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US 8,568,788 B2Granted
Nanoparticulated anesthetic composition for topic use
AssigneesBiolab Sanus Farmaceutica Ltda, Universidade Federal do Rio Grande do Sul
InventorsDante Alário Junior, Silvia Stanisçuski Guterres, Adriana Raffin Pohlmann, Lali Rosoni Zancan
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Abstract
The present invention relates to a nanoparticulated anaesthetic composition for topical use in which at least one local anaesthetic agent is encapsulated in polymeric nanoparticles. The present invention also relates to the use of such polymeric nanoparticles comprising at least one local anaesthetic agent in the preparation of an anaesthetic composition for topical application to the skin or mucosa.
Claims4
An anaesthetic composition for topical application to the skin or mucosa, comprising:
- (i) a suspension of polymeric nanocapsules consisting of:
- (a) poly (ε-caprolactone);
- (b) a combination of lidocaine and prilocalne;
- (c) a tensoactive agent selected from the group consisting of sorbitan monostearate, purified phospholipid, polysorbate 80, or mixtures of these materials;
- and
- (d) water;
- (ii) at least one carboxypolymethylene as a viscosity enhancer,
- wherein said polymeric nanocapsules have an average particle diameter between 116 nm and 164 nm.
5 more elements
Dependencies are inferred from the claim text.