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US 8,568,764 B2Granted
Methods of forming coating layers for medical devices utilizing flash vaporization
AssigneeAdvanced Cardiovascular Systems, Inc.
InventorsFlorian N. Ludwig, Syed F. A. Hossainy, Srinivasan Sridharan, Carol Lee
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Abstract
Methods are disclosed for controlling the morphology and the release-rate of active agent from coating layers for medical devices comprising a polymer matrix and one or more active agents. The methods comprise fixing the morphology or phase distribution of the active agent prior to removing solvent from the coating composition. The coating layers can be used for controlled the delivery of an active agent or a combination of active agents.
Claims31
A method comprising:
- preparing a coating composition comprising one or more polymers, one or more active agents, and one or more solvents;
- and
- applying the coating composition onto a medical device with a surface, wherein the medical device surface is at a temperature of 150° C. or greater, whereby the solvent or solvents are flash vaporized to form a coating layer.
Dependencies are inferred from the claim text.