US 8,569,058 B2 · Nerve regeneration promoters

Abstract

A nerve regeneration which comprises a compound is represented by formula (I): (wherein all symbols are shown in the description), a salt thereof or a prodrug thereof. The compound of the present invention is suppresses nerve cell death as a substance for accelerating growth and/or differentiation of stem cells (nerve stem cells, embryonic stem cells, bone marrow cells, etc.), a substance for accelerating growth and/or differentiation of nerve precursor cells, a potentiator for neurotrophic factor activity, a neurotrophic factor-like substance or a neurodegenerative suppressor, and accelerates repair and regeneration of nerve tissues by neogenesis, regeneration and/or axon evolution. In addition, the compound of the present invention is useful for preparation from brain tissues, bone marrow and/or embryonic stem cells of cells for transplant (nerve stem cells, nerve precursor cells, nerve cells, etc.) and also accelerates grafting, growth, differentiation and/or function expression of cells for transplant whereupon it is useful for prevention and/or treatment of neurodegenerative diseases.

Claims2

Dependent claims

A method of in vitro culturing astrocytes for inducing differentiation into neurons, comprising the steps of:

preparing astrocytes from a mammal,
in vitro culturing said astrocytes in differentiation medium comprising N2 supplement, and
in vitro culturing said astrocytes in media comprising (2R)-2-propyloctanoic acid or a salt thereof,
wherein said culturing in said media induces the proliferation and differentiation of said astrocytes into neurons.

1 more element

Dependencies are inferred from the claim text.

Facts

Application

10/574,479Filed 1 Oct 2004

Priority

JP P. 2003-3451233 Oct 2003

Published

US 2007/0043114 A122 Feb 2007

Granted

29 Oct 2013

Term ends

Not estimatedThe source records don’t support an estimate.

Classification13 codes

A61K 31/20
Carboxylic acids, e.g. valproic acid: having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
A61K 31/19
Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids: carboxylic acids, e.g. valproic acid
A61K 45/06
Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00: mixtures of active ingredients without…
A61P 9/00
Drugs for disorders of the cardiovascular system

Nerve regeneration promoters

Life of this patent

Nerve regeneration promoters

Life of this patent

Abstract

Claims2