# US 8,569,368 B2 · Amino acid compounds

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- Number: US 8,569,368 B2
- Document ID: US8569368B2
- Status: Granted
- Kind: B2
- Application number: 13/465,947
- Filed: 2012-05-07
- Published: 2012-08-30
- Granted: 2013-10-29
- Earliest claimed: 2007-09-18
- Assignees: ThermoLife International, LLC
- Applicants: Ronald Kramer; Alexander Nikolaidis
- Inventors: Ronald Kramer; Alexander Nikolaidis
- Web page: https://patentgrep.com/patent/US8569368B2

## CPC

- C07D 233/64: with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
- A61P 3/00: Drugs for disorders of the metabolism (of the blood or the extracellular fluid A61P7/00)
- A61P 9/08: Vasodilators for multiple indications
- C07D: HETEROCYCLIC COMPOUNDS (macromolecular compounds C08)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

Methods for increasing the bioabsorption of amino acids and for preventing the development of nitrate tolerances in a human or animal are disclosed. The methods include administering to the human or animal a pharmaceutically effective amount of an amino acid compound consisting essentially of a nitrate or nitrite of an amino acid selected from the group consisting of Aspartic Acid, Cysteine, Glycine, Lysine, Methionine, Proline, Tyrosine, Phenylalanine, Carnitine, Taurine, and Betaine.

## Claims

### Claim 1

A method for increasing the bioabsorption of amino acids in a human or animal, the method comprising administering to the human or animal a pharmaceutically effective amount of an amino acid compound consisting essentially of a nitrate or nitrite of an amino acid selected from the group consisting of Aspartic Acid, Cysteine, Glycine, Lysine, Methionine, Proline, Tyrosine, Phenylalanine, Carnitine, Taurine, and Betaine.

### Claim 2

A method for preventing the development of nitrate tolerances in a human or animal, the method comprising administering to the human or animal a pharmaceutically effective amount of an amino acid compound consisting essentially of a nitrate or nitrite of an amino acid selected from the group consisting of Aspartic Acid, Cysteine, Glycine, Lysine, Methionine, Proline, Tyrosine, Phenylalanine, Carnitine, Taurine, and Betaine.