# US 8,569,271 B2 · Compositions comprising tramadol and celecoxib in the treatment of pain

> Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt

- Number: US 8,569,271 B2
- Document ID: US8569271B2
- Status: Granted
- Kind: B2
- Application number: 13/394,995
- Filed: 2010-10-15
- Published: 2012-07-05
- Granted: 2013-10-29
- Earliest claimed: 2009-10-16
- Assignees: Laboratorios Del Dr. Esteve, S.A.
- Applicants: Enrique Portillo Salido; Sebastia Videla Ces
- Inventors: Enrique Portillo Salido; Sebastia Videla Ces
- Web page: https://patentgrep.com/patent/US8569271B2

## CPC

- A61K 31/635: having a heterocyclic ring, e.g. sulfadiazine
- A61K 31/135: having aromatic rings {, e.g. ketamine, nortriptyline (methadone A61K31/137)}
- A61K 31/137: Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine {or methadone}
- A61K 31/415: 1,2-Diazoles
- A61K 45/06: Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A61P 19/02: for joint disorders, e.g. arthritis, arthrosis
- A61P 19/08: for bone diseases, e.g. rachitism, Paget's disease
- A61P 21/00: Drugs for disorders of the muscular or neuromuscular system
- A61P 25/00: Drugs for disorders of the nervous system
- A61P 25/02: for peripheral neuropathies
- A61P 25/04: Centrally acting analgesics, e.g. opioids
- A61P 29/00: Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

The present invention relates to pharmaceutical compositions comprising tramadol and celecoxib and their uses as medicaments or analgesics, more particularly for the treatment of severe to moderate pain with an inflammation component.

## Claims

### Claim 1

A pharmaceutical composition comprising a synergistic combination of (rac)-tramadol·HCl and celecoxib or a pharmaceutically acceptable salt or hydrate thereof wherein the molecular ratio of the (rac)-tramadol·HCl to the celecoxib is a molar ratio of from about 1:1 to about 1:5 or from about 1:1 to about 5:1.

### Claim 2 (depends on 1)

A pharmaceutical composition according to claim 1 wherein the celecoxib is in neutral form.

### Claim 3 (depends on 1)

A method for the treatment of pain comprising administering to a subject in need thereof a therapeutically effective amount of at least one pharmaceutical composition according to claim 1.

### Claim 4 (depends on 3)

A method according to claim 3 wherein said pain is selected from acute pain, chronic pain, neuropathic pain, nociceptive pain, mild and severe to moderate pain, hyperalgesia, pain related to central sensitization, allodynia or cancer pain, diabetic neuropathy, diabetic peripheral neuropathy, osteoarthritis, fibromyalgia, rheumatoid arthritis, ankylosing spondylitis, frozen shoulder and sciatica.