# US 8,568,765 B2 · Poly (diol co-citrate) hydroxyapatite composite for tissue engineering and orthapaedic fixation devices

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- Number: US 8,568,765 B2
- Document ID: US8568765B2
- Status: Granted
- Kind: B2
- Application number: 13/309,014
- Filed: 2011-12-01
- Published: 2012-09-06
- Granted: 2013-10-29
- Earliest claimed: 2006-02-08
- Assignees: Northwestern University
- Applicants: Guillermo Ameer; Hongjin Qiu; Jian Yang
- Inventors: Guillermo Ameer; Hongjin Qiu; Jian Yang
- Web page: https://patentgrep.com/patent/US8568765B2

## CPC

- A61L 31/127: {containing fillers of phosphorus-containing inorganic materials}
- A61L 27/12: Phosphorus-containing materials, e.g. apatite
- A61L 27/18: obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
- A61L 27/425: {of phosphorus containing material, e.g. apatite}
- A61L 27/427: {of other specific inorganic materials not covered by A61L27/422 or A61L27/425}
- A61L 27/46: with phosphorus-containing inorganic fillers
- A61L 27/58: Materials at least partially resorbable by the body
- A61L 31/026: {Ceramic or ceramic-like structures, e.g. glasses}
- A61L 31/06: obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds {(A61L31/041 takes precedence)}
- A61L 31/121: {having an inorganic matrix}
- A61L 31/123: {of phosphorus-containing materials, e.g. apatite}
- A61L 31/148: {Materials at least partially resorbable by the body}
- A61L 2430/02: for reconstruction of bones; weight-bearing implants
- A61L: METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES (preservation of bodies or disinfecting characterised by the agents employed A01N; preserving, e.g. sterilising, food or foodstuffs A23; preparations for medical, dental or toiletry purposes A61K)

## Abstract

The present invention is directed to a novel poly (diol citrates)-based bioceramic composite materials created using completely biodegradable and a bioceramic material polymers that may be used in implantable devices. More specifically, the specification describes methods and compositions for making and using bioceramic composites comprised of citric acid copolymers and a bioceramic material.

## Claims

### Claim 1

A composition comprising a composite of:
a) a polyester consisting of one or more linear aliphatic diol monomers and a citric acid monomer;
b) a bioceramic used for implantable tissue devices, wherein said composition comprises said bioceramic in an amount of 55% wt % to 75 wt %.

### Claim 2 (depends on 1)

The composition of claim 1, wherein the linear aliphatic diol monomer comprises between about 2 and about 20 carbons.

### Claim 3 (depends on 1)

The composition of claim 1, wherein the polyester comprises repeating units of the same linear aliphatic diol monomer.

### Claim 4 (depends on 3)

The composition of claim 3, wherein the linear aliphatic diol is 1,8-octanediol.

### Claim 5 (depends on 4)

The composition of claim 4, wherein the polyester is poly 1,8-octanediol co-citric acid.

### Claim 6 (depends on 3)

The composition of claim 3, wherein the polyester is poly 1,10 decanediol co-citric acid.

### Claim 7 (depends on 1)

The composition of claim 1, wherein the polyester comprises repeating units of different linear aliphatic diol monomers.

### Claim 8 (depends on 1)

The composition of claim 1, wherein said bioceramic is selected from the group consisting of calcium phosphate bioceramics, aluminabased bioceramics; zirconia-based bioceramics; silica-based bioceramics, and pyrolytic carbon-based bioceramics.

### Claim 9 (depends on 8)

The composition of claim 8, wherein said bioceramic is a calcium phosphate bioceramic.

### Claim 10 (depends on 9)

The composition of claim 9, wherein said bioceramic is hydroxyapatite (HA).

### Claim 11 (depends on 10)

The composition of claim 10, wherein said HA is present in an amount of at least 60 wt %.

### Claim 12 (depends on 10)

The composition of claim 10, wherein said HA is present in an amount of at least 65 wt %.

### Claim 13 (depends on 5)

The composition of claim 5, wherein said composite has a bending strength of from about 33.9 to about 41.4 MPa.

### Claim 14 (depends on 5)

The composition of claim 5, wherein said composite has a compression strength of from about 32 to about 75 MPa.

### Claim 15 (depends on 5)

The composition of claim 5, wherein said composite has a tensile strength of from about 6 to about 10 MPa.

### Claim 16 (depends on 5)

The composition of claim 5, wherein said composite has a shear strength of from about 23 to about 28 MPa.

### Claim 17 (depends on 5)

The composition of claim 5, wherein said composite has a bending modulus of from about 0.275 to about 0.502 GPa.

### Claim 18 (depends on 1)

An implantable device comprising the composition of claim 1.

### Claim 19 (depends on 1)

The composition of claim 1, wherein the bioceramic comprises particles.

### Claim 20 (depends on 19)

The composition of claim 19, wherein the particles have a size from a nanometer to a micron.