# US 8,569,352 B2 · Imidazole based LXR modulators

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- Number: US 8,569,352 B2
- Document ID: US8569352B2
- Status: Granted
- Kind: B2
- Application number: 11/993,529
- Filed: 2006-06-26
- Published: 2010-03-25
- Granted: 2013-10-29
- Earliest claimed: 2005-06-27
- Assignees: Exelixis Patent Company LLC
- Applicants: Brett B. Busch; Brenton T. Flatt; Xiao-Hui Gu; Shao-Po Lu; Richard Martin; Raju Mohan; Michael Charles Nyman; Edwin Schweiger; William C. Stevens, Jr.; Tie-Lin Wang; Yinong Xie
- Inventors: Brett B. Busch; Brenton T. Flatt; Xiao-Hui Gu; Shao-Po Lu; Richard Martin; Raju Mohan; Michael Charles Nyman; Edwin Schweiger; William C. Stevens, Jr.; Tie-Lin Wang; Yinong Xie
- Web page: https://patentgrep.com/patent/US8569352B2

## CPC

- C07D 233/64: with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
- A61P 1/16: for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A61P 3/00: Drugs for disorders of the metabolism (of the blood or the extracellular fluid A61P7/00)
- A61P 3/04: Anorexiants; Antiobesity agents
- A61P 3/06: Antihyperlipidemics
- A61P 3/10: for hyperglycaemia, e.g. antidiabetics
- A61P 9/00: Drugs for disorders of the cardiovascular system
- A61P 9/10: for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A61P 17/00: Drugs for dermatological disorders
- A61P 17/10: Anti-acne agents
- A61P 25/00: Drugs for disorders of the nervous system
- A61P 25/16: Anti-Parkinson drugs
- A61P 25/28: for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A61P 29/00: Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P 35/00: Antineoplastic agents
- A61P 37/00: Drugs for immunological or allergic disorders
- A61P 37/02: Immunomodulators
- A61P 43/00: Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C07D 231/12: with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D 231/22: with aryl radicals attached to ring nitrogen atoms
- C07D 233/90: Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D 401/04: directly linked by a ring-member-to-ring-member bond
- C07D 401/10: linked by a carbon chain containing aromatic rings
- C07D 401/12: linked by a chain containing hetero atoms as chain links
- C07D 401/14: containing three or more hetero rings
- C07D 403/04: directly linked by a ring-member-to-ring-member bond
- C07D 403/10: linked by a carbon chain containing aromatic rings
- C07D 403/12: linked by a chain containing hetero atoms as chain links
- C07D 403/14: containing three or more hetero rings
- C07D 405/10: linked by a carbon chain containing aromatic rings
- C07D 405/12: linked by a chain containing hetero atoms as chain links
- C07D 405/14: containing three or more hetero rings
- C07D 409/04: directly linked by a ring-member-to-ring-member bond
- C07D 409/10: linked by a carbon chain containing aromatic rings
- C07D 409/12: linked by a chain containing hetero atoms as chain links
- C07D 409/14: containing three or more hetero rings
- C07D 413/12: linked by a chain containing hetero atoms as chain links
- C07D 417/10: linked by a carbon chain containing aromatic rings
- C07D 417/12: linked by a chain containing hetero atoms as chain links
- C07D 417/14: containing three or more hetero rings
- C07D 487/08: Bridged systems
- C07D: HETEROCYCLIC COMPOUNDS (macromolecular compounds C08)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

Compounds of the invention, such as compounds of Formulae IIa, IIb, IIc or IId, and pharmaceutically acceptable salts, isomers, and prodrugs thereof, are useful as modulators of the activity of liver X receptors, where R1, R2, R21, R3 and G are defined herein. Pharmaceutical compositions containing the compounds and methods of using the compounds are also disclosed.

## Claims

### Claim 1

A compound according to the formula,
or a pharmaceutically acceptable salt thereof, wherein
R1 is -L1-R5, wherein
L1 is a bond; and
R5 is aryl optionally substituted with one or more R5a; wherein
each R5a is independently halogen, nitro, heteroaryl, heterocyclyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C8 cycloalkyl, (C3-C8 cycloalkyl)-C1-C6 alkyl-, (C3-C8 cycloalkenyl)-C1-C6 alkyl-, (C3-C8 cycloalkyl)-C2-C6 alkenyl-, aryl, arylalkyl, aryloxy, aryloxyaryl, arylC1-6 alkoxy, C1-C6 alkyl, C1-C6 haloalkyl, SO2R11, OR11, SR11, N3, SO2R11, COR11, SO2N(R11)2, SO2NR11COR11, C≡N, C(O)OR11, CON(R11)2, CON(R11)OR11, OCON(R11)2, NR11COR11, NR11CON(R11)2, NR11COOR11, or N(R11)2, wherein
each R5a is optionally substituted with one or more groups which independently are -halogen, —C1-C6 alkyl, aryloxy C0-6 alkylSO2R11, C0-6 alkylCOOR11, C0-6 alkoxyaryl, C1-C6 haloalkyl, —SO2R11, —OR11, —SR11, —N3, —SO2R11, —COR11, —SO2N(R11)2, —SO2NR11COR11, —C≡N, —C(O)OR11, —CON(R11)2, —CON(R11)OR11, —OCON(R11)2, —NR11COR11, —NR11CON(R11)2, —NR11COOR11, or —N(R11)2;
R21 is hydrogen, halogen, nitro, cyano, C1-C6alkyl, or C1-C6haloalkyl;
R2 is —H, —[C(R15)2]m—OH, —C1-C6alkyl, —C1-C6 haloalkyl, halogen, —C(O)N(R11)2, or —COOR11;
provided that R2 and R21 are not simultaneously hydrogen;
J is aryl or heteroaryl;
K is aryl or heteroaryl;
each R4 and R41 is independently halogen, oxo, nitro, CR11═CR11COOR11, aryloxy, aralkyloxy, aryloxyalkyl, arylC0-C6 alkylcarboxy, aryl, heteroaryl, heterocyclyl, heteroaryloxy, heterocyclyloxy, -G1, -E-G1′ or -D-E-G1, wherein
D is —O—;
E is —[C(R15)2]m— or —C3-C8cycloalkyl; and
G1 is —C1-C6alkyl, —C1-C6haloalkyl, —COR11, —COOR11, —CON(R11)2, —C≡N, —OR11, —OCON(R11)2, —OCOOR11, —N3, —NR11COR11, —NR11SO2R11, —N(R11)2, —NR11COOR11, —SO2R11, —SO2NR11COR11, —SO2N(R11)2, —SOR11, or —SR11;
wherein each R4 is optionally substituted with one or more R4a,
wherein each R4a is independently halogen, aryloxy, aralkyloxy, aryloxyalkyl, C1-C6 alkoxyaryl, arylC0-C6 alkylcarboxy, -G′, -E′-G′, or -D′-E′-G′, wherein
D′ is —O—;
E′ is —[C(R15)2]m— or —C3-C8cycloalkyl-; and
G′ is —H, -halogen, —COR11, —COOR11, —COOR11, —C≡N, —OR11, —NR11SO2R11, —SO2R11, —SO2N(R11)2, or —SR11;
L2 is a bond;
each m is 0, 1, 2, 3, 4, 5, or 6;
q is 0, 1, 2, 3, 4, or 5, provided that q is 0 if and only if K is not phenyl; and
q′ is 0, 1, 2, 3, or 4,
each R10 is independently —R11, —C(≡O)R11, —CO2R11, or —SO2R11;
each R11 is independently -hydrogen, —C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C8 cycloalkyl, (C3-C8 cycloalkyl)-C1-C6 alkyl-, (C3-C8 cycloalkenyl)-C1-C6 alkyl-, (C3-C8 cycloalkyl)-C2-C6 alkenyl-, —C1-C6 haloalkyl, —N(R12)2, aryl, —(C1-C6)alkyl-aryl, heteroaryl, —(C1-C6)alkyl-heteroaryl, heterocyclyl, or —(C1-C6)alkyl-heterocyclyl,
wherein any of R11 is optionally substituted with one or more radicals of R12;
each R12 is independently halogen, C1-C6haloalkyl, C1-C6 alkyl, C1-C6 alkoxy, (C0-C6 alkyl)C═O(OR13); C0-C6 alkylOR13, C0-C6 alkylCOR13, C0-C6 alkylSO2R13, C0-C6 alkylCON(R13)2, C0-C6 alkylCONR13OR13, C0-C6 alkylSO2N(R13)2, C0-C6 alkylSR13, C0-C6 haloalkylOR13, aryloxy, aralkyloxy, aryloxyalkyl, C0-6alkoxyaryl, arylC0-6 alkylcarboxy, —C0-C6 alkylN(R13)2, —NR13SO2 R13, or —OC0-6 alkylCOOR13;
each R13 is independently hydrogen, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C8 cycloalkyl, (C3-C8 cycloalkyl)-C1-C6 alkyl-, (C3-C8 cycloalkenyl)-C1-C6 alkyl-, or (C3-C8 cycloalkyl)-C2-C6 alkenyl-;
and each R15 is independently hydrogen, halogen, (C1-C6)alkyl, (C3-C6)cycloalkyl, or (C1-C6)haloalkyl.

### Claim 2 (depends on 1)

The compound according to claim 1, wherein at least one of J and K is phenyl.

### Claim 3 (depends on 2)

The compound according to claim 2, of the formula,
or a pharmaceutically acceptable salt thereof.

### Claim 4 (depends on 3)

The compound according to claim 3, of the formula,
or a pharmaceutically acceptable salt thereof, wherein R21 is —H, -halogen, —C1-C6alkyl, or —C1-C6haloalkyl.

### Claim 5 (depends on 3)

The compound according to claim 3 wherein
each R4 is independently halogen, aryl, heteroaryl, heterocyclyl, -G1, or -E-G1, wherein
E is —[C(R15)2]m—, wherein each R15 is independently hydrogen or halogen; and
G1 is —C1-C6alkyl, —C1-C6haloalkyl, —OR11, or —SO2R11.

### Claim 6 (depends on 3)

The compound according to claim 3, wherein
each R41 is independently halogen, -G2, or -E-G2, wherein
E is —[C(R15)2]m—, wherein each R15 is independently hydrogen or halogen; and
G2 is —C1-C6alkyl, —C1-C6haloalkyl, or halogen; and
each R4 is independently halogen, aryl, heteroaryl, heterocyclyl, -G1, or -E-G1, wherein
E is —[C(R15)2]m—, wherein each R15 is independently hydrogen or halogen; and
G1 is —C1-C6alkyl, —C1-C6haloalkyl, —OR11, or —SO2R11.

### Claim 7 (depends on 4)

The compound according to claim 4, wherein each R5a is independently halogen, C1-C6 alkyl, C1-C6 haloalkyl, C3-C8cycloalkyl, OR11, SO2R11, COR11, SO2N(R11)2, C≡N, C(O)OR11, CON(R11)2, NR11 COR11, or N(R11)2.

