Back to results
US 8,568,781 B2Granted
Peptide-carrying nanoparticles
AssigneeMidatech Limited
InventorsThomas Rademacher, Phillip Williams, Christof Bachmann, Africa Garcia Barrientos, Esther de Torres Dominguez, Javier del Campo Menoyo
Life of this patent
Estimating the term…
Abstract
Nanoparticles having a core and a corona of ligands covalently linked to the core, wherein peptides are bound to or associated with the nanoparticles.
Claims95
A nanoparticle comprising:
- (i) a core comprising a metal;
- (ii) a corona comprising a plurality of ligands covalently linked to the core, wherein at least one of said ligands comprises a carbohydrate moiety;
- and
- (iii) at least one peptide or polypeptide non-covalently bound to the corona.
1 more element
A nanoparticle comprising:
- (i) a core comprising a metal;
- (ii) a corona comprising a plurality of ligands covalently linked to the core, which plurality of ligands comprises at least a first ligand and a second ligand, wherein:
- (a) said first ligand comprises 2′-thioethyl-α-D-galactopyranoside and said second ligand comprises 1-amino-17-mercapto-3,6,9,12,15,-pentaoxa-heptadecanol;
- (b) said first ligand comprises 2′-thioethyl-β-D-glucopyranoside or 2′-thioethyl-α-D-glucopyranoside and said second ligand comprises 5′-thiopentanyl-2-deoxy-2-imidazolacetamido-α,β-D-glucopyranoside;
- (c) said first ligand comprises 2′-thioethyl-β-D-glucopyranoside or 2′-thioethyl-α-D-glucopyranoside and said second ligand comprises 1-amino-17-mercapto-3,6,9,12,15,-pentaoxa-heptadecanol;
- or (d) said first ligand comprises 2′-thioethyl-2-acetamido-2-deoxy-β-D-glucopyranoside and said second ligand comprises 1-amino-17-mercapto-3,6,9,12,15,-pentaoxa-heptadecanol,
- and wherein said first and second ligands are covalently linked to the core via their respective sulphur atoms.
4 more elements
Dependencies are inferred from the claim text.