Anti-mitotic anti-proliferative compounds

A method for treating restenosis or a hyperproliferative disorder selected from the group consisting of restenosis, leukemia, lung cancer, colon cancer, central nervous system cancer, ovarian cancer, renal cancer, breast cancer, cervical cancer, prostate cancer, bladder cancer, liver cancer, lymphoma, pancreatic cancer, thyroid cancer, Kaposi's sarcoma, and malignant melanoma, said method comprising administering to a patient in need thereof an anti-mitotic effective amount of the compound of formula (I):

• wherein
• Het is a substituted 1,2,4-triazole;
• Z1Z2, and Z3 are independently a bond or R1—X—R2, wherein X is NR3, O, S, SO, or SO2;
• R1and R2 are independently a bond or substituted or unsubstituted, saturated or unsaturated, straight-chained or branched lower alkylene;
• and R3 is hydrogen, substituted or unsubstituted phenyl, or substituted or unsubstituted, saturated or unsaturated, straight-chained or branched lower alkyl;
• Ar1 is substituted monocyclic aryl;
• Ar2 is substituted or wisubstituted indolyl;
• Ra is hydrogen or a substituted or unsubstituted monocyclic, aryl, or heteroaryl ring system of 5 or 6 ring atoms or a bicyclic aryl or heterotnyl ring system of 8 to 12 ring atoms, wherein each monocyclic ring may contain 0 to 3 heteroatoms, each bicyclic ring may contain 0 to 4 heteroatoms, and each heteroatom is independently selected from the group consisting of N, O, and S;
• and
• the substituents of Ar1, Ar2, and Ra, when substituted, comprise one to three moieties independently selected from the group consisting of alkyl, alkenyl, alkynyl, phenyl, aralkyl, aralkenyl, hydroxy, hydroxyalkyl, alkoxy, alkoxyalkyl, aralkoxy, aryloxy, acyloxy, halo, haloalkyl, nitro, cyano, amino, mono- and dialkylamino, acylamino, carboxy, carboxyalkyl, carbalkoxy, carbaralkoxy, carbalkoxyalkyl, carbalkoxyalkenyl, aminoalkoxy, amido, mono-alkylamido, di-alkylamido, N,N-cycloaLkylamido, sulfonyl, mono-alkyl sulfonyl, di-alkyl sulfonyl, sulthmoyl, monoalkyl sulfamoyl, di-alkyl sulfamoyl, halophenyl, benzoyl, alkylthio and alkylsulfmyl;
• or
• a pharmaceutically acceptable salt thereof.