Dried product and a process for manufacturing the product
AssigneeNippon Zoki Pharmaceutical Co., Ltd.
InventorsMasaharu Kurohashi, Yoji Shibayama
Life of this patent
Estimating the term…
Abstract
A dried product of an extract from inflammatory rabbit skin inoculated with vaccinia virus having an inhibitory activity for the production of a kallikrein-like substance is produced by admixing the extract with a saccharide, sugar alcohol or ascorbic acid before reaching dryness, and then drying the admixture to a solid form such as granules. The dried product may be employed to produce a solid preparation for oral administration, such as tablets, having an inhibitory activity for the production of a kallikrein-like substance.
Claims17
A process for the manufacture of a dried product having an inhibitory activity for the production of a kallikrein from a liquid extract from inflammatory rabbit skin inoculated with vaccinia virus comprising admixing said extract with at least one member selected from the group consisting of glucose, mannose, arabinose, xylose, galactose, sorbose, lactose, sucrose, maltose, raffinose, melezitose, pullulan, dextrin, β-cyclodextrin, dextran, mannitol, maltitol, lactitol, palatinit, sorbitol, and ascorbic acid to obtain a mixture, and then drying the mixture to obtain a dried product having an inhibitory activity for the production of a kallikrein, wherein drying of said extract is carried out at a pH of 8.8 to 9.7.
A process for the manufacture of a dried product having an inhibitory activity for the production of a kallikrein, which method comprises the steps of:
- (i) providing a liquid extract from inflammatory rabbit skin inoculated with vaccinia virus,
- (ii) adding thereto and mixing therewith, before the extract reaches dryness, at least one member selected from the group consisting of glucose, mannose, arabinose, xylose, galactose, sorbose, lactose, sucrose, maltose, raffinose, melezitose, pullulan, dextrin, β-cyclodextrin, dextran, mannitol, maltitol, lactitol, palatinit, sorbitol, and ascorbic acid to obtain a mixture, and then
- (iii) drying the mixture to obtain a dried product having an inhibitory activity for the production of a kallikrein, wherein drying of said extract is carried out at a pH of 8.8 to 9.7.
Dependencies are inferred from the claim text.