, wherein the peptide is linear.