Steroids having 7-oxgen and 17-heteroaryl substitution

A compound having the structure

• or a salt thereof, wherein the dotted line is an optional double bond;
• R1 is —OH, ═O, —SH, amide, ester or ether;
• R2 is —OH, ═O, halogen, alkyl, ester or ether;
• R3 is —H, —OH, halogen, alkyl, ester or ether;
• R4 is a heterocycle;
• R5 and R6 independently are —H, —CH3, —C2H5, —C3H7, alkyl, —OH, —F, —Cl, —Br or —I;
• R7 is —CH2—, —C(halogen)2—, CH(α-alkyl), —CH(β-alkyl), —CH(α-OH), —CH(β-OH) or —C(alkyl)2;
• R9 is —CH2—, —CH(α-OH), —CH(β-OH) or —C(alkyl)2— or R9 is ═CH— when the optional double bond is present,
• R10A, R10B, R10C and R10D independently are —H, alkyl, —CH3, halogen, —SRPR or —ORPR and each R10A, R10B, R10C and R10D is independently in the α-configuration or the β-configuration;
• and
• RPR independently are —H or a protecting group.