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US 8,568,782 B2Granted
Gastroresistant pharmaceutical formulations containing rifaximin
AssigneeAlfa Wassermann S.p.A.
InventorsGiuseppe Claudio Viscomi, Ernesto Palazzini, Villiam Zamboni, Maria Rosaria Pantaleo
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Abstract
The object of the invention consists of pharmaceutical formulations containing rifaximin in the shape of microgranules made gastroresistant by an insoluble polymer at pH values between 1.5 and 4.0 and soluble at pH values between 5.0 and 7.5, by their preparation and by their use in the manufacture of medicinal preparations useful in the treatment of inflammatory bowel diseases (IBD) and mainly Crohn's disease.
Claims30
A gastroresistant rifaximin microgranule comprising rifaximin directly coated with a gastroresistant polymeric material formulation,
- wherein said gastroresistant polymeric material formulation comprises a gastroresistant polymer which is insoluble at pH values from about 1.5 to about 4 and is soluble at pH values from about 5.0 to about 7.5,
- wherein the gastroresistant rifaximin microgranule has a diameter of from about 1 micron to about 900 microns,
- wherein said rifaximin is released at a pH higher than 5.0, and
- wherein the gastroresistant polymer is selected from the group consisting of acrylic polymer, methacrylic acid copolymers, methacrylic acid copolymers with an acrylic or methacrylic ester, cellulose acetate phthalate, hydroxypropyl cellulose acetate phthalate, hydroxypropyl methylcellulose phthalate, polyvinyl acetate phthalate, methacrylic acid ethylacrylate copolymer, and mixtures thereof.
1 more element
Dependencies are inferred from the claim text.