# US 8,568,797 B2 · Method for enhancing the growth and fullness of hair

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- Number: US 8,568,797 B2
- Document ID: US8568797B2
- Status: Granted
- Kind: B2
- Application number: 13/231,329
- Filed: 2011-09-13
- Published: 2013-03-14
- Granted: 2013-10-29
- Earliest claimed: 2011-09-13
- Assignees: Avon Products, Inc.
- Applicants: Michele C. Duggan; Satish Parimoo; Cheng Hwang
- Inventors: Michele C. Duggan; Satish Parimoo; Cheng Hwang
- Web page: https://patentgrep.com/patent/US8568797B2

## CPC

- A61K 8/49: containing heterocyclic compounds
- A61K 8/342: {Alcohols having more than seven atoms in an unbroken chain}
- A61K 8/9706: Algae
- A61K 8/9739: Bryophyta [mosses]
- A61K 8/9794: Liliopsida [monocotyledons]
- A61K 31/045: Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K 31/426: 1,3-Thiazoles
- A61K 36/185: Magnoliopsida (dicotyledons)
- A61K 38/06: Tripeptides
- A61K 45/06: Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A61P 17/14: for baldness or alopecia
- A61Q 7/00: Preparations for affecting hair growth
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61Q: SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS

## Abstract

New fibroblast growth factor receptor 1 (FGFR1) inhibitors have been identified which are useful for promoting the retention and/or growth of keratin fibers, such as hair of the scalp, hair of the face (moustache, beard, etc.), eyebrows, eyelashes, and the like. The FGFR1 inhibitors may be formulated in effective amounts in a variety of cosmetic and personal care products.

## Claims

### Claim 1

A method for promoting growth of keratin fibers comprising topically applying to an area of skin containing keratin fiber follicles a composition comprising a topically acceptable vehicle and a fibroblast growth factor receptor 1 (FGFR1) inhibiting amount of a botanical extract from Pouzolzia pentandra, for a time sufficient to delay the transition of the keratin fiber follicles from the anagen phase to the catagen phase.

### Claim 2 (depends on 1)

The method according to claim 1, wherein said FGFR1 inhibiting amount is from about 0.0001% to about 10% by weight of said composition.

### Claim 3 (depends on 1)

The method according to claim 1, wherein said composition is applied daily.

### Claim 4 (depends on 1)

The method according to claim 1, wherein said composition further includes an additional hair growth agent selected from the group consisting of 5-alpha-reductase inhibitor, vasodilators, prostaglandin F2 α analogs, microcirculation enhancers, creatine, biotinylated tri-peptide, and combinations thereof.

### Claim 5 (depends on 1)

The method according to claim 1, wherein said composition is in the form of a shampoo, hair conditioner, pomade, hair gel, hydroalcoholic tonic, or mousse.

### Claim 6 (depends on 3)

The method according to claim 3, wherein the composition is applied to the hair for at least two weeks.

### Claim 7 (depends on 6)

The method according to claim 6, wherein said FGFR1 inhibiting amount is from about 0.001% to about 3% by weight of said composition.