Methods of diagnosing, preventing and treating cancer metastasis
AssigneeWhitehead Institute for Biomedical Research
InventorsSendurai Mani, Jing Yang, Robert A. Weinberg
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Abstract
The invention relates to methods and compositions for inhibiting metastasis, such as by inhibiting FOXC2 expression or activity. The invention further relates to methods of prognosticating, diagnosing, and assisting in the diagnosis of metastasis in an individual, or of determining the metastatic potential of a tumor. The invention further relates to methods of identifying agents which inhibit metastasis.
Claims11
An in vitro method of determining if an agent is a potential agent for the treatment of tumor metastasis, the method comprising determining if the agent decreases the expression or activity of FOXC2 in a cell, wherein an agent that decreases the expression or activity of FOXC2 is a potential target for the treatment of tumor metastasis, and wherein the method further comprises administering the agent identified as a potential target for the treatment of tumor metastasis to an animal having a tumor, and determining if the tumor metastasizes in the animal.
Dependencies are inferred from the claim text.