# US 8,569,382 B2 · Isolated compounds from Phaleria macrocarpa as anti-cancer agents

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- Number: US 8,569,382 B2
- Document ID: US8569382B2
- Status: Granted
- Kind: B2
- Application number: 13/131,261
- Filed: 2009-11-26
- Published: 2011-10-20
- Granted: 2013-10-29
- Earliest claimed: 2008-12-02
- Assignees: Pt. Dexa Medica
- Applicants: Asep Aripin; Poppy Firzani Arifin; Raymond R. Tjandrawinata
- Inventors: Asep Aripin; Poppy Firzani Arifin; Raymond R. Tjandrawinata
- Web page: https://patentgrep.com/patent/US8569382B2

## CPC

- C07H 15/203: Monocyclic carbocyclic rings other than cyclohexane rings; Bicyclic carbocyclic ring systems
- A61K 36/83: Thymelaeaceae (Mezereum family), e.g. leatherwood or false ohelo
- A61P 15/00: Drugs for genital or sexual disorders (for disorders of sex hormones A61P5/24); Contraceptives
- A61P 35/00: Antineoplastic agents
- C07C 49/84: containing ether groups, [IMAGE cpc-sch-C07C-0958.gif] groups,[IMAGE cpc-sch-C07C-0959.gif] groups, or[IMAGE cpc-sch-C07C-0960.gif] groups
- C07H: SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS (derivatives of aldonic or saccharic acids C07C, C07D; aldonic acids, saccharic acids C07C59/105, C07C59/285; cyanohydrins C07C255/16; glycals C07D; compounds of unknown constitution C07G; polysaccharides, derivatives thereof C08B; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification C12N15/00; sugar industry C13)
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- C07C: ACYCLIC OR CARBOCYCLIC COMPOUNDS

## Abstract

The invention concerns compounds DLBS1425E2.2 and DLBS1425F1 isolated and identified from the extract of the plant Phaleria macrocarpa (Scheff.) Boerl. The invention also relates to the use of said compounds, either as a single active compound or in combination, in a pharmaceutical dosage form that has anti-proliferative activity of cancer cells, and its use relating to female related diseases. Formula (I).

## Claims

### Claim 1

A method of treating cancer, comprising:
administering to a subject in need thereof an effective amount of E2.2 compound, wherein said amount is effective as an anti-proliferative agent.

### Claim 2

A method of treating cancer, comprising:
administering to a subject in need thereof an effective amount of E2.2 compound, wherein said amount is effective as an apoptosis inducer.

### Claim 3 (depends on 2)

The method of claim 2 wherein said E2.2 compound downregulates BCl2 mRNA expression.

### Claim 4 (depends on 2)

The method of claim 2 wherein said E2.2 compound upregulates Bax mRNA expression.