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US 8,569,284 B2Granted
Inhibitors of the influenza A virus M2 proton channel
AssigneeThe Trustees of the University of Pennsylvania
InventorsWilliam F. DeGrado, Jun Wang
Life of this patent
Estimating the term…
Abstract
Provided are compounds that are capable of modulating the activity of the influenza A virus via interaction with the M2 transmembrane protein. Also provided are methods for treating an influenza A-affected disease state or infection comprising administering a composition comprising one or more compounds that have been identified as being capable of interaction with the M2 protein.
Claims8
A method for treating an influenza A virus-affected disease state or infection comprising the step of administering to a subject in need thereof a composition comprising a compound of formula (I):
- wherein
- (a)
- X and Y are independently a bond or alkylene;
- R1 is alkyl, hydroxyl, carbonyl, carboxyl, cyano, amino, —CH(R5)(R6), or forms an oxo group together with R2;
- R2 is alkyl, hydroxyl, carbonyl, carboxyl, cyano, amino, or —CH(R5)(R6);
- R3 and R4 are independently hydrogen or —CH(R7)(R8);
- R5 and R6 are independently hydrogen, alkyl, hydroxyl, carbonyl, or amino;
- R7 and R8 are independently hydrogen, alkyl, alkoxy, hydroxyl, carbonyl, or amino;
- dashed lines a and b are optional bonds;
- and,
- n is 0-3,
- or,
- (b)
- X and Y are independently a bond or alkylene;
- R1 is hydrogen, alkyl, hydroxyl, carbonyl, carboxyl, cyano, —CH(R5)(R6), or forms an oxo group together with R2;
- R2 is hydrogen, alkyl, hydroxyl, carbonyl, carboxyl, cyano, or —CH(R5)(R6);
- R3 and R4 are independently hydrogen or —CH(R7)(R8);
- R5 and R6 are independently hydrogen, alkyl, hydroxyl, or carbonyl;
- R7 and R8 are independently hydrogen, alkyl, alkoxy, hydroxyl, or carbonyl;
- dashed lines a and b are optional bonds;
- and,
- n is 0-3,
- or,
- (c)
- X and Y are independently a bond or alkylene;
- R1 is amino, —CH(R5)(R6), or forms an oxo group together with R2;
- R2 is hydrogen, alkyl, hydroxyl, carbonyl, carboxyl, cyano, amino, or —CH(R5)(R6);
- R3 is hydrogen or —CH(R7)(R8);
- R4 is —CH(R7)(R8);
- R5 and R6 are independently hydrogen, alkyl, hydroxyl, carbonyl, or amino;
- R7 and R8 are independently hydrogen, alkyl, alkoxy, hydroxyl, carbonyl, or amino;
- dashed lines a and b are optional bonds;
- and,
- n is 0-3,
- or,
- (d)
- X and Y are independently a bond or alkylene;
- R1 is hydrogen, alkyl, hydroxyl, carbonyl, carboxyl, cyano, amino, —CH(R5)(R6), or forms an oxo group together with R2;
- R2 is hydrogen, alkyl, hydroxyl, carbonyl, carboxyl, cyano, amino, or —CH(R5)(R6);
- R3 and R4 are independently hydrogen or —CH(R7)(R8);
- R5 and R6 are independently hydrogen, alkyl, hydroxyl, carbonyl, or amino;
- R7 and R8 are independently hydrogen, alkyl, alkoxy, hydroxyl, carbonyl, or amino;
- at least one of lines a and b represents a bond;
- and,
- n is 0-3,
- or,
- or a stereoisomer, partial stereoisomer, prodrug, pharmaceutically acceptable salt, hydrate, solvate, acid hydrate, or N-oxide thereof.
44 more elements
Dependencies are inferred from the claim text.