### Claim 8

A compound according to the formula,
or a pharmaceutically acceptable salt thereof, wherein,
L1 is —[C(R15)2]m′— or —C3-C8 cycloalkyl; wherein m′ is any of 1 to 3; and
each R15 is independently hydrogen, halogen, (C1-C6)alkyl, or (C1-C6)haloalkyl;
R5 is aryl, heterocyclyl, heteroaryl, —(C3-C6)cycloalkyl, —C, or —B—C, wherein
B is —[C(R15)2]m— or —C3-C8 cycloalkyl-; and
C is halogen, —C1-C6alkyl, —C1-C6haloalkyl, —SO2R11, —SR11, —SO2N(R11)2, —SO2NR11COR11, —C≡N, —C(O)OR11, —CON(R11)2, or —N(R11)2,
wherein R5 is optionally substituted with one or more R5a, wherein
each R5a is independently halogen, nitro, heteroaryl, heterocyclyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C8 cycloalkyl, (C3-C8 cycloalkyl)-C1-C6 alkyl-, (C3-C8 cycloalkenyl)-C1-C6 alkyl-, (C3-C8 cycloalkyl)-C2-C6 alkenyl-, aryl, arylalkyl, aryloxy, aryloxyaryl, arylC1-6 alkoxy, C1-C6 alkyl, C1-C6 haloalkyl, SO2R11, OR11, SR11, N3, SO2R11, COR11, SO2N(R11)2, SO2NR11COR11, C≡N, C(O)OR11, CON(R11)2, CON(R11)OR11, OCON(R11)2, NR11COR11, NR11CON(R11)2, NR11COOR11, or N(R11)2, wherein
each R5a is optionally substituted with one or more groups which independently are -halogen, —C1-C6 alkyl, aryloxy C0-6 alkylSO2R11, C0-6 alkylCOOR11, C0-6 alkoxyaryl, C1-C6 haloalkyl, —SO2R11, —OR11, —SR11, —N3, —SO2R11, —COR11, —SO2N(R11)2, —SO2NR11COR11, —C≡N, —C(O)OR11, —CON(R11)2, —CON(R11)OR11, —OCON(R11)2, —NR11COR11, —NR11CON(R11)2, —NR11COOR11, or —N(R11)2;
R21 is hydrogen, halogen, nitro, cyano, C1-C6alkyl, or C1-C6haloalkyl;
R2 is —H, —[C(R15)2]m—OH, —C1-C6alkyl, —C1-C6 haloalkyl, halogen, —C(O)N(R11)2, or —COOR11;
provided that R2 and R21 are not simultaneously hydrogen;
J and K are both phenyl;
each R4 and R41 is independently halogen, oxo, nitro, CR11═CR11COOR11, aryloxy, aralkyloxy, aryloxyalkyl, arylC0-C6 alkylcarboxy, aryl, heteroaryl, heterocyclyl, heteroaryloxy, heterocyclyloxy, -G1, -E-G1′ or -D-E-G1, wherein
D is —O—;
E is —[C(R15)2]m— or —C3-C8cycloalkyl; and
G1 is —C1-C6alkyl, —C1-C6haloalkyl, —COR11, —COOR11, —CON(R11)2, —C≡N, —OR11, —OCON(R11)2, —OCOOR11, —N3, —NR11COR11, —NR11SO2R11, —N(R11)2, —NR11COOR11, —SO2R11, —SO2NR11COR11, —SO2N(R11)2, —SOR11, or —SR11;
wherein each R4 is optionally substituted with one or more R4a,
wherein each R4a is independently halogen, aryloxy, aralkyloxy, aryloxyalkyl, C1-C6 alkoxyaryl, arylC0-C6 alkylcarboxy, -G′, -E′-G′, or -D′-E′-G′, wherein
D′ is —O—;
E′ is —[C(R15)2]m— or —C3-C8cycloalkyl-; and
G′ is —H, -halogen, —COR11, —COOR11, —C≡N, OR11, —NR11SO2R11, —SO2R11, —SO2N(R11)2, or —SR11;
L2 is a bond or —[C(R15)2]m—V2—[C(R15)2]n—, wherein
V2 is independently —C(R11)2—, —C(R11)2C(R11)2—, —C(R11)═C(R11)—, —C(R11)2O—, —C(R11)2NR11—, —C≡C—, —O—, —S—, —SO2—, —N(R10)CO—, —N(R10)CO2—, —CON(R10)—, —CON(R11)—, —CON(R11)O—, —CO—, —CS—, —CO2—, —OC(═O)—, —OC(═O)N(R10)—, —N(R10)SO2—, —SO2N(R10)—, —NR10CONR10—, —NR10CSNR10—, C3-C6cycloalkyl-, or C3-C6cyclohaloalkyl, or V2 is C2-6 alidiyl,
wherein alidiyl chain is optionally interrupted by —C(R11)2—, —C(R11)2C(R11)2—, —C(R11)═C(R11)—, —C(R11)2O—, —C(R11)2NR11—, —C(R11)2NR11—, —C≡C—, —O—, —S—, —N(R10)CO—, —N(R10)CO2—, —CON(R10)—, —CON(R11)—, —CON(R11)O—, —CO—, —CO2—, —OC(═O)—, —OC(═O)N(R10)—, —SO2—, —N(R10)SO2— or —SO2N(R10)—;
or V2 is aryl, heteroaryl, or heterocyclyl, each of which is optionally substituted with one or more R9, wherein
each R9 is independently halogen, C1-C6 haloalkyl, C1-C6 alkyl, C1-C6 alkyloxy, C0-C6 alkyl or C1-C6 alkylCOOR11;
each m is 0, 1, 2, 3, 4, 5, or 6;
q is 1, 2, 3, 4, or 5,
q′ is 0, 1, 2, 3, or 4,
each R10 is independently —R11, —C(═O)R11, —CO2R11, or —SO2R11;
each R11 is independently -hydrogen, —C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C8 cycloalkyl, (C3-C8 cycloalkyl)-C1-C6 alkyl-, (C3-C8 cycloalkenyl)-C1-C6 alkyl-, (C3-C8 cycloalkyl)-C2-C6 alkenyl-, —C1-C6 haloalkyl, —N(R12)2, aryl, —(C1-C6)alkyl-aryl, heteroaryl, —(C1-C6)alkyl-heteroaryl, heterocyclyl, or —(C1-C6)alkyl-heterocyclyl,
wherein any of R11 is optionally substituted with one or more radicals of R12;
each R12 is independently halogen, C1-C6haloalkyl, C1-C6 alkyl, C1-C6 alkoxy, (C0-C6 alkyl)C═O(OR13); C0-C6 alkylOR13, C0-C6 alkylCOR13, C0-C6 alkylSO2R13, C0-C6 alkylCON(R13)2, C0-C6 alkylCONR13OR13, C0-C6 alkylSO2N(R13)2, C0-C6 alkylSR13, C0-C6 haloalkylOR13, aryloxy, aralkyloxy, aryloxyalkyl, C0-6alkoxyaryl, arylC0-6 alkylcarboxy, —C0-C6 alkylN(R13)2, —NR13SO2R13, or —OC0-6 alkylCOOR13; and
each R13 is independently hydrogen, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C8 cycloalkyl, (C3-C8 cycloalkyl)-C1-C6 alkyl-, (C3-C8 cycloalkenyl)-C1-C6 alkyl-, or (C3-C8 cycloalkyl)-C2-C6 alkenyl.

### Claim 9 (depends on 8)

The compound according to claim 8, wherein L2 is a bond.

### Claim 10 (depends on 9)

The compound according to claim 9, of the formula,
or a pharmaceutically acceptable salt thereof.

### Claim 11 (depends on 10)

The compound according to claim 10, wherein
each R15 is independently —H or —(C1-C2)alkyl;
m′ is 1 or 2; and
R5 is phenyl optionally substituted with one or more R5a.

### Claim 12 (depends on 11)

The compound according to claim 11, wherein
each R4 is independently halogen, aryl, heteroaryl, heterocyclyl, -G1, or -E-G1, wherein
E is —[C(R15)2]m—, wherein each R15 is independently hydrogen or halogen; and
G1 is —C1-C6alkyl, —C1-C6haloalkyl, —OR11, or —SO2R11.

### Claim 13 (depends on 11)

The compound according to claim 11, wherein
each R41 is independently halogen, -G1, or -E-G1, wherein
E is —[C(R15)2]m—, wherein each R15 is independently hydrogen or halogen; and
G1 is —C1-C6alkyl or —C1-C6haloalkyl.

### Claim 14 (depends on 10)

The compound according to claim 10, wherein
R15 is —H;
m is 1, 2, or 3; and
R5 is heterocyclyl optionally substituted with one or more R5a.

### Claim 15 (depends on 14)

The compound according to claim 14, wherein
each R4 is independently halogen, aryl, heteroaryl, heterocyclyl, -G1, or -E-G1, wherein
E is —[C(R15)2]m—, wherein each R15 is independently hydrogen or halogen; and
G1 is —C1-C6alkyl, —C1-C6haloalkyl, —OR11, or —SO2R11.

### Claim 16 (depends on 14)

The compound according to claim 14, wherein
each R41 is independently halogen, -G1, or -E-G1, wherein
E is —[C(R15)2]m—, wherein each R15 is independently hydrogen or halogen; and
G1 is —C1-C6alkyl or —C1-C6haloalkyl.

### Claim 17

A compound according to one of the following formulas,
or a pharmaceutically acceptable salt thereof, wherein,
R1 is -L1-R5, wherein
L1 is a bond, —[C(R15)2]m—, or —C3-C8 cycloalkyl-; and
R5 is phenyl or pyridyl, each optionally substituted with one or two R5a, wherein
each R5a is independently -halogen, —C1-C6 alkoxy, —C1-C6 alkyl, or —C1-C6haloalkyl;
R2, R21, and R3 are each independently —H, —[C(R15)2]m—OH, —C1-C6 alkyl, —C1-C6 haloalkyl, halogen, —C(O)N(R11)2, or —COOR11;
provided that R2 and R21 are not simultaneously hydrogen;
G is a group of the formula,
wherein
L2 is a bond;
J is phenyl, pyridyl, or thienyl;
K is phenyl or pyridyl;
q is 0, 1, 2, 3, 4, or 5, provided that q is 0 if and only if K is not phenyl;
q′ is 0, 1, 2, 3, or 4,
each R41 is -halogen, —C1-C6 alkyl, or C1-C6 -haloalkyl; and
each R4 is -halogen, —[C(R15)2]m—OH, —SO2R11, —SO2N(R11)2, —C(O)N(R11)2, —COOR11, —C1-C6 alkyl, or —C1-C6 haloalkyl;
each m is 0, 1, 2, 3, 4, 5, or 6;
each R15 is independently hydrogen, halogen, (C1-C6)alkyl, (C3-C6)cycloalkyl, or (C1-C6)haloalkyl; and
each R11 is independently -hydrogen, —C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C8 cycloalkyl, (C3-C8 cycloalkyl)-C1-C6 alkyl-, (C3-C8 cycloalkenyl)-C1-C6 alkyl-, (C3-C8 cycloalkyl)-C2-C6 alkenyl-, —C1-C6 haloalkyl, —N(R12)2, heterocyclyl, or —(C1-C6)alkyl-heterocyclyl, wherein any of R11 is optionally substituted with one or more radicals of R12;
each R12 is independently halogen, C1-C6haloalkyl, C1-C6 alkyl, C1-C6 alkoxy, (C0-C6 alkyl)C═O(OR13); C0-C6 alkylOR13, C0-C6 alkylCOR13, C0-C6 alkylSO2R13, C0-C6 alkylCON(R13)2, C0-C6 alkylCONR13OR13, C0-C6 alkylSO2N(R13)2, C0-C6 alkylSR13, C0-C6 haloalkylOR13, aryloxy, aralkyloxy, aryloxyalkyl, C0-6 alkoxyaryl, arylC0-6 alkylcarboxy, -C0-C6 alkylN(R13)2, —NR13SO2 R13, or —OC0-6 alkylCOOR13; and
each R13 is independently hydrogen, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C8 cycloalkyl, (C3-C8 cycloalkyl)-C1-C6 alkyl-, (C3-C8 cycloalkenyl)-C1-C6 alkyl-, or (C3-C8 cycloalkyl)-C2-C6 alkenyl-.

### Claim 18 (depends on 10)

The compound according to claim 10, wherein
each R15 is independently —H or —(C1-C2)alkyl;
m′ is 1 or 2; and
R5 is heteroaryl optionally substituted with one or more R5a.

### Claim 19 (depends on 18)

The compound according to claim 18, wherein
each R4 is independently halogen, aryl, heteroaryl, heterocyclyl, -G1, or -E-G1, wherein
E is —[C(R15)2]m—, wherein
each R15 is independently hydrogen or halogen; and
G1 is —C1-C6alkyl, —C1-C6haloalkyl, —OR11, or —SO2R11.

### Claim 20 (depends on 18)

The compound according to claim 18, wherein
each R41 is independently halogen, -G1, or -E-G1, wherein
E is —[C(R15)2]m—,
wherein each R15 is independently hydrogen or halogen; and
G1 is —C1-C6alkyl or —C1-C6haloalkyl.

