Treatment of kidney disorders with VIP fragments
AssigneeVectus Biosystems Pty Limited
InventorKaren Annette Duggan
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Abstract
The invention relates to compositions comprising vasoactive intestinal peptide (VIP) or fragments thereof, and the use of such compositions in the treatment of kidney disease, in particular kidney fibrosis, and other associated conditions.
Claims8
A method of therapeutic treatment of kidney fibrosis in a subject, the method comprising administering to the subject a composition comprising a pharmaceutically effective amount of one or more functional VIP fragments comprising amino acids 4 to 12 of VIP, wherein the one or more functional VIP fragments are selected from VIP(4-12), VIP(4-16), VIP(4-20), and VIP(4-24), optionally in combination with a pharmaceutically acceptable carrier.
A method of reducing the levels of pro-fibrotic mediators, inhibiting or reducing the production of pro-fibrotic mediators, reducing collagen formation, or enhancing collagen degradation in the kidney in a subject having established kidney fibrosis, the method comprising administering to the subject a composition comprising a pharmaceutically effective amount of one or more functional VIP fragments comprising amino acids 4 to 12 of VIP, wherein the one or more functional VIP fragments are selected from VIP(4-12), VIP(4-16), VIP(4-20), and VIP(4-24), optionally in combination with a pharmaceutically acceptable carrier.
Dependencies are inferred from the claim text.