Chirally correct retinal cyclodextrin hemiacetals for treating skin disorder

A method of treating, reducing the occurrence of, or improving the symptoms associated with a skin condition comprising administration of a compound of formula (I);

• wherein,
• n=0 to 4, and
• X=a direct bond, —CH2—CH2—O—, or —CH2—CH2—CH2—O—, and
• Z=H, —CH2—CH2—OH, —CH2—CH2—CH2—OH, —SO3H, —SO3M, —PO3H2, —PO3M, or —PO3M2, and
• R=a retinoid, or a carotenoid, and
• M=Na, K, Ca, Mg, Ba, Zn, Mn, Cu, Fe, Co, or Ni, and
• wherein R is selected from the group consisting of;
• wherein Y is point of attachment, and,
• wherein said skin condition is selected from the group consisting of melanogenesis, oxidative damage, inflammation, irritation, loss of cell adhesion, loss of desquamation, extra-cellular matrix breakdown, skin tone loss, loss of keratinization, cellular senescence, skin aging, skin darkening, loss of skin barrier function, loss of skin firmness, rosacea, acne, wrinkles and fine lines, loss of collagen, topical wounds, and combinations thereof.