# US 8,569,448 B2 · NMDAR biomarkers for diagnosis and treatment of traumatic brain injury and other disorders

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- Number: US 8,569,448 B2
- Document ID: US8569448B2
- Status: Granted
- Kind: B2
- Application number: 13/190,271
- Filed: 2011-07-25
- Published: 2012-01-12
- Granted: 2013-10-29
- Earliest claimed: 2006-12-12
- Assignees: Grace Laboratories, LLC
- Applicants: Svetlana A. Dambinova
- Inventors: Svetlana A. Dambinova
- Web page: https://patentgrep.com/patent/US8569448B2

## CPC

- G01N 33/9406: {Neurotransmitters}
- A61P 25/00: Drugs for disorders of the nervous system
- G01N 2800/28: Neurological disorders
- G01N: INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES (measuring or testing apparatus or processes other than immunoassay, involving enzymes or microorganisms C12M, C12Q)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

Provided are methods for detecting various subunits and isoforms of NMDA receptors to help diagnose and differentiate (1) the anatomical location of NMDA receptor over-expression. (2) ischemic conditions in the central and peripheral nervous systems, and (3) the type and cause of chronic pain.

## Claims

### Claim 1

An isolated peptide comprising the amino acid sequence of SEQ ID: 1.

### Claim 2

An isolated peptide comprising the amino acid sequence of SEQ ID: 2.

### Claim 3

An isolated peptide comprising the amino acid sequence of SEQ ID: 3.

### Claim 4 (depends on 1)

The peptide of claim 1 linked to a diagnostic substrate or indicator reagent.

### Claim 5 (depends on 2)

The peptide of claim 2 linked to a diagnostic substrate or indicator reagent.

### Claim 6 (depends on 3)

The peptide of claim 3 linked to a diagnostic substrate or indicator reagent.