# US 8,568,768 B2 · Sequestered reactive materials > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 8,568,768 B2 - Document ID: US8568768B2 - Status: Granted - Kind: B2 - Application number: 10/554,191 - Filed: 2004-04-23 - Published: 2006-12-14 - Granted: 2013-10-29 - Earliest claimed: 2003-04-23 - Assignees: The University of Akron - Applicants: Darrell H. Reneker; Daniel J. Smith - Inventors: Darrell H. Reneker; Daniel J. Smith - Web page: https://patentgrep.com/patent/US8568768B2 ## CPC - A61K 9/70: Web, sheet or filament bases {; Films; Fibres of the matrix type containing drug (hollow drug-filled fibres A61K9/0092)} - Y10T 442/2525: Coating or impregnation functions biologically [e.g., insect repellent, antiseptic, insecticide, bactericide, etc.] - A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D) - Y10T: TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION ## Abstract A fibrous assembly is provided for performing site-specific chemistry. In general the present invention provides a fibrous assembly comprising a first fiber that sequesters a first reactive component; and a second fiber that sequesters a second reactive component, wherein at least the first or second fiber releases its reactive component when the fiber is in the presence of a releasing agent, and wherein when the at least first or second fiber releases its reactive component, the first and second reactive components react with each other to form a reaction product. Related methods of manufacture and use are also provided. ## Claims ### Claim 1 A fibrous assembly comprising: a first nanofiber that sequesters a first reactive component; and a second nanofiber that sequesters a second reactive component, wherein at least the first and second nanofiber release their reactive components when the nanofibers are in the presence of a releasing agent, and wherein when the at least first and second nanofibers release their reactive components, the first and second reactive components react with each other to form a reaction product. ### Claim 2 (depends on 1) The fibrous assembly of claim 1, wherein at least the first or second nanofiber is polymeric. ### Claim 3 (depends on 1) The fibrous assembly of claim 1, wherein at least the first or second reactive component is a particle, a dissolved molecule, a fibrous skeleton that was created by electrospinning, a uniform coating, a ribbon, a tube, a gas-filled pore, a fluid-filled pore, or bound to an ion-exchange-resin bead. ### Claim 4 (depends on 1) The fibrous assembly of claim 1, wherein the reaction product of the first reactive component and the second reactive component is nitric oxide. ### Claim 5 (depends on 1) The fibrous assembly of claim 1, wherein the first reactive component is a carboxylic acid and the second reactive component is nitrite. ### Claim 6 (depends on 1) The fibrous assembly of claim 1, wherein the first reactive component is a urethane prepolymer and the second reactive component is a diamine or diol. ### Claim 7 (depends on 1) The fibrous assembly of claim 1, wherein at least the first or second reactive component is bound to an ion-exchange-resin bead. ### Claim 8 (depends on 1) The fibrous assembly of claim 1, wherein the releasing agent is a solvent, a signaling substance, radiation, heat, a mechanical force, a charged particle, an electron, a magnetic particle, a magnetic field, forces from a flowing fluid, hydrostatic pressure, mechanical deformation, or a combination thereof. ### Claim 9 (depends on 1) The fibrous assembly of claim 1, wherein the releasing agent is a solvent. ### Claim 10 (depends on 1) The fibrous assembly of claim 1, wherein at least the first or second nanofiber dissolves or swells in the presence of the releasing agent. ### Claim 11 (depends on 3) The fibrous assembly of claim 3, wherein the fluid is a wax, oil, oligomer-containing fluid, low-molecular-weight liquid, or combination thereof. ### Claim 12 (depends on 5) The fibrous assembly of claim 5, wherein the carboxylic acid is ascorbic acid. ### Claim 13 A method for preparing a fibrous assembly comprising the steps: preparing a first nanofiber that sequesters a first reactive component; preparing a second nanofiber that sequesters a second reactive component; and wherein at least the first and second nanofibers release their sequestered reactive components when the nanofibers are exposed to a