### Claim 21

A compound according to the formula,
or a pharmaceutically acceptable salt thereof, wherein
L1 is —[C(R15)2]m— or —C3-C8 cycloalkyl; wherein m' is 1 or 2; and
R5 is heteroaryl optionally substituted with one or more R5a, wherein
each R5a is independently halogen, nitro, heteroaryl, heterocyclyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C8 cycloalkyl, (C3-C8 cycloalkyl)-C1-C6 alkyl-, (C3-C8 cycloalkenyl)-C1-C6 alkyl-, (C3-C8 cycloalkyl)-C2-C6 alkenyl-, aryl, arylalkyl, aryloxy, aryloxyaryl, arylC1-6 alkoxy, C1-C6 alkyl, C1-C6 haloalkyl, SO2R11, OR11, SR11, N3, SO2R11, COR11, SO2N(R11)2, SO2NR11COR11, C≡N, C(O)OR11, CON(R11)2, CON(R11)OR11 , OCON(R11)2, NR11COR11, NR11CON(R11)2, NR11COOR11, or N(R11)2, wherein
each R5a is optionally substituted with one or more groups which independently are -halogen, —C1-C6 alkyl, aryloxy C0-6 alkylSO2R11, C0-6 alkylCOOR11, C0-6 alkoxyaryl, C1-C6 haloalkyl, —SO2R11, —OR11, —SR11, —N3, —SO2R11, —COR11, —SO2N(R11)2, —SO2NR11COR11, —C≡N, —C(O)OR11, —CON(R11)2, —CON(R11)OR11, —OCON(R11)2, —NR11COR11, —NR11CON(R11)2, —NR11COOR11, or —N(R11)2;
R21 is hydrogen, halogen, nitro, cyano, C1-C6alkyl, or C1-C6haloalkyl;
R2 is —H, —[C(R15)2]m—OH, —C1-C6 alkyl, —C1-C6 haloalkyl, halogen, —C(O)N(R11)2, or —COOR11;
provided that R2 and R21 are not simultaneously hydrogen;
each m is 0, 1, 2, 3, 4, 5, or 6;
q is 1, 2, 3, 4, or 5,
q′ is 0, 1, 2, 3, or 4, and
each R4 and R41 is independently halogen, oxo, nitro, CR11═CR11COOR11, aryloxy, aralkyloxy, aryloxyalkyl, arylC0-C6 alkylcarboxy, aryl, heteroaryl, heterocyclyl, heteroaryloxy, heterocyclyloxy, -G1, -E-G1′ or -D-E-G1, wherein
D is —O—;
E is —[C(R15)2]m— or —C3-C8cycloalkyl; and
G1 is —C1-C6alkyl, —C1-C6haloalkyl, —COR11, —COOR11, —CON(R11)2, —C≡N, —OR11, —OCON(R11)2, —OCOOR 11, —N3, —NR11COR11, —NR11SO2R11, —N(R11)2, —NR11COOR11, —SO2R11, —SO2NR11COR11, —SO2N(R11)2, —SOR11, or —SR11;
wherein each R4 is optionally substituted with one or more R4a,
wherein each R4a is independently halogen, aryloxy, aralkyloxy, aryloxyalkyl, C1-C6 alkoxyaryl, arylC0-C6 alkylcarboxy, -G′, -E′-G′, or-D′-E′-G′, wherein
D′ is —O—;
E′ is —[C(R15)2]M— or —C3-C8cycloalkyl-; and
G′ is —H, -halogen, —COR11, —COOR11, —C≡N, OR11, —NR11SO2R11, —SO2R11, —SO2N(R11)2, or —SR11;
each R11 is independently -hydrogen, —C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C8 cycloalkyl, (C3-C8 cycloalkyl)-C1-C6 alkyl-, (C3-C8 cycloalkenyl)-C1-C6 alkyl-, (C3-C8 cycloalkyl)-C2-C6 alkenyl-, -C1-C6 haloalkyl, —N(R12)2, aryl, -(C1-C6)alkyl-aryl, heteroaryl, —(C1-C6)alkyl-heteroaryl, heterocyclyl, or —(C1-C6)alkyl-heterocyclyl,
wherein any of R11 is optionally substituted with one or more radicals of R12;
each R12 is independently halogen, C1-C6haloalkyl, C1-C6 alkyl, C1-C6 alkoxy, (C0-C6 alkyl)C═O(OR13); C0-C6 alkylOR13, C0-C6 alkylCOR13, C0-C6 alkylSO2R13, C0-C6 alkylCON(R13)2, C0-C6 alkylCONR13OR13, C0-C6 alkylSO2N(R13)2, C0-C6 alkylSR13, C0-C6 haloalkylOR13, aryloxy, aralkyloxy, aryloxyalkyl, C0-6alkoxyaryl, arylC0-6 alkylcarboxy, —C0-C6 alkylN(R13)2, —NR13SO2 R13, or —OC0-6 alkylCOOR13;
each R13 is independently hydrogen, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C8 cycloalkyl, (C3-C8 cycloalkyl)-C1-C6 alkyl-, (C3-C8 cycloalkenyl)-C1-C6 alkyl-, or (C3-C8 cycloalkyl)-C2-C6 alkenyl-;
and each R15 is independently H, halogen, or (C1-C6)alkyl.

### Claim 22 (depends on 21)

The compound according to claim 21, wherein
each R4 is independently halogen, aryl, heteroaryl, heterocyclyl, -G1, or -E-G1, wherein
E is —[C(R15)2]m—, wherein each R15 is independently hydrogen or halogen; and
G1 is —C1-C6alkyl, —C1-C6haloalkyl, —OR11, or —SO2R11.

### Claim 23

A compound according to one of the following formulas,
or a pharmaceutically acceptable salt thereof, wherein,
R1 is -L1-R5, wherein
L1 is a bond, —C3-C8 cycloalkyl- or L5, wherein
each L5 is independently —[C(R15)2]m—, wherein
m is 0, 1, 2, or 3; and
each R15 is independently hydrogen, halogen, (C1-C6)alkyl, or (C1-C6)haloalkyl; and
R5 is aryl, heterocyclyl, heteroaryl, —C, or -B-C, wherein
B is —[C(R15)2]m—, —C3-C6cycloalkyl-; and
C is —C1-C6alkyl or —C1-C6haloalkyl;
wherein R5 is optionally substituted with one or more R5a, wherein
each R5a is independently halogen, nitro, heteroaryl, heterocyclyl, C2-C6 alkenyl, C2-C6 alkynyl, (C3-C8 cycloalkyl)-C1-C6 alkyl-, (C3-C8 cycloalkenyl)-C1-C6 alkyl-, (C3-C8 cycloalkyl)-C2-C6 alkenyl-, aryl, arylalkyl, aryloxy, aryloxyaryl, arylC1-6 alkoxy, C1-C6 alkyl, C1-C6 haloalkyl, C3-C6cycloalkyl, SO2R11, OR11, SR11, N3, SO2R11, COR11, SO2N(R11)2, SO2NR11COR11, C≡N, C(O)OR11, CON(R11)2, CON(R11)OR11, OCON(R11)2, NR11COR11, NR11CON(R11)2, NR11COOR11, or N(R11)2, wherein
each R5a is optionally substituted with one or more groups which independently are -halogen, —C1-C6 alkyl, aryloxy, C0-6 alkylSO2R11, C0-6 alkylCOOR11, C0-6 alkoxyaryl, —C1-C6 haloalkyl, —SO2R11, OR11, —SR11, —N3, —SO2R11, —COR11, —SO2N(R11)2, —SO2NR11COR11, —C≡N, —C(O)O R11, —CON(R11)2, —CON(R11)OR11, —OCON(R11)2, —NR11COR11, —NR11CON(R11)2, —NR11COOR11, or —N(R11)2;
R2 is —H, —[C(R15)2]m—OH, —C1-C6alkyl, —C1-C6 haloalkyl, halogen, —C(O)N(R11)2, or —COOR11;
R21 is hydrogen, halogen, C1-C6 alkyl, or C1-C6 haloalkyl; and
provided that R2 and R21 are not simultaneously hydrogen;
G is a group of the formula,
wherein
J is aryl or heteroaryl;
K is aryl or heteroaryl;
each R4 and R41 is independently halogen, heteroaryl, heterocyclyl, -G1, -E- G1, or -D-E- G1,
wherein
D is —O—;
E is —[C(R15)2]m— or —C3-C6cycloalkyl; and
G1 is —C1-C6alkyl, —C1-C6haloalkyl, —COR11, —COOR11, —CON(R11)2, —C≡N, —OR11, —SOR11, —SO2R11, —SO2N(R11)2, or —SR11,
L2 is a bond;
q is 1, 2, or 3, and
q′ is 0, 1, 2 or 3,
each R11 is independently -hydrogen, —C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, (C3-C8 cycloalkyl)-C1-C6 alkyl-, (C3-C8 cycloalkenyl)-C1-C6 alkyl-, (C3-C8 cycloalkyl)-C2-C6 alkenyl-, —C3-C8 cycloalkyl, —(C1-C6)alkyl-(C3-C8)cycloalkyl, —C1-C6 haloalkyl, —N(R12)2, aryl, —(C1-C6)alkyl-aryl, heteroaryl, —(C1-C6)alkyl-heteroaryl, heterocyclyl, or —(C1-C6)alkyl-heterocyclyl, wherein any of R11 is optionally substituted with one or more radicals of R12;
each R12 is independently halogen, OR13, N(R13)2, C1-C6haloalkyl, C1-C6 alkyl, C1-C6 alkoxy, C0-C6 alkylOR13, C0-C6 alkylCOR13, C0-C6 alkylSO2R13, C0-C6 alkylCON(R13)2, C0-C6 alkylCONR13OR13, C0-C6 alkylSO2N(R13)2, C0-C6 alkylSR13, C0-C6 haloalkylOR13, aryloxy, aralkyloxy, aryloxyalkyl, C0-6alkoxyaryl, arylC0-6 alkylcarboxy, C0-C6 alkyl, —NR13SO2 R13, or —OC0-6 alkylCOOR13;
each R13 is independently hydrogen C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, (C3-C8 cycloalkyl) C1-C6 alkyl-, (C3-C8 cycloalkenyl)-C1-C6 alkyl-, or (C3-C8 cycloalkyl)-C2-C6 alkenyl-.

