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US 8,569,013 B2Granted
Penicillin-G acylases
AssigneeCodexis, Inc.
InventorsBehnaz Behrouzian, Anke Krebber, Emily Mundorff
Life of this patent
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Abstract
The present disclosure relates to engineered penicillin G acylase (PGA) enzymes having improved properties, polynucleotides encoding such enzymes, compositions including the enzymes, and methods of using the enzymes.
Claims14
An engineered penicillin G acylase (PGA), wherein the PGA comprises an amino acid sequence having at least 95% identity to SEQ ID NO:
- 4 and at least one of the following amino acid substitutions relative to the reference sequence of SEQ ID NO:32:
- residue corresponding to X28 is valine;
- residue corresponding to X74 is glycine;
- and/or
- residue corresponding to X547 is glutamine.
2 more elements
Dependencies are inferred from the claim text.