releasing agent, and wherein when at least the first and second sequestered reactive components are released from its respective nanofiber, the first and second reactive components react with each other to form a reaction product. ### Claim 14 (depends on 13) The method of claim 13, wherein the first nanofiber is prepared by electrospinning a first electrospinnable solution having a first polymer and a first reactive component; and wherein the second nanofiber is prepared by electrospinning a second electrospinnable solution having a second polymer and a second reactive component, wherein the second reactive component is reactable with the first reactive component. ### Claim 15 (depends on 13) The method of claim 13, wherein a reaction product of the first reactive component and the second reactive component is nitric oxide. ### Claim 16 (depends on 13) The method of claim 13, wherein the first reactive component is a carboxylic acid and the second reactive component is nitrite. ### Claim 17 (depends on 13) The method of claim 13, wherein the first reactive component is a urethane prepolymer and the second reactive component is a diamine or diol. ### Claim 18 (depends on 13) The method of claim 13, wherein at least the first or second reactive component is bound to an ion-exchange-resin bead. ### Claim 19 (depends on 13) The method of claim 13, wherein at least the first or second reactive component is a particle, a dissolved molecule, a fibrous skeleton that was created by electrospinning, a uniform coating, a ribbon, a tube, a gas-filled pre, a fluid-filled pore, or bount to an ion-exchange-resin bead. ### Claim 20 (depends on 14) The method of claim 14, wherein electrospinning the first electrospinnable solution results in a first nanofiber that sequesters the first reactive component, and wherein electrospinning the second electrospinnable solution results in a second nanofiber that sequesters the second. ### Claim 21 (depends on 16) The method of claim 16, wherein the carboxylic acid is ascorbic acid. ### Claim 22 (depends on 19) The method of claim 19, wherein the fluid is a wax, oil, oligomer-containing fluid, low-molecular-weight liquid, or combination thereof. ### Claim 23 A fibrous assembly comprising: a first nanofiber that sequesters a first reactive component, wherein the first nanofiber releases its reactive component when the nanofiber is in the presence of a releasing agent and the reactive component and the releasing agent react to produce a reaction product. ### Claim 24 (depends on 23) The fibrous assembly of claim 23, wherein the first nanofiber is polymeric. ### Claim 25 (depends on 23) The fibrous assembly of claim 23, wherein at least the first reactive component is a particle, a dissolved molecule, a fibrous skeleton that was created by electrospinning, a uniform coating, a ribbon, a tube, a gas-filled pore, a fluid-filled pre, or bound to an ion-exchange-resin bead. ### Claim 26 (depends on 23) The fibrous assembly of claim 23, wherein the reaction product of the first reactive component and the releasing agent is nitric oxide. ### Claim 27 (depends on 23) The fibrous assembly of claim 23, wherein the first reactive component is a carboxylic acid or nitrite. ### Claim 28 (depends on 23) The fibrous assembly of claim 23, wherein the first reactive component is a urethane prepolymer, a diamine, or a diol. ### Claim 29 (depends on 23) The fibrous assembly of claim 23, wherein at least the first reactive component is bound to an ion-exchange-resin bead. ### Claim 30 (depends on 23) The fibrous assembly of claim 23, wherein the releasing agent is a solvent, a signaling substance, radiation, heat, a mechanical force, a charged particle, an electron, a magnetic particle, a magnetic field, forces from a flowing fluid, hydrostatic pressure, mechanical deformation, or a combination thereof. ### Claim 31 (depends on 23) The fibrous assembly of claim 23, wherein the releasing agent is a solvent. ### Claim 32 (depends on 23) The fibrous assembly of claim 23, wherein the first nanofiber dissolves or swells in the presence of the releasing agent. ### Claim 33 (depends on 25) The fibrous assembly of claim 25, wherein the fluid is a wax, oil, oligomer-containing fluid, low-molecular-weight liquid, or combination thereof. ### Claim 34 (depends on 27) The fibrous assembly of claim 27, wherein the carboxylic acid is ascorbic acid.