### Claim 24

A compound which is one of the species selected from the group consisting of:
Cpd #
Structure
Name
1
2-(2-(2-fluorobenzyl)-1-(3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
2
2-(1-(3′- (methylsulfonyl)biphenyl- 4-yl)-2-(2- (trifluoromethyl)benzyl)- 1H-imidazol-4- yl)propan-2-ol;
3
2-(2-(2-chlorobenzyl)-1-(3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
4
2-(2-(2-chlorobenzyl)-1-(3′- (ethylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
5
2-(2-(2-chlorobenzyl)- 1-(4′-(hydroxymethyl)-3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
6
2-(2-(2,6- dichlorobenzyl)-1-(3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
7
2-(2-(2,6- dichlorobenzyl)-1-(3′- (ethylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
8
2-(2-(2,6- dichlorobenzyl)-1-(3′- (ethylsulfonyl)-4′- (hydroxymethyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
9
2-(2-(2-chloro-6- fluorobenzyl)-1-(3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
10
2-(2-(2-chloro-6- fluorobenzyl)-1-(3′- (ethylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
11
2-(2-(2,3- dichlorobenzyl)-1-(3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
12
2-(2-(2,3- dichlorobenzyl)-1-(3′- (ethylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
13
3-(2-(2-chlorobenzyl)-1-(3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)pentan-3-ol;
14
3-(2-(2-chlorobenzyl)-1-(3′- (ethylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)pentan-3-ol;
15
3-(2-(2-chlorobenzyl)- 1-(4′-(hydroxymethyl)-3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)pentan-3-ol;
16
2-(2-(5-chloro-2- (trifluoromethyl)benzyl)- 1-(3′-(methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
17
2-(2-(5-chloro-2- (trifluoromethyl)benzyl)- 1-(3′-(ethylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
18
2-(2-(5-chloro-2- (trifluoromethyl)benzyl)- 1-(4′-(hydroxymethyl)-3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
19
2-(2-(2-(2- chlorophenyl)propan-2- yl)-1-(3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
20
2-(2-(2-(2- chlorophenyl)propan-2- yl)-1-(3′- (ethylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
21
2-(2-(2-(2,3- dichlorophenyl)propan- 2-yl)-1-(3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
22
2-(2-(2-(2,3- dichlorophenyl)propan- 2-yl)-1-(3′- (ethylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
23
2-(2-(2,3- dichlorobenzyl)-1-(3- methyl-3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
24
2-(2-(2,3- dichlorobenzyl)-1-(3′- (ethylsulfonyl)-3- methylbiphenyl-4-yl)- 1H-imidazol-4- yl)propan-2-ol;
25
2-(1-(3-chloro-3′- (methylsulfonyl)biphenyl- 4-yl)-2-(2,3- dichlorobenzyl)-1H- imidazol-4-yl)propan-2-ol;
26
2-(1-(3-chloro-3′- (ethylsulfonyl)biphenyl- 4-yl)-2-(2,3- dichlorobenzyl)-1H- imidazol-4-yl)propan-2-ol;
27
2-(2-(2- chlorophenethyl)-1-(3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
28
2-(2-(2- chlorophenethyl)-1-(3′- (ethylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
29
2-(2-(2- chlorophenethyl)-1-(4′- (hydroxymethyl)-3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
30
2-(1-(3-chloro-3′- (methylsulfonyl)biphenyl- 4-yl)-2-(naphthalen- 1-yl)-1H-imidazol-4- yl)propan-2-ol;
31
2-(1-(3-chloro-3′- (ethylsulfonyl)biphenyl- 4-yl)-2-(naphthalen-1- yl)-1H-imidazol-4- yl)propan-2-ol;
32
2-(1-(3-chloro-4′- (hydroxymethyl)-3′- (methylsulfonyl)biphenyl- 4-yl)-2-(naphthalen- 1-yl)-1H-imidazol-4- yl)propan-2-ol;
33
2-(1-(3-chloro-3′- (methylsulfonyl)biphenyl- 4-yl)-2-(isoquinolin- 1-yl)-1H-imidazol-4- yl)propan-2-ol;
34
2-(1-(3-chloro-3′- (ethylsulfonyl)biphenyl- 4-yl)-2-(isoquinolin-1- yl)-1H-imidazol-4- yl)propan-2-ol;
35
2-(2-(isoquinolin-5-yl)- 1-(3-methyl-3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
36
2-(1-(3′-(ethylsulfonyl)- 3-methylbiphenyl-4-yl)- 2-(isoquinolin-5-yl)- 1H-imidazol-4- yl)propan-2-ol;
37
2-(1-(3′- (methylsulfonyl)biphenyl- 4-yl)-2-(4- (trifluoromethyl)pyridin- 3-yl)-1H-imidazol-4- yl)propan-2-ol;
38
2-(1-(3′- (ethylsulfonyl)biphenyl- 4-yl)-2-(4- (trifluoromethyl)pyridin- 3-yl)-1H-imidazol-4- yl)propan-2-ol;
39
2-(1-(4′- (hydroxymethyl)-3′- (methylsulfonyl)biphenyl- 4-yl)-2-(4- (trifluoromethyl)pyridin- 3-yl)-1H-imidazol-4- yl)propan-2-ol;
40
2-(1-(3′- (methylsulfonyl)biphenyl- 4-yl)-2-(2- morpholinoethyl)-1H- imidazol-4-yl)propan-2-ol;
41
2-(1-(3-methyl-3′- (methylsulfonyl)biphenyl- 4-yl)-2-(thiophen-2- yl)-1H-imidazol-4- yl)propan-2-ol;
42
2-(2-(1,5-dimethyl-1H- pyrrol-2-yl)-1-(3- methyl-3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
43
2-(2-(1,5-dimethyl-1H- pyrrol-2-yl)-1-(3- methyl-3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
44
2-(1-(2,6- dichlorophenyl)-2-(5-(3- (methylsulfonyl)phen- yl)thiophen-2-yl)-1H- imidazol-4-yl)propan-2-ol;
45
2-(1-(2,6- dichlorophenyl)-2-(5-(3- (ethylsulfonyl)phen- yl)thiophen-2-yl)-1H- imidazol-4-yl)propan-2-ol;
46
1-(2,5-dichlorophenyl)- 2-{5-[3- (methylsulfonyl)phen- yl]-2-thienyl}-4- (trifluoromethyl)-1H- imidazole;
47
1-(2-chlorophenyl)-2- {5-[3- (methylsulfonyl)phenyl]- 2-thienyl}-4- (trifluoromethyl)-1H- imidazole;
48
methyl (4-{5-[1-(2- chlorophenyl)-4- (trifluoromethyl)-1H- imidazol-2-yl]-2- thienyl}-3- methylphenyl)acetate;
49
5-{5-[1-(2,5- dichlorophenyl)-4- (trifluoromethyl)-1H- imidazol-2-yl]-2- thienyl}-2-(ethylthio)-3- methylpyridine;
50
5-{5-[1-(2,5- dichlorophenyl)-4- (trifluoromethyl)-1H- imidazol-2-yl]-2- thienyl}-2- (ethylsulfonyl)-3- methylpyridine;
51
5-{5-[1-(2,5- dichlorophenyl)-4- (trifluoromethyl)-1H- imidazol-2-yl]-2- thienyl}-3-methyl-2- (methylsulfonyl)pyridine;
52
4-(5-{5-[1-(2,5- dichlorophenyl)-4- (trifluoromethyl)-1H- imidazol-2-yl]-2- thienyl}pyridin-2- yl)morpholine;
53
1,1-dimethylethyl 4-(5- {5-[1-(2,5- dichlorophenyl)-4- (trifluoromethyl)-1H- imidazol-2-yl]-2- thienyl}pyridin-2- yl)piperazine-1- carboxylate;
54
1-(5-{5-[1-(2,5- dichlorophenyl)-4- (trifluoromethyl)-1H- imidazol-2-yl]-2- thienyl}pyridin-2- yl)piperazine;
55
5-{5-[1-(2- chlorophenyl)-4- (trifluoromethyl)-1H- imidazol-2-yl]-2- thienyl}-2-(ethylthio)-3- methylpyridine;
56
5-{5-[1-(2- chlorophenyl)-4- (trifluoromethyl)-1H- imidazol-2-yl]-2- thienyl}-3-methyl-2- (methylsulfonyl)pyridine;
57
5-{5-[1-(2- chlorophenyl)-4- (trifluoromethyl)-1H- imidazol-2-yl]-2- thienyl}-2- (ethylsulfonyl)-3- methylpyridine;
58
2-(1-(2,6- dichlorophenyl)-2-(3′- (ethylsulfonyl)-3- methylbiphenyl-4-yl)- 1H-imidazol-4- yl)propan-2-ol;
59
2-(1-(2-isopropyl-6- methylphenyl)-2-(3- methyl-3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
60
2-(2-(3′-(ethylsulfonyl)- 3-methylbiphenyl-4-yl)- 1-(2-isopropyl-6- methylphenyl)-1H- imidazol-4-yl)propan-2-ol;
61
2-(1-(2- isopropylphenyl)-2-(3- methyl-3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
62
2-(2-(3′-(ethylsulfonyl)- 3-methylbiphenyl-4-yl)- 1-(2-isopropylphenyl)- 1H-imidazol-4- yl)propan-2-ol;
63
2-(1-(2,6- dichlorophenyl)-2-(3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
64
2-(1-(2,6- dichlorophenyl)-2-(3′- (ethylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
65
2-(2-(3-chloro-3′- (methylsulfonyl)biphenyl- 4-yl)-1-(2,6- dichlorophenyl)-1H- imidazol-4-yl)propan-2-ol;
66
2-(2-(3-chloro-3′- (ethylsulfonyl)biphenyl- 4-yl)-1-(2,6- dichlorophenyl)-1H- imidazol-4-yl)propan-2-ol;
67
1,1,1-trifluoro-2-(1-(3′- (methylsulfonyl)biphenyl- 4-yl)-2-(2- (trifluoromethyl)phenyl)- 1H-imidazol-4- yl)propan-2-ol;
68
ethyl 1-(3-chloro-3′- (methylsulfonyl)biphenyl- 4-yl)-2-(2,6- dichlorophenyl)-1H- imidazole-4-carboxylate;
72
3-(2-(2,3- dichlorophenyl)-1-(3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)pentan-3-ol;
73
3-(2-(2,3- dichlorophenyl)-1-(3′- (ethylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)pentan-3-ol;
74
3-(2-(2,6- dichlorophenyl)-1-(3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)pentan-3-ol;
80
N-benzyl-3′-chloro-4′- (2-(2-chloro-6- fluorophenyl)-4-(2- hydroxypropan-2-yl)- 1H-imidazol-1-yl)-3- (methylsulfonyl)biphenyl- 4-carboxamide;
81
3′-chloro-4′-(2-(2- chloro-6-fluorophenyl)- 4-(2-hydroxypropan-2- yl)-1H-imidazol-1-yl)- N-ethyl-3- (methylsulfonyl)biphenyl- 4-carboxamide;
82
2-(2,6-dichlorophenyl)- N-ethyl-1-(3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazole- 4-carboxamide;
83
(2-(2,6- dichlorophenyl)-1-(3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)(4-methylpiperazin- 1-yl)methanone;
84
2-(2,6-dichlorophenyl)- N-(2-hydroxyethyl)-1-(3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazole- 4-carboxamide;
85
2-(2,6-dichlorophenyl)- 1-(3-methyl-3′- (methylsulfonyl)biphenyl- 4-yl)-N-(2,2,2- trifluoroethyl)-1H- imidazole-4- carboxamide;
86
2-(2,6-dichlorophenyl)- N,N-diethyl-1-(3- methyl-3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazole- 4-carboxamide
87
2-(2,6-dichlorophenyl)- 1-(3′- (methylsulfonyl)biphenyl- 4-yl)-N-(2,2,2- trifluoroethyl)-1H- imidazole-4- carboxamide;
88
2-(2,6-dichlorophenyl)- N-(2-fluoroethyl)-1-(3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazole- 4-carboxamide;
89
2-(2-isopropylphenyl)- 1-(3-methyl-3′- (methylsulfonyl)biphenyl- 4-yl)-N-(2,2,2- trifluoroethyl)-1H- imidazole-4-carboxamide;
90
2-(2-(2- (dimethylamino)-6- fluorophenyl)-1-(3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
91
2-(2-(2,6- dichlorophenyl)-1-(3′- (ethylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
92
2-(2-(2-chloro-6- fluorophenyl)-1-(3′- (ethylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
93
2-(2-(2-ethylphenyl)-1-(3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
94
2-(2-(2- isopropylphenyl)-1-(3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
95
2-(2-(2-chloro-3- fluorophenyl)-1-(3′- (ethylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
96
2-(1-(3′- (ethylsulfonyl)biphenyl- 4-yl)-2-(2- isopropylphenyl)-1H- imidazol-4-yl)propan-2-ol;
97
2-(2-(2-chloro-6- methylphenyl)-1-(3′- (ethylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
98
2-(2-(2,3- dichlorophenyl)-1-(4′- (hydroxymethyl)-3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
99
2-(2-(2,6- dichlorophenyl)-1-(4′- (hydroxymethyl)-3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
100
2-(2-(2-chloro-6- fluorophenyl)-1-(4′- (hydroxymethyl)-3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
101
2-(2-(3-chloro-2- methylphenyl)-1-(4′- (hydroxymethyl)-3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
102
2-(2-(2-chloro-6- methylphenyl)-1-(4′- (hydroxymethyl)-3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
103
