Method for prenatal diagnosis
AssigneeDkfz Deutsches Krebsforschungszentrum Stiftung Des Offentlichen Rechts
InventorsPeter Altevogt, Sascha Keller
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Abstract
The invention discloses a method of prenatal diagnosis comprising the step of isolating exosomes from an isolated fluid, wherein the exosomes are identified by biomarker detection. Furthermore, the invention discloses the isolation of exosomes from an isolated fluid and the use of a biomarker, particularly CD24 to isolate exosomes from an isolated fluid.
Claims10
A method for detecting the presence of exosomes in an isolated fluid comprising identifying the exosomes in the isolated fluid by detecting the presence of CD24-marker on the exosomes.
A method for prenatal diagnosis to detect congenital anomalies of a fetus comprising the steps of:
- (a) isolating exosomes from an isolated fluid sample, and
- (b) detecting pathological fetal conditions from the exosomes isolated in the fluid sample;
- wherein (i) the exosomes are identified by biomarker detection, (ii) the biomarker is CD24, (iii) the isolated fluid sample containing the exosomes is derived from or originated from the fetus, and (iv) the CD24-positive exosomes carry fetal genetic information which provides prenatal diagnosis of congenital anomalies in the fetus.
An isolated exosome, wherein the exosome comprises a CD24-marker.
Dependencies are inferred from the claim text.