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US 8,569,343 B2Granted
Oligomer-opioid agonist conjugates
AssigneeNektar Therapeutics
InventorsJennifer Riggs-Sauthier, Bo-Liang Deng, Timothy A. Riley
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Abstract
The invention provides compounds that are chemically modified by covalent attachment of a water-soluble oligomer. A compound of the invention, when administered by any of a number of administration routes, exhibits characteristics that are different from those of the compound not attached to the water-soluble oligomer.
Claims30
A compound selected from a compound of Formula II-Cb
- wherein:
- N* is nitrogen;
- Ar is selected from the group consisting of cyclohexyl, phenyl, halophenyl, methoxyphenyl, aminophenyl, pyridyl, furyl and thienyl;
- Alk is selected from the group consisting of ethylene and propylene;
- RII is selected from the group consisting of lower alkyl, lower alkoxy, dimethylamino, cyclopropyl, 1-pynolidyl, morpholino;
- RII′ is selected from the group consisting of hydrogen, methyl and methoxy;
- RII″ is selected from the group consisting of hydrogen and lower alkyl;
- X is a covalent bond or O;
- and
- POLY is a poly(alkylene oxide) oligomer;
- and pharmaceutically acceptable salts thereof.
8 more elements
A compound selected from a compound of the formula
- wherein n is an integer from 1 to 30;
- and pharmaceutically acceptable salts thereof.
A compound selected from a compound of the formula
- wherein n is an integer from 1 to 30;
- and pharmaceutically acceptable salts thereof.
Dependencies are inferred from the claim text.