Antimicrobial compositions
Assignee3M Innovative Properties Company
InventorsRobert A. Asmus, Terry R. Hobbs
Life of this patent
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Abstract
Antimicrobial compositions are provided that include a hydroalcoholic solvent system comprising a lower C2-C5 alcohol and water; a cationic antimicrobial agent such as chlorhexidine gluconate; a fatty component containing at least one free hydroxyl group, such as a C12-C21 fatty alcohol, a C12-C21 fatty ester, a C12-C21 fatty ether, a C12-C21 fatty amide, and combinations thereof; and optionally an emollient ester such as diesters of bibasic acids and trimesters of citric acid. The compositions described herein display improved antimicrobial efficacy and improved cosmetic elegance. Methods of using the antimicrobial compositions are provided.
Claims16
A method of improving the wet adhesion of medical adhesive article, comprising applying a composition comprising:
- a) a C2-C5 lower alcohol present in an amount of at least 35 wt-%;
- b) a fatty component containing one or more free hydroxyl groups selected from the group consisting of C12-C21 fatty alcohols, C12-C21 fatty ethers, C12-C21 fatty amides, and combinations of all of the foregoing;
- wherein the fatty component is present in the composition in an amount of at least 2 wt-%;
- and
- c) a cationic antimicrobial agent present in an amount of at least 0.5 wt-% based upon the total weight of the antimicrobial composition;
- and
- d) water, wherein the lower alcohol to water weight ratio is between 40:60 to 95:5;
- wherein the fatty component and the cationic antimicrobial are dissolved in the antimicrobial composition, and the antimicrobial composition is a solution;
- wherein the antimicrobial composition is free of surfactants with an HLB greater than 6;
- wherein if any component of the composition is ethoxylated, no more than two moles of ethylene oxide are included;
- and
- wherein the antimicrobial composition is essentially free of hydrophilic polymers;
- and
- applying a medical adhesive article over the composition.
A method of improving the wet adhesion of medical adhesive article, comprising applying a composition comprising:
- a) a C2-C5 lower alcohol present in an amount of at least 35 wt-%;
- b) a fatty component containing one or more free hydroxyl groups selected from the group consisting of C12-C21 fatty alcohols, C12-C21 fatty esters, C12-C21 fatty ethers, C12-C21 fatty amides, and combinations of all of the foregoing;
- c) a cationic antimicrobial agent present in an amount of at least 0.5 wt-% based upon the total weight of the antimicrobial composition;
- (d) an emollient ester selected from the group consisting of diesters of bibasic acids, triesters of citric acid, diesters of diols, triesters of triols, and combinations thereof;
- wherein the emollient ester is present in an amount greater than 1 wt-% based on the total weight of the composition;
- and
- e) water, wherein the lower alcohol to water weight ratio is between 40:60 to 95:5;
- wherein the fatty component, the emollient ester, and the cationic antimicrobial are dissolved in the antimicrobial composition, and the antimicrobial composition is a solution;
- and
- applying a medical adhesive article over the composition.
Dependencies are inferred from the claim text.