# US 8,569,279 B2 · Method for modulating claudin mediated functions

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- Number: US 8,569,279 B2
- Document ID: US8569279B2
- Status: Granted
- Kind: B2
- Application number: 12/853,692
- Filed: 2010-08-10
- Published: 2011-03-03
- Granted: 2013-10-29
- Earliest claimed: 2008-05-27
- Assignees: Sucampo AG; Osaka University
- Applicants: Ryuji Ueno; Sachiko Tsukita
- Inventors: Ryuji Ueno; Sachiko Tsukita
- Web page: https://patentgrep.com/patent/US8569279B2

## CPC

- A61K 31/352: condensed with carbocyclic rings, e.g. methantheline {(cannabinoids A61K31/658)}
- A61K 31/5575: having a cyclopentane, e.g. prostaglandin E2, prostaglandin F2-alpha
- A61K 31/558: having heterocyclic rings containing oxygen as the only ring hetero atom, e.g. thromboxanes
- A61P 17/00: Drugs for dermatological disorders
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

Disclosed is a method for modulating a claudin-mediated function in a mammalian subject which comprises administering to a subject in need thereof an effective amount of a specific fatty acid derivative. The application also discloses a method for treating a dermatological disease and a method for modulating an expression of a claudin in a mammalian subject using the same fatty acid derivative as above.

## Claims

### Claim 1

A method for treating skin ulcer or bed sore in a mammalian subject, which comprises administering to the subject in need thereof an effective amount of a fatty acid derivative which is (−)-7-{(2R,4aR,5R,7aR)-2-[(3S)-1,1-difluoro-3-methyl]pentyl]-2-hydroxy-6-oxooctahydrocyclopenta[b]pyran-5-yl}heptanoic acid or its salt, or ester.

### Claim 2

A method for modulating a claudin-mediated function in a mammalian subject, which comprises administering to the subject in need thereof an effective amount of a fatty acid derivative which is (−)-7-{(2R,4aR,5R,7aR)-2-[(3S)-1,1-difluoro-3-methylpentyl]-2-hydroxy-6-oxooctahydrocyclopenta[b]pyran-5-yl}heptanoic acid or its salt, ester.

### Claim 3 (depends on 2)

The method as described in claim 2, wherein said claudin is claudin-15.

### Claim 4 (depends on 2)

The method as described in claim 2, wherein said claudin-mediated function is epidermal barrier function.

### Claim 5

A method for modulating an expression of a claudin in a mammalian subject, which comprises administering to the subject in need thereof an effective amount of a fatty acid derivative which is (−)-7-{(2R,4aR,5R,7aR)-2-[(3S)-1,1-difluoro-3-methylpentyl]-2-hydroxy-6-oxooctahydrocyclopenta[b]pyran-5-yl}heptanoic acid or its salt, ester.

### Claim 6 (depends on 5)

The method according to claim 5, wherein said claudin is claudin-15.

### Claim 7 (depends on 1)

The method as described in claim 1, wherein said fatty acid derivative is (−)-7-{(2R,4aR,5R,7aR)-2-[(3S)-1,1-difluoro-3-methylpentyl]-2-hydroxy-6-oxooctahydrocyclopenta[b]pyran-5-yl}heptanoic acid.

### Claim 8 (depends on 2)

The method as described in claim 2, wherein said fatty acid derivative is (−)-7-{(2R,4aR,5R,7aR)-2-[(3S)-1,1-difluoro-3-methylpentyl]-2-hydroxy-6-oxooctahydrocyclopenta[b]pyran-5-yl}heptanoic acid.

### Claim 9 (depends on 5)

The method as described in claim 5, wherein said fatty acid derivative is (−)-7-{(2R,4aR,5R,7aR)-2-[(3S)-1,1-difluoro-3-methylpentyl]-2-hydroxy-6-oxooctahydrocyclopenta[b]pyran-5-yl}heptanoic acid.