# US 8,569,232 B2 · Therapeutic agent for diabetes

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- Number: US 8,569,232 B2
- Document ID: US8569232B2
- Status: Granted
- Kind: B2
- Application number: 12/740,362
- Filed: 2008-10-17
- Published: 2011-02-24
- Granted: 2013-10-29
- Earliest claimed: 2007-10-31
- Assignees: Kobe University; JCR Pharmaceuticals Co., Ltd.
- Applicants: Yutaka Takahashi; Kazuo Chihara
- Inventors: Yutaka Takahashi; Kazuo Chihara
- Web page: https://patentgrep.com/patent/US8569232B2

## CPC

- C07K 14/52: Cytokines; Lymphokines; Interferons
- A61P 3/10: for hyperglycaemia, e.g. antidiabetics
- A61K 38/00: Medicinal preparations containing peptides (peptides containing beta-lactam rings A61K31/00; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, A61K31/00; ergot alkaloids of the cyclic peptide type A61K31/48; containing macromolecular compounds having statistically distributed amino acid units A61K31/74; medicinal preparations containing antigens or antibodies A61K39/00; medicinal preparations characterised by the non-active ingredients, e.g. peptides as drug carriers, A61K47/00)
- C07K: PEPTIDES (peptides in foodstuffs A23; obtaining protein compositions for foodstuffs, working-up proteins for foodstuffs A23J; preparations for medicinal purposes A61K; peptides containing beta-lactam rings C07D; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, C07D; ergot alkaloids of the cyclic peptide type C07D519/02; macromolecular compounds having statistically distributed amino acid units in their molecules, i.e. when the preparation does not provide for a specific; but for a random sequence of the amino acid units, homopolyamides and block copolyamides derived from amino acids C08G69/00; macromolecular products derived from proteins C08H1/00; preparation of glue or gelatine C09H; single cell proteins, enzymes C12N; genetic engineering processes for obtaining peptides C12N15/00; compositions for measuring or testing processes involving enzymes C12Q; investigation or analysis of biological material G01N33/00)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)

## Abstract

Disclosed are method for treating diabetes, a protein for treatment of diabetes, and pharmaceutical composition comprising the same. The protein is human mature chemerin, which can be used to treat diabetes, in particular type 2 diabetes, inter alia to treat diabetes in a patient who is concurrently administered with insulin.

## Claims

### Claim 1

A method for treatment of diabetes in a patient in need thereof comprising administering to the patient a therapeutically effective amount of human mature chemerin.

### Claim 2 (depends on 1)

The method according to claim 1, wherein the diabetes is type 1 diabetes or type 2 diabetes.

### Claim 3 (depends on 1)

The method according to claim 1, wherein the diabetes is type 2 diabetes.

### Claim 4 (depends on 1)

The method according to claim 1, further comprising concurrently administering insulin.

### Claim 5 (depends on 1)

The method according to claim 1, comprising administering the human mature chemerin in the form of an injection.

### Claim 6 (depends on 5)

The method according to claim 5, wherein the injection is an aqueous preparation comprising the human mature chemerin.

### Claim 7 (depends on 5)

The method according to claim 5, wherein the injection comprises a lyophilizate comprising the human mature chemerin.

### Claim 8 (depends on 1)

The method according to claim 1, wherein the human mature chemerin comprises the amino acid sequence of SEQ ID NO: 5.