Methods for making oxidation-resistant cross-linked polymeric materials
AssigneesThe General Hospital Corporation, Cambridge Polymer Group, Inc.
InventorsOrhun K. Muratoglu, Edward T. Kopesky, Ebru Oral
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Abstract
The present invention relates to methods for making cross-linked oxidation-resistant polymeric materials and preventing or minimizing in vivo elution of antioxidant from the antioxidant-containing polymeric materials. The invention also provides methods of doping polymeric materials with a spatial control of cross-linking and antioxidant distribution, for example, vitamin E (α-Tocopherol), and methods for extraction/elution of antioxidants, for example, vitamin E (α-tocopherol), from surface regions of antioxidant-containing polymeric materials, and materials used therewith also are provided.
Claims35
A method of making an oxidation-resistant cross-linked polymeric material comprising:
- a) blending a polymeric material with an antioxidant, wherein a first portion of the polymeric material is contacted with a concentration of an antioxidant and a second portion of the polymeric material is contacted with another concentration of the antioxidant;
- b) consolidating the antioxidant blended polymeric material, thereby forming a medical implant preform;
- and
- c) irradiating the medical implant preform containing the antioxidant blended polymeric material with ionizing radiation, thereby forming a medical implant preform having an oxidation-resistant cross-linked polymeric material.
A method of making an oxidation-resistant cross-linked polymeric material comprising:
- a) blending a polymeric material with an antioxidant, wherein a first portion of the polymeric resin, flakes, or powder is contacted with a lower concentration of an antioxidant and a second portion of the polymeric resin, flakes, or powder is contacted with a higher concentration of the antioxidant than the first portion, thereby allowing a spatially controlled distribution of the antioxidant-rich and antioxidant-poor regions;
- b) consolidating the antioxidant blended polymeric material, thereby forming a medical implant preform;
- and
- c) irradiating the medical implant preform containing the spatially distributed antioxidant with ionizing radiation, thereby forming a medical implant preform having an oxidation-resistant cross-linked polymeric material having a spatially controlled cross-linking and antioxidant distribution.
A method of making an oxidation-resistant cross-linked medical implant comprising the steps of:
- a) blending one or more types of resin, flakes, or powder with an antioxidant, wherein a first portion of the resin, flakes, or powder are contacted with a concentration of an antioxidant and a second portion of the resin, flakes, or powder are contacted with another concentration of the antioxidant, thereby allowing a spatially controlled distribution of the antioxidant in the polymeric blends;
- and
- b) consolidating the antioxidant-blended resins, flakes, or powders by layering, thereby forming a medical implant.
A method of making an oxidation-resistant cross-linked polymeric material comprising:
- a) blending a polymeric material with an antioxidant, wherein a first portion of the polymeric material is contacted with a concentration of an antioxidant and a second portion of the polymeric material is contacted with another concentration of the antioxidant;
- b) compression molding the antioxidant blended polymeric material to another piece or a medical implant, thereby forming an interface or an interlocked hybrid material;
- and
- c) irradiating the interlocked hybrid material containing the antioxidant with ionizing radiation, thereby forming a medical implant preform having an oxidation-resistant cross-linked polymeric material.
Dependencies are inferred from the claim text.