# US 8,569,052 B2 · Oxygen depletion devices and methods for removing oxygen from red blood cells > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 8,569,052 B2 - Document ID: US8569052B2 - Status: Granted - Kind: B2 - Application number: 13/115,532 - Filed: 2011-05-25 - Published: 2012-04-26 - Granted: 2013-10-29 - Earliest claimed: 2009-10-12 - Assignees: New Health Sciences, Inc.; University of Pittsburgh—Of the Commonwealth System of Higher Education - Applicants: William J. Federspiel; Brian J. Frankowski; Tatsuro Yoshida; Paul J. Vernucci - Inventors: William J. Federspiel; Brian J. Frankowski; Tatsuro Yoshida; Paul J. Vernucci - Web page: https://patentgrep.com/patent/US8569052B2 ## CPC - C12N 5/0641: {Erythrocytes} - A01N 1/14: Mechanical aspects of preservation; Apparatus or containers therefor - A61P 7/06: Antianaemics - A61M 1/0272: {Apparatus for treatment of blood or blood constituents prior to or for conservation, e.g. freezing, drying or centrifuging} - A61M 2202/0208: Oxygen - A61M 2202/0429: Red blood cells; Erythrocytes - C12N: MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA (microbiological testing media C12Q1/00) - A01N: PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF (preservation of food or foodstuff A23); BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES (preparations for medical, dental or toiletry purposes which kill or prevent the growth or proliferation of unwanted organisms A61K); PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS - A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS - A61M: DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY (introducing media into or onto the bodies of animals A61D7/00; means for inserting tampons A61F13/26; devices for administering food or medicines orally A61J; containers for collecting, storing or administering blood or medical fluids A61J1/05); DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY (surgery A61B; chemical aspects of surgical articles A61L); DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR {(Electrotherapy, e.g. producing anaesthesia by the use of alternating or intermittent currents A61N1/36021)} ## Abstract An oxygen depletion device. The device has a cartridge; a plurality of hollow fibers extending within the cartridge from an entrance to an exit thereof; an amount of an oxygen scavenger packed within the cartridge and contiguous to and in between the plurality of hollow fibers. The hollow fibers are adapted to receiving and conveying red blood cells. There is another embodiment of an oxygen depletion device and method for removing oxygen from red blood cells. ## Claims ### Claim 1 An oxygen depletion device comprising: a cartridge; a plurality of hollow fibers extending within said cartridge from an entrance to an exit thereof, wherein the hollow fibers are formed of an oxygen-permeable membrane and are adapted to receiving and conveying red blood cells; and an amount of an oxygen scavenger packed within the cartridge and contiguous to and in between the plurality of hollow fibers, wherein said red blood cells are passaged within said hollow fibers. ### Claim 2 (depends on 1) The device of claim 1, wherein said hollow fibers are substantially parallel and longitudinally disposed within the cartridge from said entrance to said exit. ### Claim 3 (depends on 1) The oxygen depletion device of claim 1, wherein said oxygen scavenger is ferrous iron. ### Claim 4 (depends on 1) The oxygen depletion device of claim 1, wherein said plurality of hollow fibers are formed from an oxygen-permeable material selected from the group consisting of polyolefin, polytetrafluoroethylene, polyester, polvvinylidene fluoride (PVDF), and polysulfone. ### Claim 5 (depends on 1) The oxygen depletion device of claim 1, wherein said plurality of hollow fibers are formed from a hydrophobic polymer. ### Claim 6 (depends on 1) The oxygen depletion device of claim 1, wherein said plurality of hollow fibers are formed from an inorganic ceramic. ### Claim 7 (depends on 1) The oxygen depletion device of claim 1, wherein said plurality of hollow fibers are configured as a linear spiral, a longitudinal spiral, or a coil. ### Claim 8 An oxygen depletion device comprising: a receptacle of a solid material having an inlet and an outlet adapted to receiving and expelling a flushing gas; a plurality of hollow fibers extending within the receptacle from an entrance to an exit thereof; wherein the hollow fibers are adapted to receiving and conveying red blood cells, wherein said red blood cells are passaged within said hollow fibers. ### Claim 9 (depends on 8) The device of claim 8, wherein the hollow fibers are substantially parallel and longitudinally disposed within the cartridge from said entrance to said exit. ### Claim 10 (depends on 8) The device of claim 8, further including a source of flushing gas in communication with said inlet of said receptacle. ### Claim 11 A method for removing oxygen from red blood cells comprising: passing red blood cells through an oxygen depletion device, wherein the device comprises: a cartridge; a plurality of hollow fibers extending within said cartridge from an entrance to an exit thereof, wherein said plurality of hollow fibers are adapted to receiving and conveying red blood cells; and an amount of an oxygen scavenger packed within said cartridge and contiguous to and in between said plurality of hollow fibers, wherein said red blood cells are passaged within said hollow fibers. ### Claim 12 (depends on 11) The method of claim 11, wherein said oxygen scavenger is ferrous iron. ### Claim 13 (depends on 11) The method of claim 11, wherein said plurality of hollow fibers are formed from an oxygen-permeable material selected from the group consisting of polyolefin, polytetrafluoroethylene, polyester, polvvinylidene fluoride (PVDF), and polysulfone. ### Claim 14 (depends on 11) The method of claim 11, wherein said plurality of hollow fibers are formed from a hydrophobic polymer. ### Claim 15 (depends on 11) The method of claim 11, wherein said plurality of hollow fibers are formed from an inorganic ceramic. ### Claim 16 (depends on 11) The method of claim 11, wherein said plurality of hollow fibers are configured as a linear spiral, a longitudinal spiral, or a coil. ### Claim 17 A method for removing oxygen from red blood cells comprising: passing the red blood cells through an oxygen depletion device, wherein the device comprises: a receptacle of a solid material having an inlet and an outlet adapted to receiving and expelling a flushing gas; a plurality of hollow fibers extending within the receptacle from an entrance to an exit thereof, wherein the hollow fibers are adapted to receiving and conveying red blood cells, wherein said red blood cells are passaged within said hollow fibers.