Methods for the treatment of multiple myeloma
AssigneeImmune Disease Institute, Inc.
InventorsUlrich H. von Andrian, Irina Mazo, Jean-Marc Gauguet
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Abstract
Methods for treating multiple myeloma with inhibitors of CXCR4, such as AMD3100 and anti-CXCR4 antibodies, are described. The decreased expression of CXCR4 on multiple myeloma cells according to the invention results in decreased homing of the cells to the bone marrow and a reduction in the development of the disease. Also disclosed are pharmaceutical compositions incorporating such inhibitors for use in the therapeutic treatment of multiple myeloma. The treatment methods described herein can be used independently, or in conjunction with, other therapies for the treatment of multiple myeloma.
Claims9
A method for treating a human subject having, or at risk of having, multiple myeloma comprising administering in vivo to the subject an effective amount of a pharmaceutical composition comprising AMD3100, said method being effective to interrupt the CXCR4/SDF signaling pathway in multiple myeloma cells in the bone marrow of said subject thereby limiting the development of multiple myeloma and increasing the survivability of the subject, said composition being administered for a time period of at least about 6 days, either in daily doses or by continuous infusion.
Dependencies are inferred from the claim text.