# US 8,569,249 B2 · Method for inhibiting activation of macrophages

> Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt

- Number: US 8,569,249 B2
- Document ID: US8569249B2
- Status: Granted
- Kind: B2
- Application number: 13/161,369
- Filed: 2011-06-15
- Published: 2012-09-20
- Granted: 2013-10-29
- Earliest claimed: 2011-03-14
- Assignees: China Medical University
- Applicants: Wen-Chuan Lin; Jin-Bin Wu; Hui-Ya Ho; Hung-Bo Hsiao
- Inventors: Wen-Chuan Lin; Jin-Bin Wu; Hui-Ya Ho; Hung-Bo Hsiao
- Web page: https://patentgrep.com/patent/US8569249B2

## CPC

- A61K 31/7048: having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin {, digitoxin or digoxin}
- A61P 1/16: for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A61P 19/02: for joint disorders, e.g. arthritis, arthrosis
- A61P 29/00: Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P 35/00: Antineoplastic agents
- A61P 35/04: specific for metastasis
- A61P 43/00: Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

Provided is a method for inhibiting the activation of macrophages in a subject, comprising administrating to the subject an effective amount of an active component selected from the group consisting of a compound of formula (I), a pharmaceutically acceptable salt of the compound, and a pharmaceutically acceptable ester of the compound, and combinations thereof:

## Claims

### Claim 1

A method for inhibiting the activation of macrophages in a subject, comprising administering to the subject in need thereof, an effective amount of an active component selected from the group consisting of a compound of formula (I), a pharmaceutically acceptable salt of the compound, and combinations thereof:
and wherein the dosage of said administering is selected to effectively treat arthritis or hepatitis.

### Claim 2 (depends on 1)

The method as claimed in claim 1, wherein the subject has rheumatoid arthritis.

### Claim 3 (depends on 1)

The method as claimed in claim 1, further comprising: wherein the active component is administered as a pharmaceutical composition.

### Claim 4 (depends on 1)

The method as claimed in claim 1, wherein the active component is administered by oral administration, subcutaneous injection, intravenous injection, or intra-articular injection.

### Claim 5 (depends on 1)

The method as claimed in claim 1, wherein the active component is the compound of formula (I).

### Claim 6

A method for treating inflammation in a subject, comprising administering to the subject in need thereof, an effective amount of an active component selected from the group consisting of a compound of formula (I), a pharmaceutically acceptable salt of the compound, and combinations thereof:

### Claim 7 (depends on 6)

The method as claimed in claim 6, further comprising: wherein the active component is administered as a pharmaceutical composition.

### Claim 8 (depends on 6)

The method as claimed in claim 6, wherein the active component is administered by oral administration, subcutaneous injection, intravenous injection, or intra-articular injection.

### Claim 9 (depends on 6)

The method as claimed in claim 6, wherein the active component is the compound of formula (I).