Medicinal compositions containing honey
AssigneeMedihoney Pty Ltd.
InventorAnthony Peter Moloney
Life of this patent
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Abstract
The present invention relates to medicinal compositions containing a honey having non peroxide antibacterial activity and wherein the composition comprises from about 19% to about 80% water by weight. The use of these compositions in the treatment of eye, respiratory and ear conditions is also disclosed.
Claims14
A method of treating a microbial based ophthalmic condition in a subject, the method comprising administering to the subject a therapeutically effective amount of a medicinal composition comprising a filtered honey having non-peroxide antibacterial activity,
- wherein the honey is substantially derived from a Leptospermum species;
- wherein the honey has been filtered to exclude particles with a diameter of greater than about 25 microns;
- wherein the filtered honey does not undergo yeast fermentation normally associated with honey at moisture contents greater than 19% water by weight;
- and
- wherein the composition comprises at least 19% and less than 30% water by weight and has a water activity of about 0.63 to about 0.85;
- and
- wherein the ophthalmic condition is selected from the group consisting of chronic corneal oedema associated with Fuchs dystrophy, post operative bullous keratopathy, neurotrophic keratitis, recurrent corneal erosion syndrome corneal abrasions/recurrent erosions, corneal ulcers, corneal oedema, chronic blepharitis, chronic meibomitis with marginal keratitis, tear deficient dry eye, contact lens dry eye, chronic post surgery dry eye, tear deficiency—non autoimmune (non-Sjogrens NSTD), tear deficiency—autoimmune (Sjogren's syndrome SSTD), meibomian gland disease (MGD), tear deficiency and meibomian gland disease, graft vs host disease, blepharitis, bacterial conjunctivitis, marginal conjunctivitis, keratitis, Fuchs dystrophy, canaliculitis (infection associated with using plugs), contact lens epitheliopathy, mucocele and staphylococcus blepharitis.
A method of treating a microbial infection in a subject, the method comprising administering to the subject a therapeutically effective amount of a medicinal composition comprising a filtered honey having non-peroxide antibacterial activity,
- wherein the honey is substantially derived from a Leptospermum species;
- wherein the honey has been filtered to exclude particles with a diameter of greater than about 25 microns;
- wherein the filtered honey does not undergo yeast fermentation normally associated with honey at moisture contents greater than 19% water by weight;
- and
- wherein the composition comprises at least 19% and less than 30% water by weight and has a water activity of about 0.63 to about 0.85;
- and
- wherein the microbial infection is caused by a microbial species selected from the group consisting of:
- Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniae, Enterobacter cloacae, Acinetobacter baumanni, Pseudomonas aeruginosa, Enterococcus faecalis, and Enterococcus faecium.
A method of treating a microbial based respiratory condition in a subject, the method comprising administering to the subject a therapeutically effective amount of a medicinal composition comprising a filtered honey having non-peroxide antibacterial activity,
- wherein the honey is substantially derived from a Leptospermum species;
- wherein the honey does not comprise particles with a diameter of greater than about 25 microns;
- wherein the filtered honey does not undergo yeast fermentation normally associated with honey at moisture contents greater than 19% water by weight;
- and
- wherein the composition comprises at least 19% and less than 30% water by weight and has a water activity of about 0.63 to about 0.85;
- and
- wherein the respiratory condition is a bacterial based condition selected from the group consisting of a lung or bronchopulmonary infection, an infection associated with cystic fibrosis, tuberculosis or AIDS, pneumonia, acute bacterial bronchitis, common cold, sinusitis, acute rhinitis, atrophic rhinitis, pharyngitis, tonsillitis, laryngitis and a bacterial infection of the nasal cavity.
A method of treating a microbial based ear condition in a subject, the method comprising administering to the subject a therapeutically effective amount of a medicinal composition comprising a filtered honey having non-peroxide antibacterial activity,
- wherein the honey is substantially derived from a Leptospermum species;
- wherein the honey does not comprise particles with a diameter of greater than about 25 microns;
- wherein the filtered honey does not undergo yeast fermentation normally associated with honey at moisture contents greater than 19% water by weight;
- and
- wherein the composition comprises at least 19% and less than 30% water by weight and has a water activity of about 0.63 to about 0.85;
- and
- wherein the ear condition is bacterial based external otitis, acute or chronic otitis media.
Dependencies are inferred from the claim text.