# US 8,569,236 B2 · Resuscitation fluid > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 8,569,236 B2 - Document ID: US8569236B2 - Status: Granted - Kind: B2 - Application number: 13/708,411 - Filed: 2012-12-07 - Published: 2013-04-18 - Granted: 2013-10-29 - Earliest claimed: 2007-12-22 - Applicants: Cuthbert O. Simpkins - Inventors: Cuthbert O. Simpkins - Web page: https://patentgrep.com/patent/US8569236B2 ## CPC - A61K 9/0026: {Blood substitute; Oxygen transporting formulations; Plasma extender} - A61K 9/0019: {Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner (non-active ingredients are additionally classified in A61K47/00)} - A61K 9/107: Emulsions {; Emulsion preconcentrates; Micelles (composition of emulsions A61K47/00)} - A61K 9/50: Microcapsules {having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals (A61K9/2081 takes precedence; particles with a single coating comprising drug A61K9/167)} - A61K 31/4172: Imidazole-alkanecarboxylic acids, e.g. histidine - A61K 31/66: Phosphorus compounds - A61K 38/38: Albumins - A61K 38/385: {Serum albumin} - A61K 45/06: Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca - A61P 7/00: Drugs for disorders of the blood or the extracellular fluid - A61P 7/06: Antianaemics - A61P 7/08: Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock (artificial tears A61P27/04) - A61P 9/00: Drugs for disorders of the cardiovascular system - A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D) - A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS ## Abstract A method for treating conditions related to lack of blood supply with a lipid based resuscitation fluid is disclosed. The resuscitation fluid contains a lipid component and an aqueous carrier. The lipid component forms an emulsion with the aqueous carrier. The resuscitation fluid can be used to increase the blood pressure and to carry oxygen to tissues. The resuscitation fluid can also be used for preserving the biological integrity of donor organs for transplantation. ## Claims ### Claim 1 A resuscitation kit, comprising: a lipid based resuscitation fluid comprising a lipid component and an aqueous carrier, wherein said lipid component forms an emulsion with said aqueous carrier in the form of lipid micelles with a polar outer surface and an inner hydrophobic space, wherein said resuscitation fluid is used to carry oxygen to tissues; and an oxygenation device adapted for oxygenating said resuscitation fluid immediately prior to application. ### Claim 2 (depends on 1) The resuscitation kit of claim 1, wherein said oxygenation device is a container containing an oxygenating gas. ### Claim 3 (depends on 2) The resuscitation kit of claim 2, wherein said oxygenating gas comprises 90-100% (v/v) oxygen. ### Claim 4 (depends on 2) The resuscitation kit of claim 2, wherein said oxygenating gas comprises a mixture of oxygen, hydrogen sulfide and carbon monoxide. ### Claim 5 (depends on 2) The resuscitation kit of claim 2, wherein said oxygenating gas comprises a mixture of oxygen and hydrogen sulfide. ### Claim 6 (depends on 2) The resuscitation kit of claim 2, wherein said oxygenating gas comprises a mixture of oxygen and carbon monoxide. ### Claim 7 (depends on 1) The resuscitation kit of claim 1, wherein said lipid based resuscitation fluid comprises a lipid emulsion comprising 20% (w/v) purified soybean oil, 1.2% (w/v) purified egg phospholipids, and 2.25% (w/v) glycerol anhydrous. ### Claim 8 (depends on 7) The resuscitation kit of claim 7, wherein said lipid based resuscitation fluid further comprises approximately 5% (w/v) albumin. ### Claim 9 (depends on 1) The resuscitation kit of claim 1, wherein said oxygenation device comprises an air pump. ### Claim 10 (depends on 1) The resuscitation kit of claim 1, further comprising an intravenous infusion (IV) set. ### Claim 11 (depends on 1) The resuscitation kit of claim 1, wherein said resuscitation fluid further comprises histidine. ### Claim 12 (depends on 1) The resuscitation kit of claim 1, wherein said resuscitation fluid further comprises histidine at a concentration of between 0.01M to 0.2M. ### Claim 13 (depends on 1) The resuscitation kit of claim 1, wherein said resuscitation fluid further comprises at least one additive selected from the group consisting of oncotic agents, crystallioid agents, buffering agents, carbohydrates, salts, vitamins, antibodies, and surfactants. ### Claim 14 (depends on 1) The resuscitation kit of claim 1, wherein said lipid based resuscitation fluid comprises a lipid emulsion comprising soybean oil and phospholipids. ### Claim 15 (depends on 1) The resuscitation kit of claim 1, wherein said lipid based resuscitation fluid comprises a lipid emulsion comprising purified soybean oil, purified egg phospholipids, and glycerol anhydrous. ### Claim 16 (depends on 1) The resuscitation kit of claim 1, wherein said lipid based resuscitation fluid does not contain perfluorocarbon or hemoglobin. ### Claim 17 A resuscitation kit, comprising: An oxygenated lipid based resuscitation fluid comprising a lipid component and an aqueous carrier, wherein said lipid component forms an emulsion with said aqueous carrier in the form of lipid micelles with a polar outer surface and an inner hydrophobic space, wherein said resuscitation fluid is used to carry oxygen to tissues; and an oxygenation device adapted for re-oxygenating said resuscitation fluid immediately prior to application. ### Claim 18 (depends on 17) The resuscitation kit of claim 17, wherein said lipid based resuscitation fluid does not contain perfluorocarbon or hemoglobin.