# US 8,569,044 B2 · Method and apparatus for in vivo collection of circulating biological components

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- Number: US 8,569,044 B2
- Document ID: US8569044B2
- Status: Granted
- Kind: B2
- Application number: 13/205,539
- Filed: 2011-08-08
- Published: 2012-02-09
- Granted: 2013-10-29
- Earliest claimed: 2003-12-22
- Assignees: John Wayne Cancer Institute
- Applicants: David Hoon; Bret Taback; Samuel Shaolian
- Inventors: David Hoon; Bret Taback; Samuel Shaolian
- Web page: https://patentgrep.com/patent/US8569044B2

## CPC

- A61B 5/1459: invasive, e.g. introduced into the body by a catheter
- A61B 5/14503: {invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors (A61B5/1459, A61B5/1464, A61B5/1473, A61B5/1482, A61B5/14865 take precedence)}
- A61B 5/6865: {Access ports}
- B82Y 5/00: Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
- B82Y 10/00: Nanotechnology for information processing, storage or transmission, e.g. quantum computing or single electron logic
- B82Y 30/00: Nanotechnology for materials or surface science, e.g. nanocomposites
- A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D)
- B82Y: SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES

## Abstract

The invention relates generally to in vivo collection of circulating molecules, tumor cells and other biological markers using a collecting probe. The probe is configured for placement within a living organism for an extended period of time to provide sufficient yield of biological marker for analysis. In some embodiments of the invention, active attraction of biological markers are provided. A partial or complete analytic/detection assembly may also be integrated with the probe.

## Claims

### Claim 1

A method for detecting disease, comprising the steps of:
introducing a binding agent into a body;
attracting at least a portion of the binding agent to a binding agent attraction device positioned within the body; and
assessing the binding agent attracted to the attraction device.

### Claim 2 (depends on 1)

The method of claim 1, wherein the introducing step is performed by injecting the binding agent into the bloodstream.

### Claim 3 (depends on 1)

The method of claim 1, wherein the introducing step is performed by eluting the binding agent from an implant within the body.

### Claim 4 (depends on 1)

The method of claim 1, wherein the disease is cancer.

### Claim 5 (depends on 1)

The method of claim 1, wherein the disease is an infection.

### Claim 6 (depends on 5)

The method of claim 5, wherein the disease is a bacterial infection.

### Claim 7 (depends on 5)

The method of claim 5, wherein the disease is a viral infection.

### Claim 8 (depends on 5)

The method of claim 5, wherein the disease is a fungal infection.