# US 8,569,381 B2 · Combination therapy for the management of hypertension

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- Number: US 8,569,381 B2
- Document ID: US8569381B2
- Status: Granted
- Kind: B2
- Application number: 13/262,882
- Filed: 2009-05-22
- Published: 2012-05-10
- Granted: 2013-10-29
- Earliest claimed: 2008-05-23
- Assignees: Targacept, Inc.
- Applicants: Steven M. Toler; David A. Hosford
- Inventors: Steven M. Toler; David A. Hosford
- Web page: https://patentgrep.com/patent/US8569381B2

## CPC

- A61K 45/06: Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A61K 31/13: Amines {(A61K31/04 takes precedence)}
- A61K 31/4178: not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
- A61P 9/00: Drugs for disorders of the cardiovascular system
- A61P 9/12: Antihypertensives
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

The present invention includes a combination comprising: a) mecamylamine; and b) an ACE inhibitor, an AT2 receptor inhibitor, a renin inhibitor, or a combination thereof.

## Claims

### Claim 1

A combination comprising:
a) at least one form of mecamylamine; and
b) an ACE inhibitor, an AT2 receptor inhibitor, a renin inhibitor, a calcium channel blocker, or a combination thereof, wherein the combination provides for a decreased therapeutically effective amount of each component as individually administered.

### Claim 2

A combination comprising:
a) at least one form of mecamylamine; and
b) an ACE inhibitor, an AT2 receptor inhibitor, a renin inhibitor, a calcium channel blocker, or a combination thereof, wherein the mecamylamine is exo-S-mecamylamine.

### Claim 3

A combination comprising:
a) at least one form of mecamylamine; and
b) an ACE inhibitor, an AT2 receptor inhibitor, a renin inhibitor, a calcium channel blocker, or a combination thereof, wherein the AT2 receptor inhibitor is losartan.

### Claim 4

A method for treating or inhibiting the onset of hypertension or refractory hypertension comprising administering:
a) at least one form of mecamylamine; and
b) at least one ACE inhibitor, AT2 receptor inhibitor, a renin inhibitor, a calcium channel blocker, or a combination thereof, wherein the hypertension is angiotensin-induced hypertension.

### Claim 5

A method for treating or inhibiting the onset of hypertension or refractory hypertension comprising administering:
a) at least one form of mecamylamine; and
b) at least one ACE inhibitor, AT2 receptor inhibitor, a renin inhibitor, a calcium channel blocker, or a combination thereof, wherein the administration further reduces one or more of cardiac hypertrophy or fibrosis.

### Claim 6

A method for treating or inhibiting the onset of hypertension or refractory hypertension comprising administering:
a) at least one form of mecamylamine; and
b) at least one ACE inhibitor, AT2 receptor inhibitor, a renin inhibitor, a calcium channel blocker, or a combination thereof, wherein the at least one form of mecamylamine is exo-S-mecamylamine.

### Claim 7

A method for treating or inhibiting the onset of hypertension or refractory hypertension comprising administering:
a) at least one form of mecamylamine; and
b) at least one ACE inhibitor, AT2 receptor inhibitor, a renin inhibitor, a calcium channel blocker, or a combination thereof, wherein the administration further prolongs the control of blood pressure at sustained dosage levels.

### Claim 8

A method for treating or inhibiting the onset of hypertension or refractory hypertension comprising administering:
a) at least one form of mecamylamine; and
b) at least one ACE inhibitor, AT2 receptor inhibitor, a renin inhibitor, a calcium channel blocker, or a combination thereof, wherein the at least one form of mecamylamine and the at least one ACE inhibitor, AT2 receptor inhibitor, a renin inhibitor, a calcium channel blocker, or a combination thereof is administered concomitantly.

### Claim 9

A method for treating or inhibiting the onset of hypertension or refractory hypertension comprising administering:
a) at least one form of mecamylamine; and
b) at least one ACE inhibitor, AT2 receptor inhibitor, a renin inhibitor, a calcium channel blocker, or a combination thereof, wherein the method further comprises diagnosing refractory hypertension by determining a subject's response upon administration.

### Claim 10

A method for treating or inhibiting the onset of hypertension or refractory hypertension comprising administering:
a) at least one form of mecamylamine; and
b) at least one ACE inhibitor, AT2 receptor inhibitor, a renin inhibitor, a calcium channel blocker, or a combination thereof, wherein the AT2 inhibitor is losartan.