2-(2-(2,6- difluorophenyl)-1-(4′- (hydroxymethyl)-3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
104
2-(2,6-dichlorophenyl)- 1-(3′-(ethylsulfonyl)-3- methylbiphenyl-4-yl)- N-(2,2,2-trifluoroethyl)- 1H-imidazole-4- carboxamide;
105
2-(2-(2,3- dichlorophenyl)-1-(4′- (2-hydroxypropan-2-yl)-3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
106
2-(2-(2,6- dichlorophenyl)-1-(3′- methyl-5′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
107
2-(1-(2′-chloro-5′- (methylsulfonyl)biphenyl- 4-yl)-2-(2,6- dichlorophenyl)-1H- imidazol-4-yl)propan-2-ol;
108
4′-(2-(2,6- dichlorophenyl)-4-(2- hydroxypropan-2-yl)- 1H-imidazol-1-yl)-N- methylbiphenyl-3- sulfonamide;
109
2-(1-(3-fluoro-3′- (methylsulfonyl)biphenyl- 4-yl)-2-(2- (trifluoromethyl)phenyl)- 1H-imidazol-4- yl)propan-2-ol;
110
2-(1-(3′-(ethylsulfonyl)- 3-fluorobiphenyl-4-yl)- 2-(2- (trifluoromethyl)phenyl)- 1H-imidazol-4- yl)propan-2-ol;
111
2-(1-(2-fluoro-3′- (methylsulfonyl)biphenyl- 4-yl)-2-(2- (trifluoromethyl)phenyl)- 1H-imidazol-4- yl)propan-2-ol;
112
2-(1-(3′-(ethylsulfonyl)- 2-fluorobiphenyl-4-yl)- 2-(2- (trifluoromethyl)phenyl)- 1H-imidazol-4- yl)propan-2-ol;
113
2-(2-(2,3- dichlorophenyl)-1-(3- fluoro-3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
114
2-(2-(2,3- dichlorophenyl)-1-(3′- (ethylsulfonyl)-3- fluorobiphenyl-4-yl)- 1H-imidazol-4- yl)propan-2-ol;
115
2-(2-(2,6- dichlorophenyl)-1-(3- fluoro-3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
116
2-(2-(2,6- dichlorophenyl)-1-(3′- (ethylsulfonyl)-3- fluorobiphenyl-4-yl)- 1H-imidazol-4- yl)propan-2-ol;
117
2-(2-(2,3- dichlorophenyl)-1-(3- fluoro-4′- (hydroxymethyl)-3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
118
2-(2-(3-chloro-2- methylphenyl)-1-(3- fluoro-3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
119
2-(2-(3-chloro-2- methylphenyl)-1-(3′- (ethylsulfonyl)-3- fluorobiphenyl-4-yl)- 1H-imidazol-4- yl)propan-2-ol;
120
2-(2-(3-chloro-2- methylphenyl)-1-(3- fluoro-4′- (hydroxymethyl)-3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
121
2-(1-(3-fluoro-4′- (hydroxymethyl)-3′- (methylsulfonyl)biphenyl- 4-yl)-2-(2- (trifluoromethyl)phenyl)- 1H-imidazol-4- yl)propan-2-ol;
122
2-(2-(2,6- dichlorophenyl)-1-(3- fluoro-4′- (hydroxymethyl)-3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
123
2-(2-(2-chloro-3- fluorophenyl)-1-(3- fluoro-3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
124
2-(2-(2-chloro-3- fluorophenyl)-1-(3′- (ethylsulfonyl)-3- fluorobiphenyl-4-yl)- 1H-imidazol-4- yl)propan-2-ol;
125
2-(2-(2-chloro-3- fluorophenyl)-1-(3- fluoro-4′- (hydroxymethyl)-3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
126
2-(2-(2-chloro-6- fluorophenyl)-1-(3′- (ethylsulfonyl)-3- fluorobiphenyl-4-yl)- 1H-imidazol-4- yl)propan-2-ol;
127
2-(2-(2-chloro-6- fluorophenyl)-1-(3- fluoro-4′- (hydroxymethyl)-3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
128
2-(2-(2-chloro-6- methylphenyl)-1-(3- fluoro-3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
129
2-(2-(2-chloro-6- methylphenyl)-1-(3′- (ethylsulfonyl)-3- fluorobiphenyl-4-yl)- 1H-imidazol-4- yl)propan-2-ol;
130
2-(2-(2,6- difluorophenyl)-1-(3- fluoro-3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
131
2-(2-(2,6- difluorophenyl)-1-(3′- (ethylsulfonyl)-3- fluorobiphenyl-4-yl)- 1H-imidazol-4- yl)propan-2-ol;
132
2-(2-(2,6- difluorophenyl)-1-(3′- (ethylsulfonyl)-3- fluorobiphenyl-4-yl)- 1H-imidazol-4- yl)propan-2-ol;
133
2-(2-(2-chloro-6- methylphenyl)-1-(3- fluoro-4′- (hydroxymethyl)-3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
134
2-(2-(2-chloro-6- fluorophenyl)-1-(3- fluoro-3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
135
2-(1-(3-chloro-3′- (methylsulfonyl)biphenyl- 4-yl)-2-(2- (trifluoromethyl)phenyl)- 1H-imidazol-4- yl)propan-2-ol;
136
2-(1-(3-chloro-3′- (ethylsulfonyl)biphenyl- 4-yl)-2-(2- (trifluoromethyl)phenyl)- 1H-imidazol-4- yl)propan-2-ol;
137
2-(1-(3-chloro-3′- (ethylsulfonyl)biphenyl- 4-yl)-2-(2- chlorophenyl)-1H- imidazol-4-yl)propan-2-ol;
138
2-(1-(3-chloro-4′- (hydroxymethyl)-3′- (methylsulfonyl)biphenyl- 4-yl)-2-(2- chlorophenyl)-1H- imidazol-4-yl)propan-2-ol;
139
2-(1-(3-chloro-4′- (hydroxymethyl)-3′- (methylsulfonyl)biphenyl- 4-yl)-2-(2- (trifluoromethyl)phenyl)- 1H-imidazol-4- yl)propan-2-ol;
140
2-(1-(3-chloro-3′- (methylsulfonyl)biphenyl- 4-yl)-2-(2,3- dichlorophenyl)-1H- imidazol-4-yl)propan-2-ol;
141
2-(1-(3-chloro-3′- (ethylsulfonyl)biphenyl- 4-yl)-2-(2,3- dichlorophenyl)-1H- imidazol-4-yl)propan-2-ol;
142
2-(1-(3-chloro-3′- (methylsulfonyl)biphenyl- 4-yl)-2-(2,6- dichlorophenyl)-1H- imidazol-4-yl)propan-2-ol;
143
2-(2-(3-chloro-2- methylphenyl)-1-(3- chloro-3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
144
2-(2-(3-chloro-2- methylphenyl)-1-(3- chloro-3′- (ethylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
145
2-(1-(3-chloro-3′- (methylsulfonyl)biphenyl- 4-yl)-2-(2-chloro-6- fluorophenyl)-1H- imidazol-4-yl)propan-2-ol;
146
2-(1-(3-chloro-3′- (ethylsulfonyl)biphenyl- 4-yl)-2-(2-chloro-6- fluorophenyl)-1H- imidazol-4-yl)propan-2-ol;
147
2-(1-(3-chloro-4′- (hydroxymethyl)-3′- (methylsulfonyl)biphenyl- 4-yl)-2-(2-chloro-6- fluorophenyl)-1H- imidazol-4-yl)propan-2-ol;
148
2-(1-(3-chloro-4′- (hydroxymethyl)-3′- (methylsulfonyl)biphenyl- 4-yl)-2-(2,3- dichlorophenyl)-1H- imidazol-4-yl)propan-2-ol;
149
2-(1-(3-chloro-4′- (hydroxymethyl)-3′- (methylsulfonyl)biphenyl- 4-yl)-2-(2,6- dichlorophenyl)-1H- imidazol-4-yl)propan-2-ol;
150
2-(1-(3-chloro-3′- (ethylsulfonyl)biphenyl- 4-yl)-2-(2,6- dichlorophenyl)-1H- imidazol-4-yl)propan-2-ol;
151
2-(1-(3-chloro-3′- (methylsulfonyl)biphenyl- 4-yl)-2-(2-chloro-3- fluorophenyl)-1H- imidazol-4-yl)propan-2-ol;
152
2-(1-(3-chloro-3′- (ethylsulfonyl)biphenyl- 4-yl)-2-(2-chloro-3- fluorophenyl)-1H- imidazol-4-yl)propan-2-ol;
153
2-(2-(2-chloro-3- fluorophenyl)-1-(3- chloro-4′- (hydroxymethyl)-3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
154
2-(1-(3-chloro-3′- (ethylsulfonyl)biphenyl- 4-yl)-2-(2-chloro-6- methylphenyl)-1H- imidazol-4-yl)propan-2-ol;
155
2-(1-(3-chloro-4′- (hydroxymethyl)-3′- (methylsulfonyl)biphenyl- 4-yl)-2-(2-chloro-6- methylphenyl)-1H- imidazol-4-yl)propan-2-ol;
156
2-(1-(3-chloro-3′- (methylsulfonyl)biphenyl- 4-yl)-2-(2-chloro-6- methylphenyl)-1H- imidazol-4-yl)propan-2-ol;
157
2-(1-(3-chloro-3′- (methylsulfonyl)biphenyl- 4-yl)-2-(2,6- difluorophenyl)-1H- imidazol-4-yl)propan-2-ol;
158
2-(1-(3-chloro-3′- (ethylsulfonyl)biphenyl- 4-yl)-2-(2,6- difluorophenyl)-1H- imidazol-4-yl)propan-2-ol;
159
2-(1-(3-chloro-4′- (hydroxymethyl)-3′- (methylsulfonyl)biphenyl- 4-yl)-2-(2,6- difluorophenyl)-1H- imidazol-4-yl)propan-2-ol;
160
2-(2-(3-chloro-2- methylphenyl)-1-(3- chloro-4′- (hydroxymethyl)-3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
161
2-(1-(3-chloro-3′- (methylsulfonyl)biphenyl- 4-yl)-2-(2- isopropylphenyl)-1H- imidazol-4-yl)propan-2-ol;
162
2-(3′-chloro-4′-(2-(2- chlorophenyl)-4-(2- hydroxypropan-2-yl)- 1H-imidazol-1-yl)-3- (methylsulfonyl)biphenyl- 4-yl)propan-2-ol;
163
2-(1-(3-chloro-4′-(2- hydroxypropan-2-yl)-3′- (methylsulfonyl)biphenyl- 4-yl)-2-(2- (trifluoromethyl)phenyl)- 1H-imidazol-4- yl)propan-2-ol;
164
2-(3′-chloro-4′-(2-(2- chloro-6-fluorophenyl)- 4-(2-hydroxypropan-2- yl)-1H-imidazol-1-yl)-3- (methylsulfonyl)biphenyl- 4-yl)propan-2-ol;
165
ethyl 3′-chloro-4′-(2-(2- chloro-6-fluorophenyl)- 4-(2-hydroxypropan-2- yl)-1H-imidazol-1-yl-3- (methylsulfonyl)biphenyl- 4-carboxylate;
166
(3′-chloro-4′-(2-(2- chloro-6-fluorophenyl)- 4-(2-hydroxypropan-2- yl)-1H-imidazol-1-yl)-3- (methylsulfonyl)biphenyl-4- yl)(morpholino)methanone;
167
3′-chloro-4′-(2-(2- chloro-6-fluorophenyl)- 4-(2-hydroxypropan-2- yl)-1H-imidazol-1-yl)- N,N-dimethyl-3- (methylsulfonyl)biphenyl- 4-carboxamide;
168
2-(1-(3-chloro-5- methyl-3′- (methylsulfonyl)biphenyl- 4-yl)-2-(2- chlorophenyl)-1H- imidazol-4-yl)propan-2-ol;
169
2-(1-(3-chloro-3′- (ethylsulfonyl)-5- methylbiphenyl-4-yl)-2- (2-chlorophenyl)-1H- imidazol-4-yl)propan-2-ol;
170
2-(2-(2-chlorophenyl)- 1-(3-ethyl-3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
171
2-(1-(4′- (hydroxymethyl)-3- methyl-3′- (methylsulfonyl)biphenyl- 4-yl)-2-(2- (trifluoromethyl)phenyl)- 1H-imidazol-4- yl)propan-2-ol;
172
2-(2-(2-chloro-6- fluorophenyl)-1-(4′- (hydroxymethyl)-3- methyl-3′- methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
173
2-(2-(2-chloro-3- fluorophenyl)-1-(4′- (hydroxymethyl)-3- methyl-3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
174
2-(2-(2,6- dichlorophenyl)-1-(4′- (hydroxymethyl)-3- methyl-3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
175
2-(2-(3-chloro-2- methylphenyl)-1-(4′- (hydroxymethyl)-3- methyl-3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
176
2-(2-(2,3- dichlorophenyl)-1-(4′- (hydroxymethyl)-3- methyl-3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
177
2-(2-(2-chloro-6- methylphenyl)-1-(4′- (hydroxymethyl)-3- methyl-3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
178
2-(2-(2,6- difluorophenyl)-1-(4′- (hydroxymethyl)-3- methyl-3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
179
2-(2-(2,3- dichlorophenyl)-1-(3- methyl-3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
180
2-(2-(2,3- dichlorophenyl)-1-(3′- (ethylsulfonyl)-3- methylbiphenyl-4-yl)- 1H-imidazol-4- yl)propan-2-ol;
181
2-(2-(2,6- dichlorophenyl)-1-(3- methyl-3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
182
2-(2-(2,6- dichlorophenyl)-1-(3′- (ethylsulfonyl)-3- methylbiphenyl-4-yl)- 1H-imidazol-4- yl)propan-2-ol;
183
2-(1-(3-methyl-3′- (methylsulfonyl)biphenyl- 4-yl)-2-(2- (trifluoromethyl)phenyl)- 1H-imidazol-4- yl)propan-2-ol;
184
2-(1-(3′-(ethylsulfonyl)- 3-methylbiphenyl-4-yl)-2-(2- (trifluoromethyl)phenyl)- 1H-imidazol-4- yl)propan-2-ol;
185
2-(2-(2-chloro-3- fluorophenyl)-1-(3- methyl-3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
186
2-(2-(2-chloro-3- fluorophenyl)-1-(3′- (ethylsulfonyl)-3- methylbiphenyl-4-yl)- 1H-imidazol-4- yl)propan-2-ol;
187
2-(2-(2-chloro-6- fluorophenyl)-1-(3- methyl-3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
188
2-(2-(2-chloro-6- fluorophenyl)-1-(3′- (ethylsulfonyl)-3- methylbiphenyl-4-yl)- 1H-imidazol-4- yl)propan-2-ol;
189
2-(2-(3-chloro-2- methylphenyl)-1-(3- methyl-3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
190
2-(2-(3-chloro-2- methylphenyl)-1-(3′- (ethylsulfonyl)-3- methylbiphenyl-4-yl)- 1H-imidazol-4- yl)propan-2-ol;
191
