Peptides and methods for the detection of Lyme disease antibodies
AssigneeAbaxis, Inc.
InventorsRajesh K. Mehra, Kenneth P. Aron, Dennis M. Bleile
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Abstract
The invention provides compositions (e.g., peptide compositions) useful for the detection of antibodies that bind to Borrelia antigens. The peptide compositions comprise polypeptide sequences comprising variants in the IR6 domain of the Borrelia VlsE protein. The invention also provides devices, methods, and kits comprising such peptide compositions and useful for the detection of antibodies that bind to Borrelia antigens and the diagnosis of Lyme disease.
Claims26
A mixture of isolated peptides comprising two or more isolated peptides, wherein at least one of said isolated peptides comprises the sequence of SEQ ID NO:
- 16, SEQ ID NO:
- 18, SEQ ID NO:
- 36, SEQ ID NO:
- 47, SEQ ID NO:
- 49, SEQ ID NO:
- 51, SEQ ID NO:
- 52, SEQ ID NO:
- 57, SEQ ID NO:
- 66, or SEQ ID NO:
- 70.
A mixture of isolated peptides comprising all possible peptides defined by SEQ ID NO:1, M-K-X3-X4-D-X6-I-A-A-X10-X11-V-L-X14-G-M-A-K -X19-G-X21-F-A-X24-X25 (SEQ ID NO:1)
- wherein X3 is an amino acid selected from the group consisting of R and Q, X4 is an amino acid selected from the group consisting of N and D, X6 is an amino acid selected from the group consisting of N and E, X10 is an amino acid selected from the group consisting of V, F and L, X11 is an amino acid selected from the group consisting of I and M, X14 is an amino acid selected from the group consisting of K, Q and H, X19 is an amino acid selected from the group consisting of N, Q and E, X21 is an amino acid selected from the group consisting of E and Q, X24 is an amino acid selected from the group consisting of I, V, Y and W, and X25 is an amino acid selected from the group consisting of K and R.
Dependencies are inferred from the claim text.