Use of CFH or ApoH as a biochemical diagnostic marker for complete remission in acute myeloid leukemia
AssigneeIndustry Foundation of Chonnam National University
InventorSeung Won Lee
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Abstract
The present invention relates to a diagnostic method for acute myeloid leukemia, in particular, a method for using CFH or ApoH in patient sera as biochemical diagnostic markers to determine complete remission in acute myeloid leukemia. In accordance with this invention, CFH and ApoH are identified as a novel biochemical marker for understanding the biological mechanism and responsiveness to disease in AML patients after induction chemotherapy, and can be used as a biochemical marker for evaluating the prognosis of disease in patients after induction chemotherapy.
Claims7
A method for determining complete remission or non-remission in a patient with acute myeloid leukemia (AML) after chemotherapy, which comprises measuring the level of CFH (complement factor H) or ApoH (apolipoprotein H) in a biological sample selected from the group consisting of blood, serum and plasma from the AML patient by immunoassay, wherein a level of 500-700 μg/ml of CFH or ApoH indicates that the patient is in a non-remission in AML, wherein a similar level of CFH or ApoH compared to the levels thereof in blood, serum or plasma from a normal human indicates that the patient achieves complete remission in AML, and wherein the similar level of CFH or ApoH to the normal human is between +50 μg/ml and −50 μg/ml of a level of CFH or ApoH in the normal human.
Dependencies are inferred from the claim text.