Single phase silicone acrylate formulation

A single phase silicone acrylate formulation that resists phase separation and comprises:

• A. at least one of a silicone pressure sensitive adhesive composition, an acrylic pressure sensitive adhesive composition, and combinations thereof;
• and
• B. a silicone acrylate hybrid compatibilizing agent comprising silicone functionality and (meth)acrylate functionality and that is the reaction product of;
• (1) a silicon-containing pressure sensitive adhesive composition, and
• (2) a (meth)acrylate monomer, in the presence of
• (3) an initiator,
• wherein said (1) silicon-containing pressure sensitive adhesive composition comprises the condensation reaction product of;
• (a) a silicone resin,
• (b) a silicone polymer, and
• (c) a silicon-containing capping agent,
• optionally in the presence of a catalyst,
• wherein said (a) silicone resin and said (b) silicone polymer are reacted to form a pressure sensitive adhesive,
• wherein said (c) silicon-containing capping agent is introduced prior to, during, or after said (a) silicone resin and (b) silicone polymer react, and
• wherein;
• said (c) silicon-containing capping agent reacts with said pressure sensitive adhesive after said (a) silicone resin and said (b) silicone polymer have been condensation reacted to form said pressure sensitive adhesive, or
• said (c) silicon-containing capping agent reacts in-situ with said (a) silicone resin and said (b) silicone polymer,
• C. an excipient selected from the group of dipropylene glycol, oleic acid, oleyl alcohol, mineral oil, and combinations thereof, and
• D. a pharmaceutically active agent,
• wherein said single phase formulation comprises about 10 to about 90 weight percent of acrylate content and from about 10 to about 90 weight percent of silicone content.

A method of minimizing phase separation of a single phase silicone acrylate formulation that comprises (A) at least one of a silicone pressure sensitive adhesive composition, an acrylic pressure sensitive adhesive composition, and combinations thereof and (B) a silicone acrylate hybrid compatibilizing agent comprising silicone functionality and (meth)acrylate functionality, said method comprising the step of combining (A) and (B) to form the single phase silicone acrylate formulation wherein the (B) silicone acrylate hybrid compatibilizing agent is the reaction product of;

• (1) a silicon-containing pressure sensitive adhesive composition, and
• (2) a (meth)acrylate monomer, in the presence of
• (3) an initiator,
• wherein the (1) silicon-containing pressure sensitive adhesive composition comprises the condensation reaction product of;
• (a) a silicone resin,
• (b) a silicone polymer, and
• (c) a silicon-containing capping agent,
• optionally in the presence of a catalyst,
• wherein the (a) silicone resin and the (b) silicone polymer are reacted to form a pressure sensitive adhesive,
• wherein the (c) silicon-containing capping agent is introduced prior to, during, or after the (a) silicone resin and (b) silicone polymer react, and
• wherein;
• the (c) silicon-containing capping agent reacts with the pressure sensitive adhesive after the (a) silicone resin and the (b) silicone polymer have been condensation reacted to form the pressure sensitive adhesive, or
• the (c) silicon-containing capping agent reacts in-situ with the (a) silicone resin and the (b) silicone polymer.