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US 8,568,990 B2Granted
Methods for identifying compounds that modulate sensory signaling through the taste cell specific G-protein coupled receptor GPCR-B4
AssigneeThe Regents of the University of California
InventorsCharles S. Zuker, Jon Elliot Adler, Juergen Lindemeier
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Abstract
The invention provides isolated nucleic acid and amino acid sequences of sensory cell specific G-protein coupled receptors, antibodies to such receptors, methods of detecting such nucleic acids and receptors, and methods of screening for modulators of sensory cell specific G-protein coupled receptors.
Claims12
A method for identifying a compound that modulates sensory signaling in sensory cells, the method comprising the steps of:
- (i) contacting the compound with a polypeptide comprising an extracellular domain of a sensory transduction G-protein coupled receptor, the extracellular domain comprising greater than about 90% amino acid sequence identity to the extracellular domain of SEQ ID NO:1 or SEQ ID NO:2;
- and
- (ii) determining the functional effect of the compound upon the extracellular domain.
Dependencies are inferred from the claim text.