Substituted isoquinolin-1(2H)-one compounds, compositions, and methods thereof

A compound of Formula I-1:

• or its pharmaceutically acceptable salt thereof, wherein
• B is a moiety of Formula II:
• wherein Wc is aryl, heteroaryl, heterocycloalkyl, or cycloalkyl, and
• q is an integer of 0, 1, 2, 3, or 4;
• X is absent or —(CH(R9))z—, and z is an integer of 1;
• Y is absent or —N(R9)—;
• Wd is
• Ra′ is hydrogen, halo, phosphate, urea, carbonate, unsubstituted or substituted amino, unsubstituted or substituted alkyl, unsubstituted or substituted alkenyl, unsubstituted or substituted alkynyl, unsubstituted or substituted cycloalkyl, unsubstituted or substituted heteroalkyl, or unsubstituted or substituted heterocycloalkyl;
• R1 is hydrogen, alkyl, alkenyl, alkynyl, alkoxy, amido, alkoxycarbonyl, sulfonamido, halo, cyano, or nitro;
• R2 is alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, heteroarylalkyl, alkoxy, amino, halo, cyano, hydroxy, or nitro;
• R3 is hydrogen, alkyl, or halo;
• each R9 is independently hydrogen, alkyl, or heterocycloalkyl;
• and
• R12 is H, unsubstituted or substituted alkyl, unsubstituted or substituted cyano, unsubstituted or substituted alkynyl, unsubstituted or substituted alkenyl, halo, unsubstituted or substituted aryl, unsubstituted or substituted heteroaryl, unsubstituted or substituted heterocycloalkyl, unsubstituted or substituted cycloalkyl, unsubstituted or substituted amino, carboxylic acid, unsubstituted or substituted alkoxycarbonyl, unsubstituted or substituted amido, unsubstituted or substituted acyl, or unsubstituted or substituted sulfonamido.