2-(2-(2-chloro-6- methylphenyl)-1-(3- methyl-3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
192
2-(2-(2-chloro-6- methylphenyl)-1-(3′- (ethylsulfonyl)-3- methylbiphenyl-4-yl)- 1H-imidazol-4- yl)propan-2-ol;
193
2-(2-(2,6- difluorophenyl)-1-(3- methyl-3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
194
2-(2-(2,6- difluorophenyl)-1-(3′- (ethylsulfonyl)-3- methylbiphenyl-4-yl)- 1H-imidazol-4- yl)propan-2-ol;
195
2-(2-(2- isopropylphenyl)-1-(3- methyl-3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
196
2-(1-(3′-(ethylsulfonyl)- 3-methylbiphenyl-4-yl)- 2-(2-isopropylphenyl)- 1H-imidazol-4- yl)propan-2-ol;
197
2-(1-(2,6- dichlorophenyl)-2-(3- methyl-3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
198
2-{1-[3′- (methylsulfonyl)biphenyl- 4-yl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
199
2-{1-[4′- (methylsulfonyl)biphenyl- 4-yl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
200
2-{1-[3′- (ethylsulfonyl)biphenyl- 4-yl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
201
2-{1-[3′- (methylsulfonyl)biphenyl- 3-yl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
202
2-{1-[2′- (trifluoromethyl)biphenyl- 4-yl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
203
2-{1-(2′,3′- difluorobiphenyl-4-yl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
204
2-(1-{4′-[(1- methylethyl)oxy]biphenyl- 4-yl}-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl)propan-2-ol;
205
2-{1-(4′-fluoro-3′- methylbiphenyl-4-yl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
206
2-{1-(3′-fluorobiphenyl- 4-yl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
207
2-{1-(2′,4′,5′- trifluorobiphenyl-4-yl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
208
2-{1-[5′-fluoro-2′- (methyloxy)biphenyl-4- yl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
209
2-{1-(4′- chlorobiphenyl-4-yl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
210
2-{1-(4-pyrimidin-5- ylphenyl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
211
2-{1-[4′- (hydroxymethyl)biphenyl- 4-yl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
212
2-{1-[4′- (dimethylamino)biphenyl- 4-yl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
213
2-{1-[4′- (trifluoromethyl)biphenyl- 4-yl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
214
2-{1-[4′-(1- methylethyl)biphenyl- 4-yl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
215
2-{1-[4′-chloro-2′- (trifluoromethyl)biphenyl- 4-yl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
216
2-{1-(2′,3′,4′- trifluorobiphenyl-4-yl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
217
2-{1-(3′,4′- difluorobiphenyl-4-yl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
218
2-{1-(2′-chloro-6′- fluoro-3′- methylbiphenyl-4-yl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
219
2-{1-[5′-chloro-2′- (methyloxy)biphenyl-4- yl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
220
2-{1-[2′-fluoro-5′- (trifluoromethyl)biphenyl- 4-yl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
221
2-{1-[2′- (methylthio)biphenyl-4- yl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
222
4′-{4-(1-hydroxy-1- methylethyl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-1- yl}biphenyl-4- carboxylic acid;
223
2-{1-[4-(1,3- benzodioxol-5- yl)phenyl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
224
2-(1-{4-[6- (methyloxy)pyridin-3- yl]phenyl}-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl)propan-2-ol;
226
2-{1-(3′- chlorobiphenyl-4-yl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
227
2-{1-[2′-fluoro-5′- (methyloxy)biphenyl-4- yl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
228
ethyl 4′-{4-(1-hydroxy- 1-methylethyl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-1- yl}biphenyl-4- carboxylate;
229
2-{1-(4-{2-[(1- methylethyl)oxy]pyridin- 3-yl}phenyl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
230
2-{1-[3′-chloro-4′- (methyloxy)biphenyl-4- yl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
232
2-{1-[2′-fluoro-3′- (methyloxy)biphenyl-4- yl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
233
4′-{4-(1-hydroxy-1- methylethyl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-1- yl}biphenyl-3- carboxamide;
234
4′-{4-(1-hydroxy-1- methylethyl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-1 yl}biphenyl-4- carboxamide;
235
2-(1-{4′- [(trifluoromethyl)oxy]bi- phenyl-4-yl}-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl)propan-2-ol;
236
2-{1-[4′-fluoro-3′- (trifluoromethyl)biphenyl- 4-yl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
237
2-{1-(4′- propylbiphenyl-4-yl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
238
2-{1-[4′-(ethyloxy)-3′- (trifluoromethyl)biphenyl- 4-yl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
239
2-(1-{2′-[(1- methylethyl)oxy]biphenyl- 4-yl}-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl)propan-2-ol;
240
2-(1-{3′-chloro-4′-[(1- methylethyl)oxy]biphenyl- 4-yl}-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl)propan-2-ol;
241
2-{1-[4-(1H-indol-4- yl)phenyl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
242
2-{1-[4′- (methylthio)biphenyl-4- yl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
243
2-{1-[3′- (hydroxymethyl)biphenyl- 4-yl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
244
2-{1-[3′- (ethyloxy)biphenyl-4- yl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
245
2-{1-(4′-ethylbiphenyl- 4-yl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
246
2-{1-(2′,4′- difluorobiphenyl-4-yl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
247
2-{1-(3′,4′- dichlorobiphenyl-4-yl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
248
2-{1-[2′-chloro-4′- (trifluoromethyl)biphenyl- 4-yl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
249
2-{1-(4-naphthalen-2- ylphenyl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
250
2-{1-[3′- (methyloxy)biphenyl-4- yl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol
251
4′-{4-(1-hydroxy-1- methylethyl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-1- yl}biphenyl-3-ol;
252
2-{1-(3′,4′,5′- trifluorobiphenyl-4-yl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
253
1-[5-(4-{4-(1-hydroxy- 1-methylethyl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-1- yl}phenyl)-2- thienyl]ethanone;
254
2-{1-(3′,5′- difluorobiphenyl-4-yl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
255
2-{1-(3′-chloro-4′- fluorobiphenyl-4-yl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
256
2-{1-[5′-methyl-2′- (methyloxy)biphenyl-4- yl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
257
2-{1-(2′,5′- difluorobiphenyl-4-yl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
258
2-{1-[3′- (butyloxy)biphenyl-4- yl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
259
2-{1-[5′-chloro-2′- (ethyloxy)biphenyl-4- yl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
260
2-(1-{3′- [(trifluoromethyl)oxy]bi- phenyl-4-yl}-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl)propan-2-ol;
261
2-{1-(2′,3′,5′- trifluorobiphenyl-4-yl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
262
2-{1-[3′- (ethylthio)biphenyl-4- yl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
263
2-(1-{3′-[(1- methylethyl)oxy]biphenyl- 4-yl}-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl)propan-2-ol;
264
2-{1-[4-(1-benzothien- 3-yl)phenyl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
265
2-{1-[4-(4- methylnaphthalen-1- yl)phenyl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
266
2-{1-(2′,4′- dichlorobiphenyl-4-yl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
267
2-{1-[3′,4′- bis(methyloxy)biphenyl- 4-yl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
268
2-{2-[2- (trifluoromethyl)phenyl]- 1-(2′,4′,5′- trimethylbiphenyl-4- yl)-1H-imidazol-4- yl}propan-2-ol;
269
4-fluoro-4′-{4-(1- hydroxy-1- methylethyl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-1- yl}biphenyl-2-ol;
270
2-{1-[2′- (hydroxymethyl)biphenyl- 4-yl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
271
2-{1-[3′- (trifluoromethyl)biphenyl- 4-yl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl]propan-2-ol;
272
2-{1-(2′-chloro-6′- fluorobiphenyl-4-yl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
273
2-{1-[3′,5′-difluoro-2′- (methyloxy)biphenyl-4-yl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
274
2-(1-{4-[2- (methyloxy)pyridin-3- yl]phenyl}-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl)propan-2-ol;
275
2-{1-[2′-methyl-5′- (methyloxy)biphenyl-4- yl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
276
2-{1-(2′-ethylbiphenyl- 4-yl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
277
2-(1-{2′-methyl-4′-[(1- methylethyl)oxy]biphenyl- 4-yl}-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl)propan-2-ol;
278
2-{1-[4′- (ethylsulfonyl)biphenyl- 4-yl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
279
2-{1-(5′-fluoro-2′- methylbiphenyl-4-yl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
280
2-{1-[3′-chloro-4′- (trifluoromethyl)biphenyl- 4-yl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
281
2-{1-(5′-chloro-2′- methylbiphenyl-4-yl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
282
2-{1-[2′-(ethyloxy)-5′- (trifluoromethyl)biphenyl- 4-yl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
283
2-{1-(3′-fluoro-4′- methylbiphenyl-4-yl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
284
methyl (2E)-3-(4′-{4- (1-hydroxy-1- methylethyl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-1- yl}biphenyl-4-yl)prop- 2-enoate;
285
N-ethyl-4′-{4-(1- hydroxy-1- methylethyl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-1- yl}biphenyl-3- carboxamide;
286
2-{1-[4-(2,3-dihydro-1- benzofuran-5- yl)phenyl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
287
2-(1-{3-[6- (methyloxy)pyridin-3- yl]phenyl}-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl)propan-2-ol;
288
3′-{4-(1-hydroxy-1- methylethyl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-1-yl}-N-(1- methylethyl)biphenyl- 3-sulfonamide;
289
3′-{4-(1-hydroxy-1- methylethyl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-1- yl}biphenyl-4- carboxamide;
290
2-(1-{3-[2- (cyclopentyloxy)pyridin- 3-yl]phenyl}-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl)propan-2-ol;
291
2-{1-(3′- chlorobiphenyl-3-yl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
292
2-{1-[2′-fluoro-5′- (methyloxy)biphenyl-3- yl]-2-[2 (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
