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US 8,569,357 B2Granted
Taxane pro-emulsion formulations and methods making and using the same
AssigneeTeikoku Pharma USA, Inc.
InventorNabeta Kiichiro
Life of this patent
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Abstract
Taxane pro-emulsion formulations are provided. Pro-emulsion formulations are dried powders that include a taxane, oil, surfactant and sugar alcohol. Also provided are methods of making and using the pro-emulsion formulations, as well as kits that include the pro-emulsion formulations.
Claims17
A taxane proemulsion formulation comprising a dried powder comprising a taxane wherein the taxane is described by the formula,
- an oil present in an amount ranging from 0.1-10% by weight;
- a surfactant present in an amount ranging from 10-70% by weight;
- and
- a sugar alcohol;
- wherein the powder is formulated to produce upon combination with an aqueous medium a clear emulsion having a particle size 70 nm or less, that is substantially the same as that of the dried powder's precursor emulsion.
2 more elements
A taxane proemulsion formulation comprising a dried powder comprising a taxane wherein the taxane is described by the formula,
- soybean oil present in an amount ranging from 0.1-10% by weight;
- polysorbate 80 present in an amount ranging from 10-70% by weight;
- propylene glycol and
- mannitol;
- wherein the powder is formulated to produce upon combination with an aqueous medium a clear emulsion having a particle size 70 nm or less, that is substantially the same as that of the dried powder's precursor emulsion.
2 more elements
Dependencies are inferred from the claim text.