Compositions and coatings for delivery of therapeutic agents
AssigneeUniversity of Tennessee Research Foundation
InventorsOmran R. Abul-Khoudoud, Catherine Cagiannos, Waldemar G. DeRijk, Timothy C. Fabian, Lisa Kyle Jennings
Life of this patent
Estimating the term…
Abstract
Water-soluble polymeric adhesive compositions and their use as delivery vehicles for carrying therapeutic agents on implantable devices, such as vascular grafts, are disclosed. Use of drug-coated vascular grafts is demonstrated for delivery of the therapeutic agents in vivo, thereby inhibiting restenosis or neointimal hyperplasia of the vascular graft and inhibiting infection at the vascular graft site. Methods of forming the adhesive and making the coated vascular grafts are also disclosed.
Claims11
A method of delivering a therapeutic agent to a site, said method comprising:
- providing a delivery vehicle;
- and
- contacting the site with the delivery vehicle wherein the delivery vehicle comprises:
- an implantable polymer body having a surface;
- and
- a layer of a pharmaceutical formulation contacting the surface of the polymer body;
- wherein the pharmaceutical formulation comprises the product resulting from a mixture comprising bisphenyldimethacrylate, N-tolylglycine-glycidylmethacrylate, and a therapeutic agent.
Dependencies are inferred from the claim text.