293
3′-{4-(1-hydroxy-1- methylethyl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-1- yl}biphenyl-3- carboxamide;
294
2-{1-[3′,4′- bis(methyloxy)biphenyl- 3-yl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
295
N-(3′-{4-(1-hydroxy-1- methylethyl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-1- yl}biphenyl-2- yl)methanesulfonamide;
296
2-{1-[3′- (trifluoromethyl)biphenyl- 3-yl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
297
3-fluoro-3′-{4-(1- hydroxy-1- methylethyl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-1- yl}biphenyl-4- carboxylic acid;
298
4-chloro-3′-{4-(1- hydroxy-1- methylethyl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-1- yl}biphenyl-3- carboxamide;
299
2-{1-(3-{2-[(1- methylethyl)oxy]pyridin- 3-yl}phenyl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
300
N-(3′-{4-(1-hydroxy-1- methylethyl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-1- yl}biphenyl-3- yl)acetamide;
301
2-{1-[2′-methyl-5′- (methyloxy)biphenyl-3- yl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
302
N-(3′-{4-(1-hydroxy-1- methylethyl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-1- yl}biphenyl-4- yl)acetamide;
303
2-{1-(4′- chlorobiphenyl-3-yl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
304
2-{1-[4′- (phenyloxy)biphenyl-3- yl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
305
2-{1-[5′-fluoro-2′- (methyloxy)biphenyl-3- yl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
306
2-{1-(2′,3′- dichlorobiphenyl-3-yl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
307
2-(1-{3′- [(trifluoromethyl)oxy]bi- phenyl-3-yl}-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl)propan-2-ol;
308
3′-{4-(1-hydroxy-1- methylethyl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-1- yl}biphenyl-3- sulfonamide;
309
2-{1-[3′,5′- bis(trifluoromethyl)biphenyl- 3-yl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
310
2-{1-(3′,5′- dichlorobiphenyl-3-yl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
311
3-chloro-3′-{4-(1- hydroxy-1- methylethyl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-1-yl}-N- (1-methylethyl)biphenyl- 4-carboxamide;
312
N,N-diethyl-3′-{4-(1- hydroxy-1- methylethyl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-1- yl}biphenyl-3- carboxamide;
313
4-chloro-3′-{4-(1- hydroxy-1- methylethyl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-1-yl}-N-(1- methylethyl)biphenyl- 3-carboxamide;
314
2-{1-[3′- (methyloxy)biphenyl-3- yl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
315
3′-{4-(1-hydroxy-1- methylethyl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-1- yl}biphenyl-3- carboxylic acid;
316
N-ethyl-3′-{4-(1- hydroxy-1- methylethyl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-l- yl}biphenyl-3- carboxamide;
317
4-chloro-N-ethyl-3′-{4- (1-hydroxy-1- methylethyl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-1- yl}biphenyl-3- carboxamide;
318
2-{1-(2′,5′- difluorobiphenyl-3-yl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
319
2-(1-{3′-[(1- methylethyl)oxy]biphenyl- 3-yl}-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl)propan-2-ol;
320
2-{1-[2′-fluoro-5′- (trifluoromethyl)biphenyl- 3-yl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
321
2-{1-(3′,4′- dichlorobiphenyl-3-yl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
322
2-{1-[3′- (ethyloxy)biphenyl-3- yl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
323
2-(1-{2′-methyl-4′-[(1- methylethyl)oxy]biphenyl- 3-yl}-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl)propan-2-ol;
324
2-{1-[3-(1-methyl-1H- indol-5-yl)phenyl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
325
2-{1-[4′-(ethyloxy)-3′- (trifluoromethyl)biphenyl- 3-yl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
326
2-{1-[3′- (ethylsulfonyl)biphenyl- 3-yl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
327
2-{1-[2′- (trifluoromethyl)biphenyl- 3-yl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
328
2-{1-[3′- (hydroxymethyl)biphenyl- 3-yl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
329
2-{1-[3-(1H-indol-4- yl)phenyl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
330
3′-{4-(1-hydroxy-1- methylethyl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-1- yl}biphenyl-4- carboxylic acid;
331
1-[5-(3-{4-(1-hydroxy- 1-methylethyl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-1- yl}phenyl)-2- thienyl]ethanone;
332
2-{1-(5′-chloro-2′- methylbiphenyl-3-yl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
333
2-(1-{4′- [(trifluoromethy)oxy]bi- phenyl-3-yl}-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl)propan-2-ol;
334
2-{1-[2′-chloro-4′- (trifluoromethyl)biphenyl- 3-yl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
335
2-{1-(2′,5′- dichlorobiphenyl-3-yl)- 2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
336
2-{1-[2′-(ethyloxy)-5′- (trifluoromethyl)biphenyl- 3-yl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
337
3′-{4-(1-hydroxy-1- methylethyl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-1-yl}-N-(1- methylethyl)biphenyl- 4-carboxamide;
338
2-{1-(2′,4′- dichlorobiphenyl-3-yl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
339
2-{1-[4- (ethylsulfonyl)biphenyl- 3-yl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
340
2-{1-[4′-fluoro-3′- (trifluoromethyl)biphenyl- 3-yl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
341
2-{1-(3′-fluoro-4′- methylbiphenyl-3-yl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
342
N-butyl-4′-{4-(1- hydroxy-1- methylethyl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-1- yl}biphenyl-3- sulfonamide;
343
N-(1,1-dimethylethyl)- 4′-{4-(1-hydroxy-1- methylethyl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-1-yl}-6- methylbiphenyl-3- sulfonamide;
344
4′-{4-(1-hydroxy-1- methylethyl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-1-yl}-N- methylbiphenyl-3- sulfonamide;
345
N-ethyl-4′-{4-(1- hydroxy-1- methylethyl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-1- yl}biphenyl-3- sulfonamide;
346
N-(1,1-dimethylethyl)- 4′-{4-(1-hydroxy-1- methylethyl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-1- yl}biphenyl-3- sulfonamide;
347
2-{1-[2′-amino-5′- (trifluoromethyl)biphenyl- 4-yl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
348
2-{1-[3′-fluoro-5′- (trifluoromethyl)biphenyl- 4-yl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
349
2-{1-[4′-chloro-3′- (trifluoromethyl)biphenyl- 4-yl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
350
3-chloro-4′-{4-(1- hydroxy-1- methylethyl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-1- yl}biphenyl-4- carboxylic acid;
351
2-(2-[2- (trifluoromethyl)phenyl]-1-{3′- [(trifluoromethyl)thio]bi- phenyl-4-yl}-1H- imidazol-4-yl)propan-2-ol;
352
2-{1-[3′-(morpholin-4- ylsulfonyl)biphenyl-4- yl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
353
2-(1-{4-[5- (hydroxymethyl)-1,3- thiazol-2-yl]phenyl}-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl)propan-2-ol;
354
2-{1-[2′-methyl-5′- (piperidin-1- ylsulfonyl)biphenyl-4- yl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
355
1-[4-(4-{4-(1-hydroxy- 1-methylethyl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-1 yl}phenyl)-2- thienyl]ethanone;
356
2-(1-{4-[5- (hydroxymethyl)-3- thienyl]phenyl}-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl)propan-2-ol;
357
4-(2-chlorophenyl)-5- {5-[3- (methylsulfonyl)phenyl]- 2-thienyl}-2- (trifluoromethyl)-1H- imidazole;
358
2-(2-chlorophenyl)-1-[3′- (methylsulfonyl)biphenyl- 4-yl]-4- (trifluoromethyl)-1H- imidazole;
359
4-(2-chlorophenyl)-5-[3′- (methylsulfonyl)biphenyl- 4-yl]-2- (trifluoromethyl)-1H- imidazole;
360
4′-[2-(2-chlorophenyl)- 4-(trifluoromethyl)-1H- imidazol-1-yl]biphenyl- 3-sulfonamide;
361
4′-[4-(2-chlorophenyl)- 2-(trifluoromethyl)-1H- imidazol-5-yl]biphenyl- 3-sulfonamide;
362
3-{5-[4-(2- chlorophenyl)-2- (trifluoromethyl)-1H- imidazol-5-yl]-2- thienyl}benzenesulfonamide;
364
1-[3′- (methylsulfonyl)biphenyl- 4-yl]-4- (trifluoromethyl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazole;
365
4′-{4-(trifluoromethyl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-1- yl}biphenyl-3-sulfonamide;
367
ethyl 1-[3′- (methylsulfonyl)biphenyl- 4-yl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazole-4- carboxylate;
369
5-[3- (methylsulfonyl)phenyl]-2-{4- (trifluoromethyl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-1- yl}pyridine;
370
2-[2-(2-chlorophenyl)- 4-(trifluoromethyl)-1H- imidazol-l-yl]-5-[3- (methylsulfonyl)phen- yl]pyridine;
371
2-{1-[3′- (methylsulfonyl)biphenyl- 4-yl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
372
5-{3-[(1- methylethyl)sulfonyl]phenyl}- 2-{4-(trifluoromethyl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-1- yl}pyridine;
373
1-{3′-[(1- methylethyl)sulfonyl]bi- phenyl-4-yl}-4- (trifluoromethyl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazole;
375
N-(4′-{4- (trifluoromethyl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-1- yl}biphenyl-3- yl)methanesulfonamide;
376
ethyl 1-[3′- (methylsulfonyl)biphenyl- 4-yl]-2-phenyl-1H- imidazole-4-carboxylate;
378
2-{1-[3′- (methylsulfonyl)biphenyl- 4-yl]-2-phenyl-1H- imidazol-4-yl}propan-2-ol;
379
2-{2-(2-chlorophenyl)-1-[3′- (methylsulfonyl)biphenyl- 4-yl]-1H-imidazol-4- yl}propan-2-ol;
380
2-{2-(2-fluorophenyl)-1-[3′- (methylsulfonyl)biphenyl- 4-yl]-1H-imidazol-4- yl}propan-2-ol;
382
2-{2-(2,3- dichlorophenyl)-1-[3′- (methylsulfonyl)biphenyl- 4-yl]-1H-imidazol-4- yl}propan-2-ol;
383
2-{2-(2-chloro-3- fluorophenyl)-1-[3′- (methylsulfonyl)biphenyl- 4-yl]-1H-imidazol-4- yl}propan-2-ol;
384
4′-[2-(2-chlorophenyl)- 4-(1-hydroxy-1- methylethyl)-1H- imidazol-l-yl]biphenyl- 3-sulfonamide;
385
2-{2-(4-fluorophenyl)-1-[3′- (methylsulfony)biphenyl- 4-yl]-1H-imidazol-4- yl}propan-2-ol;
386
2-{2-(2-chlorophenyl)- 1-[3-fluoro-3′- (methylsulfonyl)biphenyl- 4-yl]-1H-imidazol-4- yl}propan-2-ol;
387
2-{2-(2-chlorophenyl)- 1-[2-fluoro-3′- (methylsulfonyl)biphenyl- 4-yl]-1H-imidazol-4- yl}propan-2-ol;
388
2-{2-(2-chlorophenyl)- 1-[3′-(1- methylethyl)biphenyl- 4-yl]-1H-imidazol-4- yl}propan-2-ol;
389
2-{2-(2-chlorophenyl)- 1-[4′-(1,1- dimethylethyl)biphenyl- 4-yl]-1H-imidazol-4- yl}propan-2-ol;
390
methyl 4′-[2-(2- chlorophenyl)-4-(1- hydroxy-1- methylethyl)-1H- imidazol-1-yl]biphenyl- 3-carboxylate;
391
