# US 8,569,445 B2 · Secreted proteins

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- Number: US 8,569,445 B2
- Document ID: US8569445B2
- Status: Granted
- Kind: B2
- Application number: 12/585,371
- Filed: 2009-09-14
- Published: 2010-04-22
- Granted: 2013-10-29
- Earliest claimed: 2000-11-08
- Assignees: Incyte Corporation
- Applicants: Henry Yue; Monique G. Yao; Ameena R. Gandhi; Mariah R. Baughn; Anita Swarnakar; Narinder Chawla; Madhusudan M. Sanjanwala; Michael Thorton; Vicki S. Elliott; Yan Lu; Kimberly J. Gietzen; Neil Burford; Li Ding; April J. A. Hafalia; Y. Tom Tang; Olga Bandman; Bridget A. Warren; Cynthia D. Honchell; Dyung Aina M. Lu; Kavitha Thangavelu; Sally Lee; Yuming Xu; Junming Yang; Preeti G. Lal; Bao Tran; Craig H. Ison; Brendan M. Duggan; Stephanie K. Sapperstein
- Inventors: Henry Yue; Monique G. Yao; Ameena R. Gandhi; Mariah R. Baughn; Anita Swarnakar; Narinder Chawla; Madhusudan M. Sanjanwala; Michael Thorton; Vicki S. Elliott; Yan Lu; Kimberly J. Gietzen; Neil Burford; Li Ding; April J. A. Hafalia; Y. Tom Tang; Olga Bandman; Bridget A. Warren; Cynthia D. Honchell; Dyung Aina M. Lu; Kavitha Thangavelu; Sally Lee; Yuming Xu; Junming Yang; Preeti G. Lal; Bao Tran; Craig H. Ison; Brendan M. Duggan; Stephanie K. Sapperstein
- Web page: https://patentgrep.com/patent/US8569445B2

## CPC

- C12N 15/1055: {Protein x Protein interaction, e.g. two hybrid selection}
- A61K 39/3955: {against proteinaceous materials, e.g. enzymes, hormones, lymphokines}
- A61K 47/64: Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent (peptidic linkers A61K47/65)
- A61K 47/643: {Albumins, e.g. HSA, BSA, ovalbumin or a Keyhole Limpet Hemocyanin [KHL]}
- A61P 9/00: Drugs for disorders of the cardiovascular system
- A61P 25/00: Drugs for disorders of the nervous system
- A61P 29/00: Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P 35/00: Antineoplastic agents
- A61P 37/00: Drugs for immunological or allergic disorders
- C07K 14/47: from mammals
- C07K 14/4711: {Alzheimer's disease; Amyloid plaque core protein}
- C07K 14/4713: {Autoimmune diseases, e.g. Insulin-dependent diabetes mellitus, multiple sclerosis, rheumathoid arthritis, systemic lupus erythematosus; Autoantigens}
- C07K 16/18: against material from animals or humans
- G01N 33/5023: {on expression patterns}
- A61K 2039/505: {comprising antibodies}
- C07K 2317/24: containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
- C07K 2317/54: F(ab')2
- C07K 2317/55: Fab or Fab'
- C07K 2317/622: Single chain antibody (scFv)
- C07K 2317/75: Agonist effect on antigen
- C07K 2317/76: Antagonist effect on antigen, e.g. neutralization or inhibition of binding
- C12N: MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA (microbiological testing media C12Q1/00)
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- C07K: PEPTIDES (peptides in foodstuffs A23; obtaining protein compositions for foodstuffs, working-up proteins for foodstuffs A23J; preparations for medicinal purposes A61K; peptides containing beta-lactam rings C07D; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, C07D; ergot alkaloids of the cyclic peptide type C07D519/02; macromolecular compounds having statistically distributed amino acid units in their molecules, i.e. when the preparation does not provide for a specific; but for a random sequence of the amino acid units, homopolyamides and block copolyamides derived from amino acids C08G69/00; macromolecular products derived from proteins C08H1/00; preparation of glue or gelatine C09H; single cell proteins, enzymes C12N; genetic engineering processes for obtaining peptides C12N15/00; compositions for measuring or testing processes involving enzymes C12Q; investigation or analysis of biological material G01N33/00)
- G01N: INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES (measuring or testing apparatus or processes other than immunoassay, involving enzymes or microorganisms C12M, C12Q)

## Abstract

The invention provides human secreted proteins (SECP) and polynucleotides which identify and encode SECP. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with aberrant expression of SECP.

## Claims

### Claim 1

An isolated polypeptide consisting of amino acids H28-G55 of SEQ ID NO: 6.

### Claim 2 (depends on 1)

A composition comprising the polypeptide of claim 1 and at least one pharmaceutically acceptable excipient or carrier.