# US 8,569,247 B2 · Hydrolysate of crocin > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 8,569,247 B2 - Document ID: US8569247B2 - Status: Granted - Kind: B2 - Application number: 12/706,959 - Filed: 2010-02-17 - Published: 2010-08-19 - Granted: 2013-10-29 - Earliest claimed: 2009-02-18 - Assignees: Omnica GmbH - Applicants: Thomas Eidenberger - Inventors: Thomas Eidenberger - Web page: https://patentgrep.com/patent/US8569247B2 ## CPC - A23L 33/105: Plant extracts, their artificial duplicates or their derivatives - A61K 8/602: {Glycosides, e.g. rutin} - A61K 31/7028: Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages - A61K 36/744: Gardenia - A61K 36/88: Liliopsida (monocotyledons) - A61P 1/16: for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics - A61P 3/06: Antihyperlipidemics - A61P 9/00: Drugs for disorders of the cardiovascular system - A61P 9/10: for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis - A61P 15/00: Drugs for genital or sexual disorders (for disorders of sex hormones A61P5/24); Contraceptives - A61P 25/24: Antidepressants - A61P 25/28: for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia - A61P 27/02: Ophthalmic agents - A61P 29/00: Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] - A61P 35/00: Antineoplastic agents - A61Q 19/00: Preparations for care of the skin - A23L: FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF (preservation thereof A23B) - A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D) - A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS - A61Q: SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS ## Abstract The present invention relates to a composition derived from the hydrolysate of plant containing crocin or the derivatives thereof. The composition includes a significant amount of crocetin monoester. The present invention also provides a method to hydrolyze crocin existing in a plant extract, and further relates to the use. ## Claims ### Claim 1 A pharmaceutical or nutraceuctical composition, derived from the extract of a plant containing crocin, comprising a hydrolysate of the extract enriched for the amount of a crocetin monoester of glucosyl and/or gentiobisyl 1% or greater relative to the non-hydrolysate wherein the monoester is derived from crocin during hydrolysis. ### Claim 2 (depends on 1) A pharmaceutical or nutraceuctical composition according to claim 1, further comprising crocin and/or crocetin. ### Claim 3 (depends on 2) A pharmaceutical or nutraceuctical composition according to claim 2, wherein the ratio of crocin: monoester : crocetin is from about (0-25):(1-80):(1-60) by weight. ### Claim 4 (depends on 3) A pharmaceutical or nutraceuctical composition according to claim 3, wherein the ratio of crocin : monoester : crocetin is from about (5-15):(10-60):(5-50) by weight. ### Claim 5 (depends on 4) A pharmaceutical or nutraceuctical composition according to claim 4, wherein the ratio of crocin:monoester:crocetin is from about (10-15):(30-50):(30-40) by weight. ### Claim 6 (depends on 4) A pharmaceutical or nutraceuctical composition according to claim 4, wherein the ratio of crocin:monoester:crocetin is from about 10 to about 40 to about 40 by weight. ### Claim 7 (depends on 1) A pharmaceutical or nutraceuctical composition according to claim 1, wherein the plant containing crocin is gardenia or saffron. ### Claim 8 (depends on 1) A method to prepare a composition according to claim 1, comprising: obtaining a crocin extract low in crocetin monoesters; hydrolyzing the crocin extract to provide a hydrolysate containing crocetin monoesters; preparing a pharmaceutical or nutraceuctical composition from the hydrolysate wherein the crocetin monoesters are derived from crocin hydrolysis wherein the hydrolysate is from the hydrolysis under acidic or basic conditions. ### Claim 9 (depends on 8) A method according to claim 8, wherein the acidic hydrolysis uses HC1, phosphoric acid or oxalic acid. ### Claim 10 (depends on 1) A cosmetic, pharmaceutical, nutraceutical or dietary supplement comprising the composition of claim 1 and a carrier. ### Claim 11 (depends on 1) A method to treat or improve, depression, cancer, gynecological inflammation, atherosclerosis, cardiovascular diseases, Alzheimer's disease, aged-related macular degeneration, hepatitis, cirrhosis, lowering high cholesterol, adjusting bile secretion, or enhancing brain health comprising the step of administering to an individual in need thereof an effective amount of a composition of claim 1 and, optionally, a carrier, whereby depression, cancer, gynecological inflammation, atherosclerosis, cardiovascular diseases, Alzheimer's disease, aged-related macular degeneration, hepatitis, cirrhosis, lowering high cholesterol, adjusting bile secretion, or enhancing brain health is treated, or improved. ### Claim 12 (depends on 1) The pharmaceutical or nutraceuctical composition according to claim 1, wherein the hydrolysate has been isolated and/or purified. ### Claim 13 (depends on 10) The supplement of claim 10, wherein the hydrolysate has been isolated and/or purified. ### Claim 14 (depends on 11) The method of claim 11, wherein the hydrolysate has been isolated and/or purified.