# US 8,568,787 B2 · Hydroxyalkylcellulose microparticles

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- Number: US 8,568,787 B2
- Document ID: US8568787B2
- Status: Granted
- Kind: B2
- Application number: 13/510,096
- Filed: 2010-11-24
- Published: 2012-09-13
- Granted: 2013-10-29
- Earliest claimed: 2009-11-24
- Assignees: Nippon Soda Co., Ltd.
- Applicants: Hirofumi Takeuchi; Satoru Abe; Takeshi Shimotori; Gentaro Nemoto
- Inventors: Hirofumi Takeuchi; Satoru Abe; Takeshi Shimotori; Gentaro Nemoto
- Web page: https://patentgrep.com/patent/US8568787B2

## CPC

- C08B 15/02: Oxycellulose; Hydrocellulose; {Cellulosehydrate, e.g. microcrystalline cellulose}
- A61K 9/0056: {Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals}
- A61K 9/1652: {Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin (homeopathic globules A61K9/1623)}
- A61K 9/2054: {Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose}
- C08B 11/08: with hydroxylated hydrocarbon radicals; Esters, ethers, or acetals thereof
- C08J 3/12: Powdering or granulating
- C08L 1/284: {with hydroxylated hydrocarbon radicals}
- C08J 2301/28: Alkyl ethers
- C08L 2205/18: Spheres
- Y10T 428/2982: Particulate matter [e.g., sphere, flake, etc.]
- C08B: POLYSACCHARIDES; DERIVATIVES THEREOF (polysaccharides containing less than six saccharide radicals attached to each other by glycosidic linkages C07H; fermentation or enzyme-using processes C12P19/00; sugar industry C13; production of cellulose D21)
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- C08J: WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H (working, e.g. shaping, of plastics B29)
- C08L: COMPOSITIONS OF MACROMOLECULAR COMPOUNDS (compositions based on polymerisable monomers C08F, C08G; artificial filaments or fibres D01F; textile treating compositions D06)
- Y10T: TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION

## Abstract

Provided is a method of producing hydroxyalkylcellulose microparticles, the method including generating a pulse shock wave, and supplying a hydroxyalkylcellulose aqueous solution to the pulse shock wave generation region, thereby crushing and drying the hydroxyalkylcellulose aqueous solution. According to the production method, hydroxyalkylcellulose microparticles having a volume-average particle size of at least 0.1 μm but less than 15 μm are obtained. By mixing the hydroxyalkylcellulose microparticles with a principal agent and subjecting the resulting mixture to a tablet compression, a solid preparation having excellent tensile strength and disintegration properties can be obtained.

## Claims

### Claim 1

Hydroxyalkylcellulose microparticles, having a volume-average particle size of at least 0.1 μm but less than 15 μm, wherein a 2% aqueous solution of said microparticles has a viscosity at 20° C. that is within a range from 2.0 to 20.0 mPa·s.

### Claim 2 (depends on 1)

The hydroxyalkylcellulose microparticles according to claim 1, wherein the volume-average particle size is at least 0.1 μm but less than 10 μm.

### Claim 3 (depends on 1)

The hydroxyalkylcellulose microparticles according to claim 1, wherein the shape of the hydroxyalkylcellulose microparticles is spherical.

### Claim 4 (depends on 1)

The hydroxyalkylcellulose microparticles according to claim 1, wherein a 2% aqueous solution of the microparticles has a viscosity at 20° C. that is within a range from 2.0 to 10.0 mPa·s.

### Claim 5 (depends on 1)

The hydroxyalkylcellulose microparticles according to claim 1, wherein a hydroxyalkyl group content is within a range from 40 to 80% by weight.

### Claim 6 (depends on 1)

The hydroxyalkylcellulose microparticles according to claim 1, wherein the hydroxyalkylcellulose is a hydroxypropylcellulose.

### Claim 7 (depends on 1)

A solid preparation, comprising the hydroxyalkylcellulose microparticles of claim 1.

### Claim 8 (depends on 7)

The solid preparation according to claim 7, wherein the solid preparation is a tablet.

### Claim 9 (depends on 7)

The solid preparation according to claim 7, wherein an amount of the hydroxyalkylcellulose microparticles is within a range from 1 to 10% by weight of the solid preparation.