N-{4′-[2-(2- chlorophenyl)-4-(1- hydroxy-1- methylethyl)-1H- imidazol-1-yl]biphenyl- 3-yl}-1,3- benzodioxole-5- carboxamide;
392
2-{1-[3′- (methylsulfonyl)biphenyl- 4-yl]-2-[3- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
393
2-{2-(3-chlorophenyl)-1-[3′- (methylsulfonyl)biphenyl- 4-yl]-1H-imidazol-4- yl}propan-2-ol;
394
2-{2-(2-chloro-6- methylphenyl)-1-[3′- (methylsulfonyl)biphenyl- 4-yl]-1H-imidazol-4- yl}propan-2-ol;
395
4′-[2-(2-chlorophenyl)- 4-(1-hydroxy-1- methylethyl)-1H- imidazol-1-yl]biphenyl- 3-carboxylic acid;
397
2-(2-chlorophenyl)-1-[3′- (methylsulfonyl)biphenyl- 4-yl]-N-(2,2,2- trifluoroethyl)-1H- imidazole-4- carboxamide;
399
2-{1-[4′-(methyloxy)-3′- (methylsulfonyl)biphenyl- 4-yl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
400
2-{1-[4′- (hydroxymethyl)-3′- (methylsulfonyl)biphenyl- 4-yl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
401
ethyl 4′-{4-(1-hydroxy- 1-methylethyl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-1-yl}-5- (methylsulfonyl)biphenyl- 3-carboxylate;
402
2-{5-bromo-1-[3′- (methylsulfonyl)biphenyl- 4-yl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
403
2-{5-chloro-1-[3′- (methylsulfonyl)biphenyl- 4-yl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
404
2-{1-[4′- (methylsulfonyl)biphenyl- 4-yl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
405
2-[1-(3′-aminobiphenyl- 4-yl)-2-(2- chlorophenyl)-1H- imidazol-4-yl]propan-2-ol;
406
2-{5-fluoro-1-[3′- (methylsulfonyl)biphenyl- 4-yl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
407
2-{1-[4′- (methylsulfonyl)biphenyl- 3-yl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
409
2-{2-(2-chlorophenyl)- 1-[3′-(1-hydroxy-1- methylethyl)biphenyl- 4-yl]-1H-imidazol-4- yl}propan-2-ol;
410
2-{2-(2,6- difluorophenyl)-1-[3′- (methylsulfonyl)biphenyl- 4-yl]-1H-imidazol-4- yl}propan-2-ol;
413
2-(1-{3-[(1- methylethyl)sulfonyl]bi- phenyl-4-yl}-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl)propan-2-ol;
414
2-(1-{3′-[(1- methylethyl)sulfonyl]bi- phenyl-3-yl}-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl)propan-2-ol;
415
2-{2-(2-chlorophenyl)-1-[3′- (ethylsulfonyl)biphenyl- 4-yl]-1H-imidazol-4- yl}propan-2-ol;
416
2-{2-(2-chloro-6- fluorophenyl)-1-[3′- (methylsulfonyl)biphenyl- 4-yl]-1H-imidazol-4- yl}propan-2-ol;
417
2-{1-[3-chloro-3′- (methylsulfonyl)biphenyl- 4-yl]-2-(2- chlorophenyl)-1H- imidazol-4-yl}propan-2-ol;
418
2-{2-(2-chlorophenyl)- 1-[3-methyl-3′- (methylsulfonyl)biphenyl- 4-yl]-1H-imidazol-4- yl}propan-2-ol;
419
2-{2-[2,6- difluorophenyl)-1-[3′- (ethylsulfonyl)biphenyl- 4-yl]-1H-imidazol-4- yl}propan-2-ol;
420
2-(1-{5-[3- (methylsulfonyl)phen- yl]pyridin-2-yl}-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl)propan-2-ol;
421
2-(1-{6-[3- (methylsulfonyl)phen- yl]pyridin-3-yl}-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl)propan-2-ol;
422
2-{2-(2,6- dichlorophenyl)-1-[3′- (methylsulfonyl)biphenyl- 4-yl]-1H-imidazol-4- yl}propan-2-ol;
427
2-{2-(2,3- dichlorophenyl)-1-[3′- (ethylsulfonyl)biphenyl- 4-yl]-1H-imidazol-4- yl}propan-2-ol;
428
2-{5-methyl-1-[3′- (methylsulfonyl)biphenyl- 4-yl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
429
2-{2-(2-chlorophenyl)- 1-[3′-(ethylsulfonyl)-3- fluorobiphenyl-4-yl]- 1H-imidazol-4- yl}propan-2-ol;
430
2-{2-[2-fluoro-6- (trifluoromethyl)phenyl]- 1-[3′-(methylsulfonyl)biphenyl- 4-yl]-1H-imidazol-4- yl}propan-2-ol;
431
2-{2-(2-methylphenyl)- 1-[3′-(methylsulfonyl)biphenyl- 4-yl]-1H-imidazol-4- yl}propan-2-ol;
432
2-(1-[3′- (methylsulfonyl)biphenyl- 4-yl]-2-{2- [(trifluoromethyl)oxy]phen- yl}-1H-imidazol-4- yl)propan-2-ol;
436
2-(1-(2′,5′- dimethylbiphenyl-4-yl- 2-(2-trifluoromethyl)phen- yl)1H-imidazol-4- yl)propan-2-ol;
437
2-{2-(2-chlorophenyl)- 1-[3′-(ethylsulfonyl)-2- fluorobiphenyl-4-yl]- 1H-imidazol-4- yl}propan-2-ol;
438
2-{2-(3-chloro-2- methylphenyl)-1-[3′- (methylsulfonyl)biphenyl- 4-yl]-1H-imidazol-4- yl}propan-2-ol;
439
2-{2-(2-chlorophenyl)- 1-[2-methyl-3′- (methylsulfonyl)biphenyl- 4-yl]-1H-imidazol-4- yl}propan-2-ol;
440
2-{2-(3-chloro-2- methylphenyl)-1-[3′- (ethylsulfonyl)biphenyl- 4-yl]-1H-imidazol-4- yl}propan-2-ol;
443
2-(1-(2-chlorobenzyl)-2-(3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol
444
2-(1-(2,3- dichlorobenzyl)-2-(3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol
445
2-(5-chloro-2-(3- chloro-3′- (methylsulfonyl)biphenyl- 4-yl)-1-(2,6- dichlorophenyl)-1H- imidazol-4-yl)propan-2-ol
446
2-(5-chloro-1-(2,6- dichlorophenyl)-2-(3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol
447
3′-chloro-4′-(2-(2- chloro-6-fluorophenyl)- 4-(2-hydroxypropan-2- yl)-1H-imidazol-1-yl)-3- (methylsulfonyl)biphenyl- 4-carboxylic acid
448
3′-chloro-4′-(2-(2- chloro-6-fluorophenyl)- 4-(2-hydroxypropan-2- yl)-1H-imidazol-1-yl)- N-methoxy-N-methyl-3- (methylsulfonyl)biphenyl- 4-carboxamide
449
2-(2-(2,3- dichlorobenzyl)-1-(3- fluoro-3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol
450
2-(2-(2,3- dichlorobenzyl)-1-(3′- (ethylsulfonyl)-3- fluorobiphenyl-4-yl)- 1H-imidazol-4- yl)propan-2-ol
451
2-(1-(3-chloro-3′- (methylsulfonyl)biphenyl- 4-yl)-2-(2-(2,3- dichlorophenyl)propan- 2-yl)-1H-imidazol-4- yl)propan-2-ol
452
2-(1-(3-chloro-3′- (ethylsulfonyl)biphenyl- 4-yl)-2-(2-(2,3- dichlorophenyl)propan- 2-yl)-1H-imidazol-4- yl)propan-2-ol
453
3′-chloro-4′-(2-(2- chloro-6-fluorophenyl)- 4-(2-hydroxypropan-2- yl)-1H-imidazol-1-yl)-3- (methylsulfonyl)biphenyl- 4-carboxamide
454
2-(1-(3-chloro-4′- methoxy-3′- (methylsulfonyl)biphenyl- 4-yl)-2-(2-chloro-6- fluorophenyl)-1H- imidazol-4-yl)propan-2-ol
455
2-(2-(2,3- dichlorophenyl)-1-(4′- methoxy-3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol
456
2-(2-(2,3- dichlorobenzyl)-1-(4′- methoxy-3-methyl-3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol
457
2-(1-(3-chloro-4′- methoxy-3′- (methylsulfonyl)biphenyl- 4-yl)-2-(2,3- dichlorobenzyl)-1H- imidazol-4-yl)propan-2-ol
458
2-(2-(3-chloro-3′- (methylsulfonyl)biphenyl- 2-yl)-1-(3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol
459
1-(3-chloro-3′- (methylsulfonyl)biphenyl- 4-yl)-2-(2,6- dichlorophenyl)-N- (2,2,2-trifluoroethyl)- 1H-imidazole-4- carboxamide
460
1-(3-chloro-3′- (methylsulfonyl)biphenyl- 4-yl)-2-(2,6- dichlorophenyl)-N-(2- fluoroethyl)-1H- imidazole-4- carboxamide
461
2-(1-(3-chloro-3′- (methylsulfonyl)biphenyl- 4-yl)-2-(2,6- dichlorophenyl)-1H- imidazole-4- carboxamido)acetic acid
462
1-(3-chloro-3′- (ethylsulfonyl)biphenyl- 4-yl)-2-(2,6- dichlorophenyl)-N- (2,2,2-trifluoroethyl)- 1H-imidazole-4- carboxamide
463
1-(3-chloro-3′- (methylsulfonyl)biphenyl- 4-yl)-2-(2,6- dichlorophenyl)-N-(1- hydroxy-2- methylpropan-2-yl)- 1H-imidazole-4-carboxamide
464
1-(3-chloro-3′- (ethylsulfonyl)biphenyl- 4-yl)-2-(2,6- dichlorophenyl)-N-(1- hydroxy-2- methylpropan-2-yl)- 1H-imidazole-4-carboxamide
465
N-tert-butyl-1-(3- chloro-3′- (methylsulfonyl)biphenyl- 4-yl)-2-(2,6- dichlorophenyl)-1H- imidazole-4-carboxamide
466
2-chloro-4′-(2-(2,6- dichlorophenyl)-4-(2- hydroxypropan-2-yl)- 1H-imidazol-1-yl)-3′- methylbiphenyl-4- carboxylic acid
467
2-(1-(2′,3-dichloro-5′- (methylsulfonyl)biphenyl- 4-yl)-2-(2,6- dichlorophenyl)-1H- imidazol-4-yl)propan-2-ol
468
2-(1-(2′-chloro-3- methyl-5′- (methylsulfonyl)biphenyl- 4-yl)-2-(2,3- dichlorobenzyl)-1H- imidazol-4-yl)propan-2-ol
469
6-{3-chloro-4-[2-(2- chloro-6-fluorophenyl)- 4-(1-hydroxy-1- methylethyl)-1H- imidazol-1-yl]phenyl}- 2,3-dihydro-1- benzothiophene-3-ol 1,1-dioxide
470
1-(3-chloro-3′- (methylsulfonyl)biphenyl- 4-yl)-2-(2,6- dichlorophenyl)-N-(2- hydroxyethyl)-1H- imidazole-4- carboxamide
471
1-(3-chloro-3′- (ethylsulfonyl)biphenyl- 4-yl)-2-(2,6- dichlorophenyl)-N-(2- hydroxyethyl)-1H- imidazole-4-carboxamide
472
1-(3-chloro-3′- (methylsulfonyl)biphenyl- 4-yl)-2-(2,6- dichlorophenyl)-N-(2- hydroxy-2- methylpropyl)-1H- imidazole-4- carboxamide
473
1-(3-chloro-3′- (ethylsulfonyl)biphenyl- 4-yl)-2-(2,6- dichlorophenyl)-N-(2- hydroxy-2- methylpropyl)-1H- imidazole-4-carboxamide
474
2-(2-(5-chloro-2- fluorobenzyl)-1-(3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol
475
2-(2-(2,3- dichlorophenyl)-1-(4′- (hydroxymethyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol
476
2-(2-(2,3- dichlorophenyl)-1-(3′- (hydroxymethyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol
477
2-(2-(2,3- dichlorophenyl)-1-(4′- (2-hydroxypropan-2- yl)biphenyl-4-yl)-1H- imidazol-4-yl)propan-2-ol
478
2-(2-(2,3- dichlorophenyl)-1-(3′- (2-hydroxypropan-2- yl)biphenyl-4-yl)-1H- imidazol-4-yl)propan-2-ol
479
2-(2-(2,6- dichlorophenyl)-1-(3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)-2-methylpropan-1-ol
480
1-(3-chloro-3′-(2- hydroxypropan-2- yl)biphenyl-4-yl)-2- (2,6-dichlorophenyl)-N- (1-hydroxy-2- methylpropan-2-yl)- 1H-imidazole-4-carboxamide
481
2-(2,6-dichlorophenyl)- N-(1-hydroxy-2- methylpropan-2-yl)-1-(3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazole- 4-carboxamide
482
2-(2-(5-chloro-2- fluorobenzyl)-1-(3′- (ethylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol
483
2-(2-(3-chloro-2- fluorobenzyl)-1-(3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol
484
2-(1-(3′- (methylsulfonyl)biphenyl- 4-yl)-2-(3- (trifluoromethyl)benzyl)- 1H-imidazol-4- yl)propan-2-ol
485
2-(1-(3′- (ethylsulfonyl)biphenyl- 4-yl)-2-(3- (trifluoromethyl)benzyl)- 1H-imidazol-4- yl)propan-2-ol
486
2-(2,6-dichlorophenyl)-1-(3′- (ethylsulfonyl)biphenyl- 4-yl)-N-(1-hydroxy-2- methylpropan-2-yl)- 1H-imidazole-4- carboxamide, and
487
N-tert-butyl-2-(2,6- dichlorophenyl)-1-(3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazole- 4-carboxamide.

### Claim 25 (depends on 8)

A pharmaceutical composition comprising a compound of claim 8, or a pharmaceutically acceptable salt thereof in a pharmaceutically acceptable carrier.

### Claim 26 (depends on 17)

The compound according to claim 17, of the formula,
or a pharmaceutically acceptable salt thereof.

### Claim 27 (depends on 4)

The compound according to claim 4, wherein R2 is -halogen, —CF3, —CH2OH, or —C(CH3)2OH.

### Claim 28

A compound which is
or a pharmaceutically acceptable salt thereof.

### Claim 29 (depends on 23)

The compound of claim 23, wherein the compound is according to formula IIa.

### Claim 30 (depends on 23)

The compound of claim 23, wherein the compound is according to formula IIb.

### Claim 31 (depends on 28)

A pharmaceutical composition comprising a compound of claim 28, or a pharmaceutically acceptable salt thereof in a pharmaceutically acceptable carrier.