# US 8,568,802 B2 · Process for producing enriched fractions of tetrahydroxycurcumin and tetrahydrotetrahydroxy-curcumin from the extracts of Curcuma longa

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- Number: US 8,568,802 B2
- Document ID: US8568802B2
- Status: Granted
- Kind: B2
- Application number: 12/083,105
- Filed: 2005-10-13
- Published: 2010-07-01
- Granted: 2013-10-29
- Earliest claimed: 2005-10-13
- Assignees: Laila Impex
- Applicants: Ganga Raju Gokaraju; Rama Raju Gokaraju; Venkata Subbaraju Gottumukkala; Venkateswarlu Somepalli
- Inventors: Ganga Raju Gokaraju; Rama Raju Gokaraju; Venkata Subbaraju Gottumukkala; Venkateswarlu Somepalli
- Web page: https://patentgrep.com/patent/US8568802B2

## CPC

- C07C 45/62: by hydrogenation of carbon-to-carbon double or triple bonds
- A01N 65/00: Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof (containing compounds of determined constitution A01N27/00 - A01N59/00)
- A01N 65/48: Zingiberaceae [Ginger family], e.g. ginger or galangal
- A61K 36/9066: Curcuma, e.g. common turmeric, East Indian arrowroot or mango ginger
- A61P 25/16: Anti-Parkinson drugs
- A61P 25/28: for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A61P 29/00: Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P 35/00: Antineoplastic agents
- A61P 39/06: Free radical scavengers or antioxidants
- A61P 43/00: Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C07C 45/673: {by change of size of the carbon skeleton}
- C07C 45/78: Separation; Purification; Stabilisation; Use of additives
- C07C 45/79: by solid-liquid treatment; by chemisorption
- C07C 45/81: by change in the physical state, e.g. crystallisation
- C07C: ACYCLIC OR CARBOCYCLIC COMPOUNDS
- A01N: PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF (preservation of food or foodstuff A23); BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES (preparations for medical, dental or toiletry purposes which kill or prevent the growth or proliferation of unwanted organisms A61K); PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

A process for producing an enriched fraction of tetrahydoxycurcumin containing, tetrahydroxycurcumin, demethylcurcumin, demethylmonodemethoxycurcumin and bisd.emethoxycurcumin and colorless tetrahydroderivatives thereof. The process consists of demethylation of natural curcumins, obtained, in turn, from the organic solvent extract of turmeric from Curcuma species. The said enriched fraction of tetrahydroxycurcumin is subjected to hydrogenation to get colorless tetrahydrotetrahydroxycurcumin enriched fraction. The enriched fractions of tetrahydroxycurcumin and colorless tetrahydrotetrahydroxycurcumin exhibits potent antioxidative action and reduces inflammation.

## Claims

### Claim 1

A composition comprising tetrahydrotetrahydroxycurcumin in the range of 30-80%; tetrahydrodemethylcurcumin in the range of 4-20%; tetrahydrodemethylmonodemethoxycurcumin in the range of 5-25% and tetrahydrobisdemethoxycurcumin in the range of 0.1-10%.

### Claim 2 (depends on 1)

A pharmaceutical or dietary supplement with anti-oxidative and anti-inflammatory activity comprising a therapeutically effective amount of the composition of claim 1, wherein said pharmaceutical or dietary supplement further comprises one or more pharmaceutically acceptable excipients.

### Claim 3

A composition comprising tetrahydroxycurcumin in the range of 30-80%; demethylcurcumin in the range of 4-20%; demethylmonodemethoxy curcumin in the range of 5-25%; and bisdemethoxycurcumin in the range of 0.1-10%.

### Claim 4 (depends on 3)

A pharmaceutical or dietary supplement with anti-oxidative and anti-inflammatory activity comprising a therapeutically effective amount of the composition of claim 3, wherein said pharmaceutical or dietary supplement further comprises one or more pharmaceutically acceptable excipients.

### Claim 5 (depends on 1)

A method for treating inflammation comprising administering to a mammal in need thereof, a therapeutically effective amount of the composition of claim 1.

### Claim 6 (depends on 5)

The method of claim 5 wherein said mammal is a human.

### Claim 7 (depends on 3)

A method for treating inflammation comprising administering to a mammal in need thereof, a therapeutically effective amount of the composition of claim 3.

### Claim 8 (depends on 7)

The method of claim 7 wherein said mammal is a human.