Hydrophobic polysaccharides with pendent groups having terminal reactive functionalities and medical uses thereof
AssigneeSurModics, Inc.
InventorEmily R. Rolfes Meyering
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Abstract
Hydrophobic α(1→4)glucopyranose polymers useful for the preparation of implantable or injectable medical articles are described. The hydrophobic α(1→4)glucopyranose polymer includes pendent groups having hydrocarbon groups and terminal amine or hydroxyl groups. Biodegradable matrices can be formed from these polymers, and the matrices can be used for the preparation of implantable and injectable medical devices wherein the matrix is capable of degrading in vivo. Matrices including and capable of releasing a bioactive agent in vivo are also described.
Claims22
An implantable or injectable biomedical article, the article comprising a polymeric matrix formed from a composition comprising a hydrophobic poly-α(1→4)glucopyranose polymer comprising:
- a poly-α(1→4)glucopyranose portion and
- a pendent group pendent from the poly-α(1→4)glucopyranose portion, the pendent group comprising a hydrocarbon segment comprising one or more carbon atoms and a hydroxyl or an amine group that is present at a terminus of the pendent group.
A hydrophobic poly-α(1→4)glucopyranose polymer comprising:
- a poly-α(1→4)glucopyranose portion and
- pendent groups that are pendent from the poly-α(1→4)glucopyranose portion, the pendent groups comprising a hydrocarbon segment comprising one or more carbon atoms and a hydroxyl or an amine group that is present at a terminus of the pendent group.
Dependencies are inferred from the claim text.