US 8,569,380 B2Granted

Oligomer-tricyclic conjugates

AssigneeNektar Therapeutics

InventorsWen Zhang, Xuyuan Gu, Stephanie Allums, Jennifer Riggs-Sauthier

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Abstract

The invention provides small molecule drugs that are chemically modified by covalent attachment of a water soluble oligomer. A conjugate of the invention, when administered by any of a number of administration routes, exhibits characteristics that are different from the characteristics of the small molecule drug not attached to the water soluble oligomer.

Claims7

Dependent claims

A compound selected from one of the following

wherein n is an integer from 1 to 30.

Dependencies are inferred from the claim text.

Facts

Application: 12/744,467Filed 28 Nov 2008 · us provisional application
Priority: 28 Nov 2007
Published: US 2010/0298296 A125 Nov 2010
Granted: 29 Oct 2013
Term ends: Not estimatedThe source records don’t support an estimate.

Classification14 codes

C07D 313/12
Condensed with two six-membered rings: [b,e]-condensed
A61K 47/60
Obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes: the organic…
A61P 25/02
Drugs for disorders of the nervous system: for peripheral neuropathies
A61P 25/08
Drugs for disorders of the nervous system: antiepileptics; Anticonvulsants

Family

Application61/004,483Us provisional application · filed 28 Nov 2007
Application61/191,635Us provisional application · filed 10 Sep 2008
US 2010/0298296 A1Pre-grant publication · published 25 Nov 2010
US 8,569,380 B2This patent

From the US filing history. Foreign family members aren’t listed.

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