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US 8,568,784 B2Granted
Nanoparticles for delivery of active agents
AssigneeMorehouse School of Medicine
InventorsJames W. Lillard, Rajesh Singh, Shailesh Singh
Life of this patent
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Abstract
Milled nanoparticles comprising a biologically active agent, at least one biopolymer and a coating containing at least one coating which is a polymer or ligand are produced using milling and coating techniques which have not previously been used for these applications.
Claims20
A pharmaceutical composition, comprising:
- planetary ball milled nanoparticles comprising:
- a biologically active agent;
- polyethylene glycol;
- and
- at least one biopolymer selected from the group consisting of starch, cellulose, collagen, lactose and alginate,
- wherein the nanoparticles are coated with a coating agent comprising at least one of polycaprolactone and polyethylene glycol and wherein the planetary ball milled nanoparticles are prepared by a method comprising the steps of:
- (a) mixing the at least one biopolymer dissolved in an aqueous solution with the biologically active agent to form a first mixture;
- (b) mixing the first mixture with polyethylene glycol to form a second mixture;
- (c) drying the second mixture;
- (d) producing nanoparticles of the dried second mixture by planetary ball milling;
- and
- (e) coating the planetary ball milled nanoparticles with the coating agent.
9 more elements
A pharmaceutical composition comprising:
- planetary ball milled nanoparticles comprising:
- an anti-cancer agent;
- polyethylene glycol;
- and
- at least one biopolymer selected from the group consisting of starch, cellulose, collagen, lactose and alginate,
- wherein the nanoparticles have a size in the range of 5-30 nm, and wherein the particles are coated with a coating agent comprising polycaprolactone and wherein the planetary ball milled nanoparticles are prepared by a method comprising the steps of:
- (a) mixing the at least one biopolymer dissolved in an aqueous solution with the anti-cancer agent to form a first mixture;
- (b) mixing the first mixture with polyethylene glycol to form a second mixture;
- (c) drying the second mixture;
- (d) producing nanoparticles of the dried second mixture by planetary ball milling;
- and
- (e) coating the planetary ball milled nanoparticles with the coating agent.
9 more elements
A pharmaceutical composition, comprising:
- planetary ball milled particles comprising:
- an anti-cancer agent selected from the group of paclitaxel and cisplatin;
- polyethylene glycol;
- and
- a biopolymer selected from the group consisting of starch, cellulose, collagen, lactose and alginate,
- wherein the particles have a size in the range of 5 nm to 50 μm, and wherein the particles are coated with one or more layers of polycaprolactone and wherein the planetary ball milled particles are prepared by a method comprising the steps of:
- (a) mixing the biopolymer dissolved in an aqueous solution with the anti-cancer agent to form a first mixture;
- (b) mixing the first mixture with polyethylene glycol to form a second mixture;
- (c) drying the second mixture;
- (d) producing particles of the dried second mixture by planetary ball milling;
- and
- (e) coating the planetary ball milled particles with polycaprolactone.
9 more elements
Dependencies are inferred from the claim text.