Method for modulating responsiveness to steroids
AssigneeIndex Pharmaceuticals AB
InventorsAnn-Kristin Spiik, Robert Löfberg, Lisa Charlotta Bandholtz, Oliver Von Stein, Arezou Zargari
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Abstract
A method for enhancing steroid efficacy in a steroid refractory patient afflicted with an inflammatory condition not responding or responding poorly or inadequately to anti-inflammatory treatment comprises administering an oligonucleotide having the sequence formula (SEQ. ID. No. 18) 5′-Xm-TTCGT-Yn-3′ in an effective amount to said patient and wherein X is A, T, C or G, Y is A, T, C or G, m=0-7, n=0-7 and wherein at least one CG dinucleotide is unmethylated.
Claims36
A method for enhancing steroid efficacy in a patient afflicted with an inflammatory condition and currently on and responding adequately to steroid anti-inflammatory treatment, with the inability to be weaned off systemically or topically administered steroid treatment without increasing severity of the inflammatory condition, comprising:
- administering to the patient an oligonucleotide having the sequence 5′-TTCGT-3′ (SEQ ID NO:
- 18) and not more than 100 nucleotides, and wherein at least one CG dinucleotide is unmethylated, wherein the oligonucleotide is administered in an amount effective to improve sensitivity of the patient to the steroid anti-inflammatory treatment and thereby enable the patient to be weaned off of the steroid anti-inflammatory treatment.
Dependencies are inferred from the claim text.